FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010080912> ?p ?o ?g. }

• W2010080912 endingPage "706" @default.
• W2010080912 startingPage "693" @default.
• W2010080912 abstract "Probiotics represent a potential strategy to influence the host’s immune system thereby modulating immune response. Lipoteichoic Acid (LTA) is a major immune-stimulating component of Gram-positive cell envelopes. This amphiphilic polymer, anchored in the cytoplasmic membrane by means of its glycolipid component, typically consists of a poly (glycerol-phosphate) chain with d-alanine and/or glycosyl substitutions. LTA is known to stimulate macrophages in vitro, leading to secretion of inflammatory mediators such as Nitric Oxide (NO). This study investigates the structure–activity relationship of purified LTA from three probiotic Bacillus strains (Bacillus cereus CH, Bacillus subtilis CU1 and Bacillus clausii O/C). LTAs were extracted from bacterial cultures and purified. Chemical modification by means of hydrolysis at pH 8.5 was performed to remove d-alanine. The molecular structure of native and modified LTAs was determined by 1H NMR and GC–MS, and their inflammatory potential investigated by measuring NO production by RAW 264.7 macrophages. Structural analysis revealed several differences between the newly characterized LTAs, mainly relating to their d-alanylation rates and poly (glycerol-phosphate) chain length. We observed induction of NO production by LTAs from B. subtilis and B. clausii, whereas weaker NO production was observed with B. cereus. LTA dealanylation abrogated NO production independently of the glycolipid component, suggesting that immunomodulatory potential depends on d-alanine substitutions. d-alanine may control the spatial configuration of LTAs and their recognition by cell receptors. Knowledge of molecular mechanisms behind the immunomodulatory abilities of probiotics is essential to optimize their use." @default.
• W2010080912 created "2016-06-24" @default.
• W2010080912 creator A5006680629 @default.
• W2010080912 creator A5017216624 @default.
• W2010080912 creator A5040561507 @default.
• W2010080912 creator A5049426528 @default.
• W2010080912 creator A5057298142 @default.
• W2010080912 creator A5057736103 @default.
• W2010080912 creator A5072248973 @default.
• W2010080912 creator A5077231158 @default.
• W2010080912 date "2014-08-05" @default.
• W2010080912 modified "2023-10-05" @default.
• W2010080912 title "Characterization of lipoteichoic acid structures from three probiotic Bacillus strains: involvement of d-alanine in their biological activity" @default.
• W2010080912 cites W1487799778 @default.
• W2010080912 cites W1548908208 @default.
• W2010080912 cites W1550872831 @default.
• W2010080912 cites W1560481745 @default.
• W2010080912 cites W1916574382 @default.
• W2010080912 cites W1922734004 @default.
• W2010080912 cites W1931635381 @default.
• W2010080912 cites W1965312946 @default.
• W2010080912 cites W1967647423 @default.
• W2010080912 cites W1968109033 @default.
• W2010080912 cites W1974738011 @default.
• W2010080912 cites W1981639989 @default.
• W2010080912 cites W1985342306 @default.
• W2010080912 cites W1986987260 @default.
• W2010080912 cites W1987664943 @default.
• W2010080912 cites W1988436021 @default.
• W2010080912 cites W1990802251 @default.
• W2010080912 cites W1995204654 @default.
• W2010080912 cites W1996671942 @default.
• W2010080912 cites W1996717460 @default.
• W2010080912 cites W2000756495 @default.
• W2010080912 cites W2002886832 @default.
• W2010080912 cites W2008152503 @default.
• W2010080912 cites W2010845547 @default.
• W2010080912 cites W2024879325 @default.
• W2010080912 cites W2033605140 @default.
• W2010080912 cites W2049940196 @default.
• W2010080912 cites W2054114825 @default.
• W2010080912 cites W2055996871 @default.
• W2010080912 cites W2064233887 @default.
• W2010080912 cites W2067232676 @default.
• W2010080912 cites W2069940309 @default.
• W2010080912 cites W2079605309 @default.
• W2010080912 cites W2081140318 @default.
• W2010080912 cites W2087254271 @default.
• W2010080912 cites W2088230367 @default.
• W2010080912 cites W2092503183 @default.
• W2010080912 cites W2095718564 @default.
• W2010080912 cites W2096133690 @default.
• W2010080912 cites W2098784832 @default.
• W2010080912 cites W2098980327 @default.
• W2010080912 cites W2101834325 @default.
• W2010080912 cites W2106426636 @default.
• W2010080912 cites W2110338827 @default.
• W2010080912 cites W2110768898 @default.
• W2010080912 cites W2114132866 @default.
• W2010080912 cites W2122689098 @default.
• W2010080912 cites W2123009778 @default.
• W2010080912 cites W2125470025 @default.
• W2010080912 cites W2127961362 @default.
• W2010080912 cites W2130534359 @default.
• W2010080912 cites W2133803556 @default.
• W2010080912 cites W2135563180 @default.
• W2010080912 cites W2136589285 @default.
• W2010080912 cites W2140076442 @default.
• W2010080912 cites W2153244925 @default.
• W2010080912 cites W2156116033 @default.
• W2010080912 cites W2162755344 @default.
• W2010080912 cites W2168452238 @default.
• W2010080912 cites W2169640926 @default.
• W2010080912 cites W2171406218 @default.
• W2010080912 cites W2211467290 @default.
• W2010080912 cites W4232096655 @default.
• W2010080912 cites W4244747000 @default.
• W2010080912 doi "https://doi.org/10.1007/s10482-014-0239-8" @default.
• W2010080912 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4158176" @default.
• W2010080912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25090957" @default.
• W2010080912 hasPublicationYear "2014" @default.
• W2010080912 type Work @default.
• W2010080912 sameAs 2010080912 @default.
• W2010080912 citedByCount "20" @default.
• W2010080912 countsByYear W20100809122015 @default.
• W2010080912 countsByYear W20100809122016 @default.
• W2010080912 countsByYear W20100809122017 @default.
• W2010080912 countsByYear W20100809122018 @default.
• W2010080912 countsByYear W20100809122019 @default.
• W2010080912 countsByYear W20100809122020 @default.
• W2010080912 countsByYear W20100809122021 @default.
• W2010080912 countsByYear W20100809122022 @default.
• W2010080912 countsByYear W20100809122023 @default.
• W2010080912 crossrefType "journal-article" @default.
• W2010080912 hasAuthorship W2010080912A5006680629 @default.
• W2010080912 hasAuthorship W2010080912A5017216624 @default.
• W2010080912 hasAuthorship W2010080912A5040561507 @default.
• W2010080912 hasAuthorship W2010080912A5049426528 @default.

• next