FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010088346> ?p ?o ?g. }

• W2010088346 endingPage "771" @default.
• W2010088346 startingPage "766" @default.
• W2010088346 abstract "Background We have shown recently that volatile anesthetics significantly decrease inflammatory cytokine production and dramatically increase survival among rodents challenged with lipopolysaccharide (LPS). Because acetylcholine's interaction with nicotine receptors on tissue macrophages during vagus nerve stimulation has been implicated in the modulation of LPS-stimulated tumor necrosis factor alpha (TNF-α) production, we hypothesized that the mechanism of anesthetic immunoprotection is mediated through the vagus nerve. Methods Male Sprague-Dawley rats underwent bilateral cervical vagotomy (n = 20) or sham operation (n = 6). Twenty-four hours postoperatively, vagotomized rats were randomized into 3 groups: LPS injection (V+LPS, n = 6), LPS injection followed by 60 minutes of isoflurane anesthesia (V+LPS+ISO, n = 7), or saline injection (V+S, n = 7). Sham animals were also given LPS (Sham+LPS). A sublethal dose of LPS (8 mg/kg) was used. Blood samples were collected via cardiac puncture 90 minutes after LPS or saline injection, and plasma was isolated for the measurement of cytokines by enzyme-linked immunosorbent assay. Statistical differences between groups were detected by 1-way analysis of variance. Results Serum TNF-α was reduced significantly and interleukin (IL)-6 was abrogated completely among V+LPS+ISO rats, compared with both V+LPS and Sham+LPS animals (P ≤ .05 for all). In contrast, levels of the anti-inflammatory cytokine IL-10 were similar among all LPS groups. Conclusions Isoflurane anesthesia administered simultaneously with the injection of LPS decreases serum production of TNF-α and IL-6 despite bilateral transection of the vagus nerve. Isoflurane-mediated attenuation of proinflammatory cytokine production occurs via a mechanism other than modulation of vagal output. We have shown recently that volatile anesthetics significantly decrease inflammatory cytokine production and dramatically increase survival among rodents challenged with lipopolysaccharide (LPS). Because acetylcholine's interaction with nicotine receptors on tissue macrophages during vagus nerve stimulation has been implicated in the modulation of LPS-stimulated tumor necrosis factor alpha (TNF-α) production, we hypothesized that the mechanism of anesthetic immunoprotection is mediated through the vagus nerve. Male Sprague-Dawley rats underwent bilateral cervical vagotomy (n = 20) or sham operation (n = 6). Twenty-four hours postoperatively, vagotomized rats were randomized into 3 groups: LPS injection (V+LPS, n = 6), LPS injection followed by 60 minutes of isoflurane anesthesia (V+LPS+ISO, n = 7), or saline injection (V+S, n = 7). Sham animals were also given LPS (Sham+LPS). A sublethal dose of LPS (8 mg/kg) was used. Blood samples were collected via cardiac puncture 90 minutes after LPS or saline injection, and plasma was isolated for the measurement of cytokines by enzyme-linked immunosorbent assay. Statistical differences between groups were detected by 1-way analysis of variance. Serum TNF-α was reduced significantly and interleukin (IL)-6 was abrogated completely among V+LPS+ISO rats, compared with both V+LPS and Sham+LPS animals (P ≤ .05 for all). In contrast, levels of the anti-inflammatory cytokine IL-10 were similar among all LPS groups. Isoflurane anesthesia administered simultaneously with the injection of LPS decreases serum production of TNF-α and IL-6 despite bilateral transection of the vagus nerve. Isoflurane-mediated attenuation of proinflammatory cytokine production occurs via a mechanism other than modulation of vagal output." @default.
• W2010088346 created "2016-06-24" @default.
• W2010088346 creator A5015920018 @default.
• W2010088346 creator A5060839514 @default.
• W2010088346 creator A5062752267 @default.
• W2010088346 creator A5077756823 @default.
• W2010088346 creator A5082127043 @default.
• W2010088346 date "2005-10-01" @default.
• W2010088346 modified "2023-09-27" @default.
• W2010088346 title "Anesthesia-specific protection from endotoxic shock is not mediated through the vagus nerve" @default.
• W2010088346 cites W1973977212 @default.
• W2010088346 cites W1994481989 @default.
• W2010088346 cites W1995122826 @default.
• W2010088346 cites W1995525413 @default.
• W2010088346 cites W2010526898 @default.
• W2010088346 cites W2016471640 @default.
• W2010088346 cites W2060674938 @default.
• W2010088346 cites W2069368135 @default.
• W2010088346 cites W2073295417 @default.
• W2010088346 cites W2076342846 @default.
