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- W2010078328 abstract "Pancreatic cancer remains stubbornly resistant to many key cytotoxic chemotherapeutic agents and novel targeted therapies. The molecular heterogeneity of this cancer may account for therapy failures to date, although our growing arsenal of novel targeted agents could translate into patient survival. The main objectives of this review are to elucidate histological subtypes of pancreatic neoplasms that exhibit the characteristic of a gradual process of differentiation from benign entities to malignant ones. In addition, important genes, molecular abnormalities, and significant pathways of pancreatic cancer are analyzed and a potential clinical interpretation is presented (p16/cdkn2a, k-ras mutations, smad-4/tgf-/stat3, stk-11, braf, brca-2, neurotensin, mucs proteins, palb2, mitochondrial mutations, DNA mismatch repair genes, methylation, microrna expression, epithelial-to-mesenchymal transition, egfr mutations, the pi3k-akt-mtor pathway, the vegf pathway, heat shock proteins, cxcr4, the cox pathway, the src pathway, the hedgehog pathway, pancreatic stellate cells, a progression model, and molecular events in uncommon pancreatic tumors). Finally, future therapeutic directions are elucidated." @default.
- W2010078328 created "2016-06-24" @default.
- W2010078328 creator A5001731243 @default.
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- W2010078328 creator A5048665759 @default.
- W2010078328 creator A5050179686 @default.
- W2010078328 creator A5076032623 @default.
- W2010078328 date "2011-01-01" @default.
- W2010078328 modified "2023-10-09" @default.
- W2010078328 title "Molecular Pathogenesis of Pancreatic Cancer and Clinical Perspectives" @default.
- W2010078328 cites W1511729470 @default.
- W2010078328 cites W1784767961 @default.
- W2010078328 cites W1919174089 @default.
- W2010078328 cites W1964064067 @default.
- W2010078328 cites W1971695831 @default.
- W2010078328 cites W1977075884 @default.
- W2010078328 cites W1977467011 @default.
- W2010078328 cites W1984985057 @default.
- W2010078328 cites W1987058138 @default.
- W2010078328 cites W1994465394 @default.
- W2010078328 cites W2000237223 @default.
- W2010078328 cites W2000378868 @default.
- W2010078328 cites W2001362274 @default.
- W2010078328 cites W2002355858 @default.
- W2010078328 cites W2005015259 @default.
- W2010078328 cites W2005021386 @default.
- W2010078328 cites W2010054443 @default.
- W2010078328 cites W2013102168 @default.
- W2010078328 cites W2015543753 @default.
- W2010078328 cites W2020457650 @default.
- W2010078328 cites W2022195700 @default.
- W2010078328 cites W2022531767 @default.
- W2010078328 cites W2022979958 @default.
- W2010078328 cites W2025610388 @default.
- W2010078328 cites W2026991540 @default.
- W2010078328 cites W2035990123 @default.
- W2010078328 cites W2038167014 @default.
- W2010078328 cites W2041234310 @default.
- W2010078328 cites W2042912493 @default.
- W2010078328 cites W2044210875 @default.
- W2010078328 cites W2046416994 @default.
- W2010078328 cites W2053375200 @default.
- W2010078328 cites W2059490612 @default.
- W2010078328 cites W2061278804 @default.
- W2010078328 cites W2061876263 @default.
- W2010078328 cites W2063204839 @default.
- W2010078328 cites W2066254965 @default.
- W2010078328 cites W2066810823 @default.
- W2010078328 cites W2067495748 @default.
- W2010078328 cites W2068366286 @default.
- W2010078328 cites W2073469295 @default.
- W2010078328 cites W2078558213 @default.
- W2010078328 cites W2082378283 @default.
- W2010078328 cites W2083511611 @default.
- W2010078328 cites W2087389479 @default.
- W2010078328 cites W2087457210 @default.
- W2010078328 cites W2088225476 @default.
- W2010078328 cites W2094882473 @default.
- W2010078328 cites W2098267886 @default.
- W2010078328 cites W2098636563 @default.
- W2010078328 cites W2100751052 @default.
- W2010078328 cites W2106825335 @default.
- W2010078328 cites W2108714743 @default.
- W2010078328 cites W2114787622 @default.
- W2010078328 cites W2124863710 @default.
- W2010078328 cites W2125923072 @default.
- W2010078328 cites W2128519797 @default.
- W2010078328 cites W2132194692 @default.
- W2010078328 cites W2133729896 @default.
- W2010078328 cites W2138155367 @default.
- W2010078328 cites W2139017911 @default.
- W2010078328 cites W2140228520 @default.
- W2010078328 cites W2140416475 @default.
- W2010078328 cites W2140872369 @default.
- W2010078328 cites W2142310248 @default.
- W2010078328 cites W2144140851 @default.
- W2010078328 cites W2149115851 @default.
- W2010078328 cites W2149288191 @default.
- W2010078328 cites W2152301579 @default.
- W2010078328 cites W2155730420 @default.
- W2010078328 cites W2156365755 @default.
- W2010078328 cites W2157747088 @default.
- W2010078328 cites W2158134441 @default.
- W2010078328 cites W2161012382 @default.
- W2010078328 cites W2164642954 @default.
- W2010078328 cites W2166655452 @default.
- W2010078328 cites W2168207107 @default.
- W2010078328 cites W2169265947 @default.
- W2010078328 cites W2169895148 @default.
- W2010078328 cites W2339361819 @default.
- W2010078328 doi "https://doi.org/10.1159/000334449" @default.
- W2010078328 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22116519" @default.
- W2010078328 hasPublicationYear "2011" @default.
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