Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010076112> ?p ?o ?g. }
- W2010076112 endingPage "1424" @default.
- W2010076112 startingPage "1416" @default.
- W2010076112 abstract "Tumor recurrence following surgery is a common and unresolved medical problem of great importance since surgery is the most widely used treatment for solid-mass tumors worldwide. A contributing factor to tumor recurrence is the presence of residual tumor remaining at or near the surgical site following surgery. Goal: The primary objective of this study was to develop and evaluate an image-guided surgery system based on a near-infrared, handheld excitation source and spectrograph in combination with a widefield video imaging system. Methods: This system was designed to detect the fluorescence of near-infrared contrast agents and, in particular, indocyanine green (ICG). The imaging system was evaluated for its optical performance and ability to detect the presence of ICG in tumors in an ectopic murine tumor model as well as in spontaneous tumors arising in canines. Results: In both settings, an intravenous ICG infusion provided tumor contrast. In both the murine models and surgical specimens from canines, ICG preferentially accumulated in tumor tissue compared to surrounding normal tissue. The resulting contrast was sufficient to distinguish neoplasia from normal tissue; in the canine surgical specimens, the contrast was sufficient to permit identification of neoplasia on the marginal surface of the specimen. Conclusion: These results demonstrate a unique concept in image-guided surgery by combining local excitation and spectroscopy with widefield imaging. Significance: The ability to readily detect ICG in canines with spontaneous tumors in a clinical setting exemplifies the potential for further clinical translation; the promising results of detecting neoplasia on the marginal specimen surface underscore the clinical utility." @default.
- W2010076112 created "2016-06-24" @default.
- W2010076112 creator A5014342911 @default.
- W2010076112 creator A5022867429 @default.
- W2010076112 creator A5032670770 @default.
- W2010076112 creator A5062689107 @default.
- W2010076112 creator A5070372356 @default.
- W2010076112 creator A5073036501 @default.
- W2010076112 creator A5079334291 @default.
- W2010076112 date "2015-05-01" @default.
- W2010076112 modified "2023-09-23" @default.
- W2010076112 title "An Integrated Widefield Imaging and Spectroscopy System for Contrast-Enhanced, Image-Guided Resection of Tumors" @default.
- W2010076112 cites W150992930 @default.
- W2010076112 cites W1537947026 @default.
- W2010076112 cites W1601579599 @default.
- W2010076112 cites W1903778810 @default.
- W2010076112 cites W1926941638 @default.
- W2010076112 cites W1964940524 @default.
- W2010076112 cites W1969319564 @default.
- W2010076112 cites W1975206112 @default.
- W2010076112 cites W1978498174 @default.
- W2010076112 cites W1980956174 @default.
- W2010076112 cites W1994645123 @default.
- W2010076112 cites W1998544050 @default.
- W2010076112 cites W2005301907 @default.
- W2010076112 cites W2005903771 @default.
- W2010076112 cites W2006212344 @default.
- W2010076112 cites W2006351650 @default.
- W2010076112 cites W2024516085 @default.
- W2010076112 cites W2032790167 @default.
- W2010076112 cites W2037580750 @default.
- W2010076112 cites W2041916085 @default.
- W2010076112 cites W2042611967 @default.
- W2010076112 cites W2044523676 @default.
- W2010076112 cites W2052182172 @default.
- W2010076112 cites W2059931622 @default.
- W2010076112 cites W2061576920 @default.
- W2010076112 cites W2064349256 @default.
- W2010076112 cites W2088659772 @default.
- W2010076112 cites W2105399422 @default.
- W2010076112 cites W2120592166 @default.
- W2010076112 cites W2122962502 @default.
- W2010076112 cites W2133137172 @default.
- W2010076112 cites W2133174131 @default.
- W2010076112 cites W2139154864 @default.
- W2010076112 cites W2168544783 @default.
- W2010076112 cites W2317932338 @default.
- W2010076112 cites W4234368842 @default.
- W2010076112 doi "https://doi.org/10.1109/tbme.2015.2389626" @default.
- W2010076112 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4435563" @default.
- W2010076112 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25585410" @default.
- W2010076112 hasPublicationYear "2015" @default.
- W2010076112 type Work @default.
- W2010076112 sameAs 2010076112 @default.
- W2010076112 citedByCount "20" @default.
- W2010076112 countsByYear W20100761122015 @default.
- W2010076112 countsByYear W20100761122016 @default.
- W2010076112 countsByYear W20100761122017 @default.
- W2010076112 countsByYear W20100761122018 @default.
- W2010076112 countsByYear W20100761122019 @default.
- W2010076112 countsByYear W20100761122020 @default.
- W2010076112 countsByYear W20100761122022 @default.
- W2010076112 countsByYear W20100761122023 @default.
- W2010076112 crossrefType "journal-article" @default.
- W2010076112 hasAuthorship W2010076112A5014342911 @default.
- W2010076112 hasAuthorship W2010076112A5022867429 @default.
- W2010076112 hasAuthorship W2010076112A5032670770 @default.
- W2010076112 hasAuthorship W2010076112A5062689107 @default.
- W2010076112 hasAuthorship W2010076112A5070372356 @default.
- W2010076112 hasAuthorship W2010076112A5073036501 @default.
- W2010076112 hasAuthorship W2010076112A5079334291 @default.
- W2010076112 hasBestOaLocation W20100761122 @default.
- W2010076112 hasConcept C120665830 @default.
- W2010076112 hasConcept C121332964 @default.
- W2010076112 hasConcept C126838900 @default.
- W2010076112 hasConcept C136229726 @default.
- W2010076112 hasConcept C142724271 @default.
- W2010076112 hasConcept C2776502983 @default.
- W2010076112 hasConcept C2781065829 @default.
- W2010076112 hasConcept C31601959 @default.
- W2010076112 hasConcept C57477423 @default.
- W2010076112 hasConcept C71924100 @default.
- W2010076112 hasConcept C91881484 @default.
- W2010076112 hasConceptScore W2010076112C120665830 @default.
- W2010076112 hasConceptScore W2010076112C121332964 @default.
- W2010076112 hasConceptScore W2010076112C126838900 @default.
- W2010076112 hasConceptScore W2010076112C136229726 @default.
- W2010076112 hasConceptScore W2010076112C142724271 @default.
- W2010076112 hasConceptScore W2010076112C2776502983 @default.
- W2010076112 hasConceptScore W2010076112C2781065829 @default.
- W2010076112 hasConceptScore W2010076112C31601959 @default.
- W2010076112 hasConceptScore W2010076112C57477423 @default.
- W2010076112 hasConceptScore W2010076112C71924100 @default.
- W2010076112 hasConceptScore W2010076112C91881484 @default.
- W2010076112 hasIssue "5" @default.
- W2010076112 hasLocation W20100761121 @default.
- W2010076112 hasLocation W20100761122 @default.
- W2010076112 hasLocation W20100761123 @default.