Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010095512> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2010095512 endingPage "2955" @default.
- W2010095512 startingPage "2951" @default.
- W2010095512 abstract "A wide variety of pyrrolizidine alkaloids, such as monocrotaline, and the clinically significant mitomycins and the related FR-900482, FK 973, and FR-66979 exert their cytotoxicity through the formation of DNA−DNA interstrand cross-links and DNA−protein cross-links. These naturally occurring antitumor antibiotics are generally either oxidatively or reductively activated in vivo forming a highly reactive pyrrolic-type intermediate, which is responsible for the ultimate DNA cross-linking reaction. These oxidative and reductive pathways, however, often lead to a variety of undesirable toxic events. With the increasing demand for new and less cytotoxic antitumor agents and the recent success of clinically significant photopheresis technologies, we describe here the semisynthesis and DNA cross-linking of the first photochemically triggered progenitor of dehydromonocrotaline." @default.
- W2010095512 created "2016-06-24" @default.
- W2010095512 creator A5002113213 @default.
- W2010095512 creator A5059724481 @default.
- W2010095512 date "1999-03-19" @default.
- W2010095512 modified "2023-10-18" @default.
- W2010095512 title "DNA Cross-Linking by a Phototriggered Dehydromonocrotaline Progenitor" @default.
- W2010095512 cites W135072596 @default.
- W2010095512 cites W1984489982 @default.
- W2010095512 cites W1986490521 @default.
- W2010095512 cites W2001137664 @default.
- W2010095512 cites W2019057275 @default.
- W2010095512 cites W2020319317 @default.
- W2010095512 cites W2027539721 @default.
- W2010095512 cites W2037010153 @default.
- W2010095512 cites W2063756325 @default.
- W2010095512 cites W2079107697 @default.
- W2010095512 cites W2080607769 @default.
- W2010095512 cites W2086872060 @default.
- W2010095512 cites W2087786864 @default.
- W2010095512 cites W2159497438 @default.
- W2010095512 cites W2414188498 @default.
- W2010095512 cites W4211024586 @default.
- W2010095512 doi "https://doi.org/10.1021/ja983894k" @default.
- W2010095512 hasPublicationYear "1999" @default.
- W2010095512 type Work @default.
- W2010095512 sameAs 2010095512 @default.
- W2010095512 citedByCount "51" @default.
- W2010095512 countsByYear W20100955122012 @default.
- W2010095512 countsByYear W20100955122013 @default.
- W2010095512 countsByYear W20100955122014 @default.
- W2010095512 countsByYear W20100955122015 @default.
- W2010095512 countsByYear W20100955122016 @default.
- W2010095512 countsByYear W20100955122017 @default.
- W2010095512 countsByYear W20100955122018 @default.
- W2010095512 countsByYear W20100955122019 @default.
- W2010095512 countsByYear W20100955122020 @default.
- W2010095512 countsByYear W20100955122022 @default.
- W2010095512 crossrefType "journal-article" @default.
- W2010095512 hasAuthorship W2010095512A5002113213 @default.
- W2010095512 hasAuthorship W2010095512A5059724481 @default.
- W2010095512 hasConcept C109316439 @default.
- W2010095512 hasConcept C143425029 @default.
- W2010095512 hasConcept C162776295 @default.
- W2010095512 hasConcept C185592680 @default.
- W2010095512 hasConcept C202751555 @default.
- W2010095512 hasConcept C207001950 @default.
- W2010095512 hasConcept C21951064 @default.
- W2010095512 hasConcept C2779461572 @default.
- W2010095512 hasConcept C54355233 @default.
- W2010095512 hasConcept C552990157 @default.
- W2010095512 hasConcept C55493867 @default.
- W2010095512 hasConcept C71240020 @default.
- W2010095512 hasConcept C86803240 @default.
- W2010095512 hasConceptScore W2010095512C109316439 @default.
- W2010095512 hasConceptScore W2010095512C143425029 @default.
- W2010095512 hasConceptScore W2010095512C162776295 @default.
- W2010095512 hasConceptScore W2010095512C185592680 @default.
- W2010095512 hasConceptScore W2010095512C202751555 @default.
- W2010095512 hasConceptScore W2010095512C207001950 @default.
- W2010095512 hasConceptScore W2010095512C21951064 @default.
- W2010095512 hasConceptScore W2010095512C2779461572 @default.
- W2010095512 hasConceptScore W2010095512C54355233 @default.
- W2010095512 hasConceptScore W2010095512C552990157 @default.
- W2010095512 hasConceptScore W2010095512C55493867 @default.
- W2010095512 hasConceptScore W2010095512C71240020 @default.
- W2010095512 hasConceptScore W2010095512C86803240 @default.
- W2010095512 hasIssue "13" @default.
- W2010095512 hasLocation W20100955121 @default.
- W2010095512 hasOpenAccess W2010095512 @default.
- W2010095512 hasPrimaryLocation W20100955121 @default.
- W2010095512 hasRelatedWork W1982027601 @default.
- W2010095512 hasRelatedWork W1998842974 @default.
- W2010095512 hasRelatedWork W200909032 @default.
- W2010095512 hasRelatedWork W2049529530 @default.
- W2010095512 hasRelatedWork W2071952937 @default.
- W2010095512 hasRelatedWork W2416964709 @default.
- W2010095512 hasRelatedWork W2464301138 @default.
- W2010095512 hasRelatedWork W2517050254 @default.
- W2010095512 hasRelatedWork W2793519975 @default.
- W2010095512 hasRelatedWork W2952304362 @default.
- W2010095512 hasVolume "121" @default.
- W2010095512 isParatext "false" @default.
- W2010095512 isRetracted "false" @default.
- W2010095512 magId "2010095512" @default.
- W2010095512 workType "article" @default.