• W2010088346 cites W2081025398 @default.
• W2010088346 cites W2082854725 @default.
• W2010088346 cites W2098655301 @default.
• W2010088346 cites W2122521963 @default.
• W2010088346 cites W2122912984 @default.
• W2010088346 cites W2124525232 @default.
• W2010088346 cites W2145035856 @default.
• W2010088346 cites W2146217294 @default.
• W2010088346 cites W2146648688 @default.
• W2010088346 cites W2334415884 @default.
• W2010088346 cites W2906953680 @default.
• W2010088346 doi "https://doi.org/10.1016/j.surg.2005.06.057" @default.
• W2010088346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16269307" @default.
• W2010088346 hasPublicationYear "2005" @default.
• W2010088346 type Work @default.
• W2010088346 sameAs 2010088346 @default.
• W2010088346 citedByCount "22" @default.
• W2010088346 countsByYear W20100883462013 @default.
• W2010088346 countsByYear W20100883462014 @default.
• W2010088346 countsByYear W20100883462015 @default.
• W2010088346 countsByYear W20100883462016 @default.
• W2010088346 countsByYear W20100883462018 @default.
• W2010088346 countsByYear W20100883462020 @default.
• W2010088346 countsByYear W20100883462022 @default.
• W2010088346 countsByYear W20100883462023 @default.
• W2010088346 crossrefType "journal-article" @default.
• W2010088346 hasAuthorship W2010088346A5015920018 @default.
• W2010088346 hasAuthorship W2010088346A5060839514 @default.
• W2010088346 hasAuthorship W2010088346A5062752267 @default.
• W2010088346 hasAuthorship W2010088346A5077756823 @default.
• W2010088346 hasAuthorship W2010088346A5082127043 @default.
• W2010088346 hasConcept C126322002 @default.
• W2010088346 hasConcept C134018914 @default.
• W2010088346 hasConcept C164027704 @default.
• W2010088346 hasConcept C17991360 @default.
• W2010088346 hasConcept C24998067 @default.
• W2010088346 hasConcept C2776359302 @default.
• W2010088346 hasConcept C2776914184 @default.
• W2010088346 hasConcept C2777397205 @default.
• W2010088346 hasConcept C2778162923 @default.
• W2010088346 hasConcept C2778690821 @default.
• W2010088346 hasConcept C2778720886 @default.
• W2010088346 hasConcept C2778754761 @default.
• W2010088346 hasConcept C2780087125 @default.
• W2010088346 hasConcept C2781404750 @default.
• W2010088346 hasConcept C42219234 @default.
• W2010088346 hasConcept C71924100 @default.
• W2010088346 hasConcept C98274493 @default.
• W2010088346 hasConceptScore W2010088346C126322002 @default.
• W2010088346 hasConceptScore W2010088346C134018914 @default.
• W2010088346 hasConceptScore W2010088346C164027704 @default.
• W2010088346 hasConceptScore W2010088346C17991360 @default.
• W2010088346 hasConceptScore W2010088346C24998067 @default.
• W2010088346 hasConceptScore W2010088346C2776359302 @default.
• W2010088346 hasConceptScore W2010088346C2776914184 @default.
• W2010088346 hasConceptScore W2010088346C2777397205 @default.
• W2010088346 hasConceptScore W2010088346C2778162923 @default.
• W2010088346 hasConceptScore W2010088346C2778690821 @default.
• W2010088346 hasConceptScore W2010088346C2778720886 @default.
• W2010088346 hasConceptScore W2010088346C2778754761 @default.
• W2010088346 hasConceptScore W2010088346C2780087125 @default.
• W2010088346 hasConceptScore W2010088346C2781404750 @default.
• W2010088346 hasConceptScore W2010088346C42219234 @default.
• W2010088346 hasConceptScore W2010088346C71924100 @default.
• W2010088346 hasConceptScore W2010088346C98274493 @default.
• W2010088346 hasIssue "4" @default.
• W2010088346 hasLocation W20100883461 @default.
• W2010088346 hasLocation W20100883462 @default.
• W2010088346 hasOpenAccess W2010088346 @default.
• W2010088346 hasPrimaryLocation W20100883461 @default.
• W2010088346 hasRelatedWork W1789692432 @default.
• W2010088346 hasRelatedWork W1998227988 @default.
• W2010088346 hasRelatedWork W2010088346 @default.
• W2010088346 hasRelatedWork W2044803153 @default.
• W2010088346 hasRelatedWork W2064416809 @default.
• W2010088346 hasRelatedWork W2081597172 @default.
• W2010088346 hasRelatedWork W2226562228 @default.
• W2010088346 hasRelatedWork W2344529250 @default.

• next