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- W2010086912 abstract "This investigation was undertaken to determine if vasodilator agents may enhance the diagnostic utility of perfusion lung imaging (Q) by normalizing regional perfusion abnormalities in bronchospastic patients. The effect of oxygen (02), nitroglycerine (NTG), hydralazine (H), and nifedipine (N) on regional lung perfusion defects was studied in 6 mild to severe asthmatics (ages 31–72 yrs) using sequential Kr-81m imaging which permits repetitive imaging due to very low radiation dose and 13 sec T-1/2. Each patient was studied once weekly for 3 wks. Baseline Q scans were obtained using 10mCi of I.V. Kr-8lm. The best view showing perfusion defects was used for subsequent images. At each visit 30% 02 by ventimask was given for 20 min followed by a repeat Q scan. Subsequently, on separate visits, subjects were given either 1 dose of sublingual (sl) N 20mg or 2 doses (1 hr between) of sl NTC 1/150gr or po H 25mg according to a random-order crossover design. Q scans were obtained 2 min after NTG, 60 min after H, and 30 and 60 min after N. 30% 02 was given again for 20 min, and a final scan was obtained. Scans were reviewed by 2 observers and showed relatively fixed defects in 4 pts improvement in defects in 3 pta with NTG, 1 with N, 1 with H, adn 2 with 02 alone. Additive effects of 02 and N or NTG were seen in 2 pts. These preliminary results suggest that vasodilators and 02 may improve regional perfusion in patients with bronchospastic disease and that this effect may be additive. Thus these medications, given prior to the perfusion scan, may improve its specificity for pulmonary embolism." @default.
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- W2010086912 date "1984-09-01" @default.
- W2010086912 modified "2023-09-27" @default.
- W2010086912 title "LUNG PERFUSION DEFECTS - EFFECT OF VASODILATORS" @default.
- W2010086912 doi "https://doi.org/10.1097/00003072-198409001-00029" @default.
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