FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010078392> ?p ?o ?g. }

• W2010078392 abstract "Abstract Background Coccidioidomycosis is usually a self-limited infection in immunocompentent people. In immunocompentent human beings second infections due to Coccidioides are very rare, indicating that recovery from infection results in protective immunity. In experimental animals, immunization with several different proteins or attenuated mutants protects against a virulent challenge. To explore what mechanisms are responsible for protective immunity, we investigated the course of Coccidioides infection in the gp91 phox knock out mouse that has a defect in the oxidative burst that results in chronic granulomatous disease. Results We found that the gp91 phox knock out mice were somewhat more resistant to intraperitoneal infection and equally as resistant to low dose intranasal infection, but slightly more susceptible to high dose intranasal infection compared to control mice. The gp91 phox knock out mice made a more robust inflammatory response to infection than controls, as measured by histology and production of inflammatory cytokines. The gp91 phox knock out mice were as protected by immunization with the recombinant Coccidioides protein Ag2/PRA as the controls were against either intraperitoneal or intranasal infection. Coccidioides immitis arthroconidia and spherules were significantly more resistant to H 2 O 2 treatment in vitro than Aspergillus fumigatus spores. Conclusion These data suggest that oxidative burst may not be required for protective immunity to coccidioidomycois." @default.
• W2010078392 created "2016-06-24" @default.
• W2010078392 creator A5035373924 @default.
• W2010078392 creator A5043793286 @default.
• W2010078392 creator A5052552759 @default.
• W2010078392 creator A5079802450 @default.
• W2010078392 date "2011-04-11" @default.
• W2010078392 modified "2023-09-27" @default.
• W2010078392 title "The role of reactive oxygen intermediates in experimental coccidioidomycois in mice" @default.
• W2010078392 cites W1503082038 @default.
• W2010078392 cites W1531113262 @default.
• W2010078392 cites W1604345579 @default.
• W2010078392 cites W1621851081 @default.
• W2010078392 cites W1779827107 @default.
• W2010078392 cites W1859026824 @default.
• W2010078392 cites W1910505291 @default.
• W2010078392 cites W1942910567 @default.
• W2010078392 cites W1958905182 @default.
• W2010078392 cites W1981408889 @default.
• W2010078392 cites W1997356954 @default.
• W2010078392 cites W2006787162 @default.
• W2010078392 cites W2020266239 @default.
• W2010078392 cites W2033014105 @default.
• W2010078392 cites W2036858990 @default.
• W2010078392 cites W2040096048 @default.
• W2010078392 cites W2052012325 @default.
• W2010078392 cites W2060004156 @default.
• W2010078392 cites W2084509745 @default.
• W2010078392 cites W2084814184 @default.
• W2010078392 cites W2101286528 @default.
• W2010078392 cites W2117048934 @default.
• W2010078392 cites W2130321098 @default.
• W2010078392 cites W2153797406 @default.
• W2010078392 cites W2153910927 @default.
• W2010078392 cites W2155208775 @default.
• W2010078392 cites W2169926397 @default.
• W2010078392 cites W2195029035 @default.
• W2010078392 cites W4235080411 @default.
• W2010078392 cites W4313376465 @default.
• W2010078392 doi "https://doi.org/10.1186/1471-2180-11-71" @default.
• W2010078392 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3088889" @default.
• W2010078392 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21481258" @default.
• W2010078392 hasPublicationYear "2011" @default.
• W2010078392 type Work @default.
• W2010078392 sameAs 2010078392 @default.
• W2010078392 citedByCount "15" @default.
• W2010078392 countsByYear W20100783922012 @default.
• W2010078392 countsByYear W20100783922013 @default.
• W2010078392 countsByYear W20100783922016 @default.
• W2010078392 countsByYear W20100783922017 @default.
• W2010078392 countsByYear W20100783922018 @default.
• W2010078392 countsByYear W20100783922019 @default.
• W2010078392 countsByYear W20100783922022 @default.
• W2010078392 crossrefType "journal-article" @default.
• W2010078392 hasAuthorship W2010078392A5035373924 @default.
• W2010078392 hasAuthorship W2010078392A5043793286 @default.
• W2010078392 hasAuthorship W2010078392A5052552759 @default.
• W2010078392 hasAuthorship W2010078392A5079802450 @default.
• W2010078392 hasBestOaLocation W20100783921 @default.
• W2010078392 hasConcept C104317684 @default.
• W2010078392 hasConcept C203014093 @default.
• W2010078392 hasConcept C2778439347 @default.
• W2010078392 hasConcept C2779341262 @default.
• W2010078392 hasConcept C2779787849 @default.
• W2010078392 hasConcept C2780801004 @default.
• W2010078392 hasConcept C2781030883 @default.
• W2010078392 hasConcept C55493867 @default.
• W2010078392 hasConcept C60987743 @default.
• W2010078392 hasConcept C85663871 @default.
• W2010078392 hasConcept C86803240 @default.
• W2010078392 hasConcept C8891405 @default.
• W2010078392 hasConcept C89423630 @default.
• W2010078392 hasConceptScore W2010078392C104317684 @default.
• W2010078392 hasConceptScore W2010078392C203014093 @default.
• W2010078392 hasConceptScore W2010078392C2778439347 @default.
• W2010078392 hasConceptScore W2010078392C2779341262 @default.
• W2010078392 hasConceptScore W2010078392C2779787849 @default.
• W2010078392 hasConceptScore W2010078392C2780801004 @default.
• W2010078392 hasConceptScore W2010078392C2781030883 @default.
• W2010078392 hasConceptScore W2010078392C55493867 @default.
• W2010078392 hasConceptScore W2010078392C60987743 @default.
• W2010078392 hasConceptScore W2010078392C85663871 @default.
• W2010078392 hasConceptScore W2010078392C86803240 @default.
• W2010078392 hasConceptScore W2010078392C8891405 @default.
• W2010078392 hasConceptScore W2010078392C89423630 @default.
• W2010078392 hasIssue "1" @default.
• W2010078392 hasLocation W20100783921 @default.
• W2010078392 hasLocation W20100783922 @default.
• W2010078392 hasLocation W20100783923 @default.
• W2010078392 hasLocation W20100783924 @default.
• W2010078392 hasLocation W20100783925 @default.
• W2010078392 hasOpenAccess W2010078392 @default.
• W2010078392 hasPrimaryLocation W20100783921 @default.
• W2010078392 hasRelatedWork W1598333916 @default.
• W2010078392 hasRelatedWork W1987604971 @default.
• W2010078392 hasRelatedWork W2010078392 @default.
• W2010078392 hasRelatedWork W2156488471 @default.
• W2010078392 hasRelatedWork W2169341339 @default.
• W2010078392 hasRelatedWork W2318343423 @default.
• W2010078392 hasRelatedWork W2319988967 @default.

• next