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- W2010096112 abstract "We examined whether ultraviolet-B (UVB) irradiation (6 kJ/m2) alters cytokine production and other innate immune reactions by murine peritoneal macrophages and peripheral neutrophils. Along with these experiments, serum IgG levels were also assessed. In addition, using scanning electron microscopy (SEM) we observed macrophages that had been exposed to UVB in vitro. Results showed that UVB irradiation: (1) decreased IL-12 production while increasing IL-1α secretion from macrophages, but had no effect on IL-1α from neutrophils; (2) suppressed phagocytosis of macrophages but not of neutrophils; (3) diminished active oxygen production of macrophages but not of neutrophils; (4) had no effect on serum IgG levels; and (5) caused significant cell destruction of macrophages in vitro. These results suggested: (1) that UVB irradiation could induce characteristic suppression of innate immunity; (2) that innate cellular immunity was more susceptible to the effects of UVB irradiation than humoral immunity." @default.
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- W2010096112 date "2001-04-01" @default.
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- W2010096112 title "UVB IRRADIATION SUPPRESSES CYTOKINE PRODUCTION AND INNATE CELLULAR IMMUNE FUNCTIONS IN MICE" @default.
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- W2010096112 doi "https://doi.org/10.1006/cyto.2001.0849" @default.
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