FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010076164> ?p ?o ?g. }

• W2010076164 endingPage "149" @default.
• W2010076164 startingPage "143" @default.
• W2010076164 abstract "Chemotherapy resistance is an important problem often encountered during the course of breast cancer treatment. In order to design rational and efficacious therapies, the molecular mechanisms used by cells to develop resistance must be investigated. One mechanism employed by cancer cells is to alter cell signaling. This review examines the role of mitogen-activated protein kinases (MAPKs) and their endogenous negative regulators, mitogen-activated protein kinase phosphatases (MKPs), in chemotherapy resistance in breast cancer. MAPK signaling is activated in response to both growth factors and cellular stress. MKPs dephosphorylate MAPKs and are part of the dual-specificity family of phosphatases. MAPKs have been shown to be involved in resistance to tamoxifen, and MKPs have been linked to resistance to treatment with doxorubicin, mechlorethamine, paclitaxel, proteasome inhibitors, and oxidative-stress-induced cell death in breast cancer. The role of MKPs in tamoxifen resistance and the elucidation of the mechanisms involved with resistance to standard chemotherapy agents need to be investigated further. Growing evidence suggests that modulating MKP-1 activity could be a viable option to make breast cancer chemotherapy more effective." @default.
• W2010076164 created "2016-06-24" @default.
• W2010076164 creator A5013485822 @default.
• W2010076164 creator A5059971077 @default.
• W2010076164 date "2010-01-29" @default.
• W2010076164 modified "2023-10-16" @default.
• W2010076164 title "The role of MAP kinases and MAP kinase phosphatase-1 in resistance to breast cancer treatment" @default.
• W2010076164 cites W1861588860 @default.
• W2010076164 cites W1966778168 @default.
• W2010076164 cites W1971803865 @default.
• W2010076164 cites W1986888455 @default.
• W2010076164 cites W1988874434 @default.
• W2010076164 cites W1993353592 @default.
• W2010076164 cites W2006456243 @default.
• W2010076164 cites W2008574867 @default.
• W2010076164 cites W2010209978 @default.
• W2010076164 cites W2018978840 @default.
• W2010076164 cites W2024847198 @default.
• W2010076164 cites W2034269086 @default.
• W2010076164 cites W2035192859 @default.
• W2010076164 cites W2063342763 @default.
• W2010076164 cites W2080392472 @default.
• W2010076164 cites W2081673273 @default.
• W2010076164 cites W2082318061 @default.
• W2010076164 cites W2089595068 @default.
• W2010076164 cites W2091352369 @default.
• W2010076164 cites W2093576033 @default.
• W2010076164 cites W2097006689 @default.
• W2010076164 cites W2097255042 @default.
• W2010076164 cites W2099835333 @default.
• W2010076164 cites W2106605842 @default.
• W2010076164 cites W2107149701 @default.
• W2010076164 cites W2111305451 @default.
• W2010076164 cites W2129352379 @default.
• W2010076164 cites W2132990773 @default.
• W2010076164 cites W2135086805 @default.
• W2010076164 cites W2136693393 @default.
• W2010076164 cites W2137355132 @default.
• W2010076164 cites W2144010082 @default.
• W2010076164 cites W2148216137 @default.
• W2010076164 cites W2157285286 @default.
• W2010076164 cites W2162468536 @default.
• W2010076164 cites W2164484108 @default.
• W2010076164 cites W2170825753 @default.
• W2010076164 doi "https://doi.org/10.1007/s10555-010-9208-5" @default.
• W2010076164 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4063276" @default.
• W2010076164 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20111893" @default.
• W2010076164 hasPublicationYear "2010" @default.
• W2010076164 type Work @default.
• W2010076164 sameAs 2010076164 @default.
• W2010076164 citedByCount "86" @default.
• W2010076164 countsByYear W20100761642012 @default.
• W2010076164 countsByYear W20100761642013 @default.
• W2010076164 countsByYear W20100761642014 @default.
• W2010076164 countsByYear W20100761642015 @default.
• W2010076164 countsByYear W20100761642016 @default.
• W2010076164 countsByYear W20100761642017 @default.
• W2010076164 countsByYear W20100761642018 @default.
• W2010076164 countsByYear W20100761642019 @default.
• W2010076164 countsByYear W20100761642020 @default.
• W2010076164 countsByYear W20100761642021 @default.
• W2010076164 countsByYear W20100761642022 @default.
• W2010076164 countsByYear W20100761642023 @default.
• W2010076164 crossrefType "journal-article" @default.
• W2010076164 hasAuthorship W2010076164A5013485822 @default.
• W2010076164 hasAuthorship W2010076164A5059971077 @default.
• W2010076164 hasBestOaLocation W20100761642 @default.
• W2010076164 hasConcept C11960822 @default.
• W2010076164 hasConcept C121608353 @default.
• W2010076164 hasConcept C126322002 @default.
• W2010076164 hasConcept C132149769 @default.
• W2010076164 hasConcept C178666793 @default.
• W2010076164 hasConcept C184235292 @default.
• W2010076164 hasConcept C2777176818 @default.
• W2010076164 hasConcept C502942594 @default.
• W2010076164 hasConcept C530470458 @default.
• W2010076164 hasConcept C57074206 @default.
• W2010076164 hasConcept C71924100 @default.
• W2010076164 hasConcept C86803240 @default.
• W2010076164 hasConcept C95444343 @default.
• W2010076164 hasConcept C97029542 @default.
• W2010076164 hasConceptScore W2010076164C11960822 @default.
• W2010076164 hasConceptScore W2010076164C121608353 @default.
• W2010076164 hasConceptScore W2010076164C126322002 @default.
• W2010076164 hasConceptScore W2010076164C132149769 @default.
• W2010076164 hasConceptScore W2010076164C178666793 @default.
• W2010076164 hasConceptScore W2010076164C184235292 @default.
• W2010076164 hasConceptScore W2010076164C2777176818 @default.
• W2010076164 hasConceptScore W2010076164C502942594 @default.
• W2010076164 hasConceptScore W2010076164C530470458 @default.
• W2010076164 hasConceptScore W2010076164C57074206 @default.
• W2010076164 hasConceptScore W2010076164C71924100 @default.
• W2010076164 hasConceptScore W2010076164C86803240 @default.
• W2010076164 hasConceptScore W2010076164C95444343 @default.
• W2010076164 hasConceptScore W2010076164C97029542 @default.
• W2010076164 hasIssue "1" @default.
• W2010076164 hasLocation W20100761641 @default.
• W2010076164 hasLocation W20100761642 @default.

• next