FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010079680> ?p ?o ?g. }

• W2010079680 endingPage "460" @default.
• W2010079680 startingPage "452" @default.
• W2010079680 abstract "The inbred DBA/2J (D2) mouse strain is a well established model of spontaneously elevated intraocular pressure (IOP), progressive glaucomatous loss of retinal ganglion cells (RGCs), and early damage of RGC axons at the level of optic nerve head. Pattern electroretinogram (PERG) studies have shown that surviving RGCs in mice 6–12-month-old may be dysfunctional. RGC dysfunction seems to be IOP-dependent, since it may be exacerbated by means of acute IOP elevation with head-down body tilt. Here we test the hypothesis that head-up body posture lowers IOP, resulting in improvement of PERG amplitude in aged D2 mice with glaucoma. We show that head-up body tilt induces age-independent IOP lowering whose magnitude increases with the angle of tilt. For a fixed angle (−60°) of head-up tilt, IOP progressively decreases with a time constant of about 5 min and stabilizes at a value lower by about 5–6 mm Hg compared to the baseline. Head-up tilt also results in an improvement of PERG amplitude in older D2 mice with glaucoma but not in younger D2 mice without glaucoma. Improvement of PERG amplitude in aged D2 mice upon head-up-induced IOP lowering is consistent with the idea that RGCs undergo a stage of IOP-dependent, reversible dysfunction before death. The head-up IOP/PERG protocol may represent a non-invasive way to probe the potential for recovery of RGC dysfunction in D2 mice." @default.
• W2010079680 created "2016-06-24" @default.
• W2010079680 creator A5081573579 @default.
• W2010079680 creator A5084191707 @default.
• W2010079680 date "2010-03-01" @default.
• W2010079680 modified "2023-09-23" @default.
• W2010079680 title "Head-up tilt lowers IOP and improves RGC dysfunction in glaucomatous DBA/2J mice" @default.
• W2010079680 cites W1553218248 @default.
• W2010079680 cites W1768004330 @default.
• W2010079680 cites W1889456496 @default.
• W2010079680 cites W1964207930 @default.
• W2010079680 cites W1969950010 @default.
• W2010079680 cites W1970428486 @default.
• W2010079680 cites W1971888660 @default.
• W2010079680 cites W1974856833 @default.
• W2010079680 cites W1977884569 @default.
• W2010079680 cites W1980324629 @default.
• W2010079680 cites W1984401984 @default.
• W2010079680 cites W1984509359 @default.
• W2010079680 cites W1984893475 @default.
• W2010079680 cites W1985155816 @default.
• W2010079680 cites W1987363929 @default.
• W2010079680 cites W1987876121 @default.
• W2010079680 cites W1991585300 @default.
• W2010079680 cites W1992902368 @default.
• W2010079680 cites W1998545339 @default.
• W2010079680 cites W2000078621 @default.
• W2010079680 cites W2000632208 @default.
• W2010079680 cites W2001242039 @default.
• W2010079680 cites W2005127845 @default.
• W2010079680 cites W2009091430 @default.
• W2010079680 cites W2009740514 @default.
• W2010079680 cites W2012101359 @default.
• W2010079680 cites W2012389637 @default.
• W2010079680 cites W2012823651 @default.
• W2010079680 cites W2014878702 @default.
• W2010079680 cites W2016518943 @default.
• W2010079680 cites W2019885109 @default.
• W2010079680 cites W2021751894 @default.
• W2010079680 cites W2022209206 @default.
• W2010079680 cites W2026733101 @default.
• W2010079680 cites W2026895146 @default.
• W2010079680 cites W2028023737 @default.
• W2010079680 cites W2045269704 @default.
• W2010079680 cites W2047510146 @default.
• W2010079680 cites W2049862190 @default.
• W2010079680 cites W2050174076 @default.
• W2010079680 cites W2057976755 @default.
• W2010079680 cites W2059882036 @default.
• W2010079680 cites W2066005749 @default.
• W2010079680 cites W2073392343 @default.
• W2010079680 cites W2073761106 @default.
• W2010079680 cites W2079674370 @default.
• W2010079680 cites W2082641269 @default.
• W2010079680 cites W2087647596 @default.
• W2010079680 cites W2092709998 @default.
• W2010079680 cites W2095325048 @default.
• W2010079680 cites W2111090514 @default.
• W2010079680 cites W2135930638 @default.
• W2010079680 cites W2143472502 @default.
• W2010079680 cites W2147122728 @default.
• W2010079680 cites W2154381096 @default.
• W2010079680 cites W2160358735 @default.
• W2010079680 doi "https://doi.org/10.1016/j.exer.2009.12.005" @default.
• W2010079680 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2824077" @default.
• W2010079680 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20036238" @default.
• W2010079680 hasPublicationYear "2010" @default.
• W2010079680 type Work @default.
• W2010079680 sameAs 2010079680 @default.
• W2010079680 citedByCount "36" @default.
• W2010079680 countsByYear W20100796802012 @default.
• W2010079680 countsByYear W20100796802013 @default.
• W2010079680 countsByYear W20100796802014 @default.
• W2010079680 countsByYear W20100796802015 @default.
• W2010079680 countsByYear W20100796802016 @default.
• W2010079680 countsByYear W20100796802017 @default.
• W2010079680 countsByYear W20100796802018 @default.
• W2010079680 countsByYear W20100796802019 @default.
• W2010079680 countsByYear W20100796802020 @default.
• W2010079680 countsByYear W20100796802022 @default.
• W2010079680 crossrefType "journal-article" @default.
• W2010079680 hasAuthorship W2010079680A5081573579 @default.
• W2010079680 hasAuthorship W2010079680A5084191707 @default.
• W2010079680 hasBestOaLocation W20100796802 @default.
• W2010079680 hasConcept C118487528 @default.
• W2010079680 hasConcept C127413603 @default.
• W2010079680 hasConcept C2776521421 @default.
• W2010079680 hasConcept C2778527774 @default.
• W2010079680 hasConcept C2779113765 @default.
• W2010079680 hasConcept C2779844322 @default.
• W2010079680 hasConcept C2780827179 @default.
• W2010079680 hasConcept C2780837183 @default.
• W2010079680 hasConcept C2781092963 @default.
• W2010079680 hasConcept C71924100 @default.
• W2010079680 hasConcept C78519656 @default.
• W2010079680 hasConceptScore W2010079680C118487528 @default.
• W2010079680 hasConceptScore W2010079680C127413603 @default.
• W2010079680 hasConceptScore W2010079680C2776521421 @default.

• next