FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010096250> ?p ?o ?g. }

• W2010096250 endingPage "325" @default.
• W2010096250 startingPage "318" @default.
• W2010096250 abstract "The last decades have seen no significant progress in extending the survival of lung cancer patients and there is an urgent need to improve current therapies. The substance P (SP)/neurokinin-1 receptor (NK-1R) system plays an important role in the development of cancer: SP and NK-1R antagonists respectively induce cell proliferation and inhibition in human cancer cell lines. No study of the involvement of this system in non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) cells has been carried out in depth. Here, we demonstrate the involvement of the SP/NK-1R system in human H-69 (SCLC) and COR-L23 (NSCLC) cell lines: (1) they express isoforms of the NK-1R and mRNA for the NK-1R; (2) they overexpress the tachykinin 1 gene; (3) the NK-1R is involved in their viability; (4) SP induces their proliferation; (5) NK-1R antagonists (Aprepitant (Emend), L-733,060, L-732,138) inhibit the growth of both cell lines in a concentration-dependent manner; (6) the specific antitumor action of these antagonists against such cells occurs through the NK-1R; and (7) lung cancer cell death is due to apoptosis. We also demonstrate the presence of NK-1Rs and SP in all the human SCLC and NSCLC samples studied. Our findings indicate that the NK-1R may be a promising new target in the treatment of lung cancer and that NK-1R antagonists could be new candidate antitumor drugs in the treatment of SCLC and NSCLC." @default.
• W2010096250 created "2016-06-24" @default.
• W2010096250 creator A5007827622 @default.
• W2010096250 creator A5017744155 @default.
• W2010096250 creator A5020163776 @default.
• W2010096250 creator A5057489673 @default.
• W2010096250 creator A5065864417 @default.
• W2010096250 creator A5076247452 @default.
• W2010096250 creator A5090666491 @default.
• W2010096250 date "2012-12-01" @default.
• W2010096250 modified "2023-09-26" @default.
• W2010096250 title "The substance P/neurokinin-1 receptor system in lung cancer: Focus on the antitumor action of neurokinin-1 receptor antagonists" @default.
• W2010096250 cites W1965108104 @default.
• W2010096250 cites W1965871971 @default.
• W2010096250 cites W1969358425 @default.
• W2010096250 cites W1973773456 @default.
• W2010096250 cites W1974412135 @default.
• W2010096250 cites W1990000248 @default.
• W2010096250 cites W1992694594 @default.
• W2010096250 cites W2005119541 @default.
• W2010096250 cites W2020835847 @default.
• W2010096250 cites W2024339132 @default.
• W2010096250 cites W2035207044 @default.
• W2010096250 cites W2046952308 @default.
• W2010096250 cites W2048768649 @default.
• W2010096250 cites W2050833196 @default.
• W2010096250 cites W2053889778 @default.
• W2010096250 cites W2054222308 @default.
• W2010096250 cites W2055948011 @default.
• W2010096250 cites W2057519343 @default.
• W2010096250 cites W2058523849 @default.
• W2010096250 cites W2064942304 @default.
• W2010096250 cites W2070384911 @default.
• W2010096250 cites W2096393411 @default.
• W2010096250 cites W2096691041 @default.
• W2010096250 cites W2111723542 @default.
• W2010096250 cites W2114643862 @default.
• W2010096250 cites W2131783891 @default.
• W2010096250 cites W2133791387 @default.
• W2010096250 cites W2159588204 @default.
• W2010096250 cites W2165157874 @default.
• W2010096250 cites W2169127836 @default.
• W2010096250 doi "https://doi.org/10.1016/j.peptides.2012.09.024" @default.
• W2010096250 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23026680" @default.
• W2010096250 hasPublicationYear "2012" @default.
• W2010096250 type Work @default.
• W2010096250 sameAs 2010096250 @default.
• W2010096250 citedByCount "59" @default.
• W2010096250 countsByYear W20100962502013 @default.
• W2010096250 countsByYear W20100962502014 @default.
• W2010096250 countsByYear W20100962502015 @default.
• W2010096250 countsByYear W20100962502016 @default.
• W2010096250 countsByYear W20100962502017 @default.
• W2010096250 countsByYear W20100962502018 @default.
• W2010096250 countsByYear W20100962502019 @default.
• W2010096250 countsByYear W20100962502020 @default.
• W2010096250 countsByYear W20100962502021 @default.
• W2010096250 countsByYear W20100962502022 @default.
• W2010096250 countsByYear W20100962502023 @default.
• W2010096250 crossrefType "journal-article" @default.
• W2010096250 hasAuthorship W2010096250A5007827622 @default.
• W2010096250 hasAuthorship W2010096250A5017744155 @default.
• W2010096250 hasAuthorship W2010096250A5020163776 @default.
• W2010096250 hasAuthorship W2010096250A5057489673 @default.
• W2010096250 hasAuthorship W2010096250A5065864417 @default.
• W2010096250 hasAuthorship W2010096250A5076247452 @default.
• W2010096250 hasAuthorship W2010096250A5090666491 @default.
• W2010096250 hasConcept C118303440 @default.
• W2010096250 hasConcept C121608353 @default.
• W2010096250 hasConcept C126322002 @default.
• W2010096250 hasConcept C137130169 @default.
• W2010096250 hasConcept C170493617 @default.
• W2010096250 hasConcept C190283241 @default.
• W2010096250 hasConcept C2776256026 @default.
• W2010096250 hasConcept C2776533618 @default.
• W2010096250 hasConcept C2776694085 @default.
• W2010096250 hasConcept C2777056410 @default.
• W2010096250 hasConcept C2780574406 @default.
• W2010096250 hasConcept C2780884295 @default.
• W2010096250 hasConcept C502942594 @default.
• W2010096250 hasConcept C54355233 @default.
• W2010096250 hasConcept C55493867 @default.
• W2010096250 hasConcept C55938493 @default.
• W2010096250 hasConcept C71924100 @default.
• W2010096250 hasConcept C81885089 @default.
• W2010096250 hasConcept C86803240 @default.
• W2010096250 hasConcept C96232424 @default.
• W2010096250 hasConcept C98274493 @default.
• W2010096250 hasConceptScore W2010096250C118303440 @default.
• W2010096250 hasConceptScore W2010096250C121608353 @default.
• W2010096250 hasConceptScore W2010096250C126322002 @default.
• W2010096250 hasConceptScore W2010096250C137130169 @default.
• W2010096250 hasConceptScore W2010096250C170493617 @default.
• W2010096250 hasConceptScore W2010096250C190283241 @default.
• W2010096250 hasConceptScore W2010096250C2776256026 @default.
• W2010096250 hasConceptScore W2010096250C2776533618 @default.
• W2010096250 hasConceptScore W2010096250C2776694085 @default.
• W2010096250 hasConceptScore W2010096250C2777056410 @default.

• next