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- W2010076942 abstract "Bacterial conjugation is a process by which single-stranded DNA is unidirectionally transferred from donor to recipient bacterium. Conjugative plasmid transfer can accelerate the evolution of bacteria, facilitate various pathogenic processes, and disseminate genes encoding antibiotic resistance. For conjugative plasmid F, proteins involved in plasmid transfer are encoded in the transfer (tra) region. A subset of these proteins assembles to form the F plasmid pore complex, while others are thought to assist in pore complex assembly. One of these accessory proteins, TrbB, is proposed to mediate pore complex formation through disulfide isomerase activity.TrbB is a periplasmic protein encoded by plasmid F. This protein has a predicted thioredoxin-like fold and possesses a C-X-X-C redox active site motif. TrbB is proposed to function in the conjugative process by serving as a disulfide bond isomerase, facilitating proper folding of a subset of F-plasmid-encoded proteins in the periplasm. Previous studies have illustrated that a trbB- F plasmid in Escherichia coli (E.coli)lacking its native disulfide bond isomerase, DsbCE.coli, experiences a 10-fold decrease in mating efficiency, but have not provided direct evidence for disulfide bond isomerase activity. We have demonstrated that TrbB can partially restore transfer of a variant of the distantly related R27 plasmid in which both chromosomal and plasmid genes encoding disulfide bond isomerases are disrupted. Additionally, TrbB displays both disulfide bond isomerase and reductase activities on substrates not involved in conjugation. Unlike canonical members of the disulfide bond isomerase family, however, TrbB lacks both an N-terminal dimerization domain and an alpha-helical linker. Although TrbB diverges structurally from other disulfide bond isomerases, like those isomerases, it relies on a chromosomally encoded protein in E. coli for maintenance of its redox active site." @default.
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- W2010076942 date "2011-02-01" @default.
- W2010076942 modified "2023-09-28" @default.
- W2010076942 title "TrbB from Conjugative Plasmid F: A Representative of a New Class of Dsbd-Dependent Disulfide Isomerases" @default.
- W2010076942 doi "https://doi.org/10.1016/j.bpj.2010.12.1271" @default.
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