Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010078538> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2010078538 endingPage "S567" @default.
- W2010078538 startingPage "S567" @default.
- W2010078538 abstract "γ-Secretase is an important contributing enzyme in Alzheimer's disease and is therefore an important therapeutic target. However, the impact of γ-secretase inhibition is not well studied in acute neuroinflammation induced by systemic infection. In this study the influence of γ-secretase on the expression of some proinflammatory markers was assessed in the acute phase as well as the subsiding phase of neuroinflammation. Cerebral γ-secretase cleavage activity was measured by a fluorometric assay after lipopolysaccharide (LPS) intraperitoneal administration. Time profiles of TNF-α and COX-II expression were then determined to detect the time points relevant to the maximal inflammatory responses and the subsequent recovery phase. γ-Secretase activity coincident with TNF-α protein expression returned to its basal level till 8–12 h after systemic challenge with low dose LPS while COX-II over expression lasted for 48–72 h later. Pharmacological inhibition of γ-secretase with local or systemic administration of DAPT (N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester) was performed to indicate the results on the developmental and sinking phases of inflammatory responses in 6 and 72 h post LPS respectively. Our results demonstrate that both local and systemic modulation of γ-secretase hyper-activity with DAPT increase the duration of TNF-α, COX-II, and NFκB induction. We consistently found mild augmented apoptosis in animals treated with DAPT as determined by measuring cleaved caspase-3 expression and by TUNEL assay 72 h following LPS injection. These results suggest that γ-secretase modulation interferes with certain immune regulatory pathways which may restrict some inflammatory transcription factors such as NFκB." @default.
- W2010078538 created "2016-06-24" @default.
- W2010078538 creator A5007244812 @default.
- W2010078538 creator A5012378779 @default.
- W2010078538 creator A5026048740 @default.
- W2010078538 creator A5028236243 @default.
- W2010078538 creator A5040069088 @default.
- W2010078538 creator A5068688487 @default.
- W2010078538 creator A5004579023 @default.
- W2010078538 date "2004-07-01" @default.
- W2010078538 modified "2023-10-18" @default.
- W2010078538 title "P4-324 Nonsteroidal anti-inflammatory drugs (NSAIDS) lower Aβ42 and change presenilin1 confomation" @default.
- W2010078538 doi "https://doi.org/10.1016/s0197-4580(04)81882-7" @default.
- W2010078538 hasPublicationYear "2004" @default.
- W2010078538 type Work @default.
- W2010078538 sameAs 2010078538 @default.
- W2010078538 citedByCount "0" @default.
- W2010078538 crossrefType "journal-article" @default.
- W2010078538 hasAuthorship W2010078538A5004579023 @default.
- W2010078538 hasAuthorship W2010078538A5007244812 @default.
- W2010078538 hasAuthorship W2010078538A5012378779 @default.
- W2010078538 hasAuthorship W2010078538A5026048740 @default.
- W2010078538 hasAuthorship W2010078538A5028236243 @default.
- W2010078538 hasAuthorship W2010078538A5040069088 @default.
- W2010078538 hasAuthorship W2010078538A5068688487 @default.
- W2010078538 hasConcept C126322002 @default.
- W2010078538 hasConcept C164027704 @default.
- W2010078538 hasConcept C17991360 @default.
- W2010078538 hasConcept C185592680 @default.
- W2010078538 hasConcept C190283241 @default.
- W2010078538 hasConcept C196795494 @default.
- W2010078538 hasConcept C2776914184 @default.
- W2010078538 hasConcept C2778754761 @default.
- W2010078538 hasConcept C2779134260 @default.
- W2010078538 hasConcept C31705614 @default.
- W2010078538 hasConcept C36103677 @default.
- W2010078538 hasConcept C502032728 @default.
- W2010078538 hasConcept C55493867 @default.
- W2010078538 hasConcept C71924100 @default.
- W2010078538 hasConcept C87753298 @default.
- W2010078538 hasConcept C98274493 @default.
- W2010078538 hasConceptScore W2010078538C126322002 @default.
- W2010078538 hasConceptScore W2010078538C164027704 @default.
- W2010078538 hasConceptScore W2010078538C17991360 @default.
- W2010078538 hasConceptScore W2010078538C185592680 @default.
- W2010078538 hasConceptScore W2010078538C190283241 @default.
- W2010078538 hasConceptScore W2010078538C196795494 @default.
- W2010078538 hasConceptScore W2010078538C2776914184 @default.
- W2010078538 hasConceptScore W2010078538C2778754761 @default.
- W2010078538 hasConceptScore W2010078538C2779134260 @default.
- W2010078538 hasConceptScore W2010078538C31705614 @default.
- W2010078538 hasConceptScore W2010078538C36103677 @default.
- W2010078538 hasConceptScore W2010078538C502032728 @default.
- W2010078538 hasConceptScore W2010078538C55493867 @default.
- W2010078538 hasConceptScore W2010078538C71924100 @default.
- W2010078538 hasConceptScore W2010078538C87753298 @default.
- W2010078538 hasConceptScore W2010078538C98274493 @default.
- W2010078538 hasLocation W20100785381 @default.
- W2010078538 hasOpenAccess W2010078538 @default.
- W2010078538 hasPrimaryLocation W20100785381 @default.
- W2010078538 hasRelatedWork W1994284968 @default.
- W2010078538 hasRelatedWork W2042602695 @default.
- W2010078538 hasRelatedWork W2171331691 @default.
- W2010078538 hasRelatedWork W2252641125 @default.
- W2010078538 hasRelatedWork W2367837219 @default.
- W2010078538 hasRelatedWork W2371609395 @default.
- W2010078538 hasRelatedWork W2376835941 @default.
- W2010078538 hasRelatedWork W2394192597 @default.
- W2010078538 hasRelatedWork W3012226398 @default.
- W2010078538 hasRelatedWork W3212699394 @default.
- W2010078538 hasVolume "25" @default.
- W2010078538 isParatext "false" @default.
- W2010078538 isRetracted "false" @default.
- W2010078538 magId "2010078538" @default.
- W2010078538 workType "article" @default.