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• W2010074304 abstract "We investigated the effect of a single subcutaneous dose of zoledronic acid on particle-induced osteolysis and observed excessive regional new bone formation. We utilized the murine calvarial osteolysis model and polyethylene particles in C57BL/J6 mice. Twenty-eight mice were used, seven per group. Specimens were stained with Giemsa dye. The osteoid tissue area was determined. Bone thickness was measured as an indicator of bone growth. Net bone growth was significantly increased in animals with zoledronic acid treatment: 0.02 mm2±0.03 mm2 in animals with particle implantation only (group 2), 0.25 mm2±0.08 mm2 with particle implantation and zoledronic acid treatment directly after surgery (group 3; p=0.0018), and 0.21 mm2±0.11 mm2 with particle implantation and zoledronic acid treatment on the fourth postoperative day (group 4; p=0.0042). The mean bone thickness was 0.2 mm±0.04 mm (range 0.17 mm–0.31 mm) in group 1 (sham controls) and 0.16 mm±0.02 mm (range 0.14 mm–0.19 mm) in group 2, 0.31 mm±0.04 mm (range 0.28 mm–0.39 mm) in group 3, and 0.29 mm±0.02 mm (range 0.28 mm–0.34 mm) in group 4. Student's t-test revealed a statistically significant difference between groups 2 and 3 (p=0.00042), and groups 2 and 4 (p=0.0019). In conclusion, our observational study suggests that zoledronic acid may stimulate bone apposition locally in the process of particle-induced osteolysis." @default.
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• W2010074304 date "2005-06-01" @default.
• W2010074304 modified "2023-09-27" @default.
• W2010074304 title "Stimulation of bone formation by zoledronic acid in particle-induced osteolysis" @default.
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• W2010074304 doi "https://doi.org/10.1016/j.biomaterials.2004.09.026" @default.
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