FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010097921> ?p ?o ?g. }

• W2010097921 endingPage "333" @default.
• W2010097921 startingPage "328" @default.
• W2010097921 abstract "Background: Grade IV chemotherapy toxicity is defined as absolute neutrophil count <500/μL. The nadir is considered as the lowest neutrophil number following chemotherapy, and generally is not expected before the 7th day from the start of chemotherapy. The usual prophylactic dose of rHu-G-CSF (Filgrastim) is 300 μg/day, starting 24–48 h after chemotherapy until hematological recovery. However, individual patient response is largely variable, so that rHu-G-CSF doses can be different. The aim of this study was to verify if peripheral blood automated flow cytochemistry and flow cytometry analysis may be helpful in predicting the individual response and saving rHu-G-CSF. Methods: During Grade IV neutropenia, blood counts from 30 cancer patients were analyzed daily by ADVIA 120 automated flow cytochemistry analyzer and by Facscalibur flow cytometer till the nadir. “Large unstained cells” (LUCs), myeloperoxidase index (MPXI), blasts, and various cell subpopulations in the peripheral blood were studied. At nadir rHu-G-CSF was started and 81 chemotherapy cycles were analyzed. Cycles were stratified according to their number and to two dose-levels of rHuG-CSF needed to recovery (300–600 vs. 900–1200 μg) and analyzed in relation to mean values of MPXI and mean absolute number of LUCs in the nadir phase. The linear regressions of LUCs % over time in relation to two dose-levels of rHu-G-CSF and uni-multivariate analysis of lymphocyte subpopulations, CD34+ cells, MPXI, and blasts were also performed. Results: In the nadir phase, the increase of MPXI above the upper limit of normality (>10; median 27.7), characterized a slow hematological recovery. MPXI levels were directly related to the cycle number and inversely related to the absolute number of LUCs and CD34+/CD45+ cells. A faster hematological recovery was associated with a higher LUC increase per day (0.56% vs. 0.25%), higher blast (median 36.7/μL vs. 19.5/μL) and CD34+/CD45+ cell (median 2.2/μL vs. 0.82/μL) counts. Conclusions: Our study showed that some biological indicators such as MPXI, LUCs, blasts, and CD34+/CD45+ cells may be of clinical relevance in predicting individual hematological response to rHu-G-CSF. Special attention should be paid when nadir MPXI exceeds the upper limit of normality because the hematological recovery may be delayed. © 2009 Clinical Cytometry Society" @default.
• W2010097921 created "2016-06-24" @default.
• W2010097921 creator A5009315392 @default.
• W2010097921 creator A5020711568 @default.
• W2010097921 creator A5024214894 @default.
• W2010097921 creator A5024329203 @default.
• W2010097921 creator A5029969206 @default.
• W2010097921 creator A5032815593 @default.
• W2010097921 creator A5036277223 @default.
• W2010097921 creator A5039426761 @default.
• W2010097921 creator A5040523906 @default.
• W2010097921 creator A5052878762 @default.
• W2010097921 creator A5053395820 @default.
• W2010097921 creator A5054981291 @default.
• W2010097921 creator A5068967348 @default.
• W2010097921 creator A5070334521 @default.
• W2010097921 creator A5086098622 @default.
• W2010097921 creator A5090303708 @default.
• W2010097921 date "2009-09-01" @default.
• W2010097921 modified "2023-10-16" @default.
• W2010097921 title "Predictive value of hematological and phenotypical parameters on postchemotherapy leukocyte recovery" @default.
• W2010097921 cites W109627310 @default.
• W2010097921 cites W1855441706 @default.
• W2010097921 cites W1967820788 @default.
• W2010097921 cites W1986753163 @default.
• W2010097921 cites W1997869846 @default.
• W2010097921 cites W2010424931 @default.
• W2010097921 cites W202042235 @default.
• W2010097921 cites W2024933507 @default.
• W2010097921 cites W2036509237 @default.
• W2010097921 cites W2037616254 @default.
• W2010097921 cites W2081538983 @default.
• W2010097921 cites W2099774228 @default.
• W2010097921 cites W2102184759 @default.
• W2010097921 cites W2138050911 @default.
• W2010097921 cites W2142195688 @default.
• W2010097921 cites W2150470001 @default.
• W2010097921 cites W2155006578 @default.
• W2010097921 cites W2287952793 @default.
• W2010097921 cites W2332918386 @default.
• W2010097921 doi "https://doi.org/10.1002/cyto.b.20476" @default.
• W2010097921 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19358298" @default.
• W2010097921 hasPublicationYear "2009" @default.
• W2010097921 type Work @default.
• W2010097921 sameAs 2010097921 @default.
• W2010097921 citedByCount "10" @default.
• W2010097921 countsByYear W20100979212012 @default.
• W2010097921 countsByYear W20100979212013 @default.
• W2010097921 countsByYear W20100979212014 @default.
• W2010097921 countsByYear W20100979212015 @default.
• W2010097921 countsByYear W20100979212021 @default.
• W2010097921 countsByYear W20100979212023 @default.
• W2010097921 crossrefType "journal-article" @default.
• W2010097921 hasAuthorship W2010097921A5009315392 @default.
• W2010097921 hasAuthorship W2010097921A5020711568 @default.
• W2010097921 hasAuthorship W2010097921A5024214894 @default.
• W2010097921 hasAuthorship W2010097921A5024329203 @default.
• W2010097921 hasAuthorship W2010097921A5029969206 @default.
• W2010097921 hasAuthorship W2010097921A5032815593 @default.
• W2010097921 hasAuthorship W2010097921A5036277223 @default.
• W2010097921 hasAuthorship W2010097921A5039426761 @default.
• W2010097921 hasAuthorship W2010097921A5040523906 @default.
• W2010097921 hasAuthorship W2010097921A5052878762 @default.
• W2010097921 hasAuthorship W2010097921A5053395820 @default.
• W2010097921 hasAuthorship W2010097921A5054981291 @default.
• W2010097921 hasAuthorship W2010097921A5068967348 @default.
• W2010097921 hasAuthorship W2010097921A5070334521 @default.
• W2010097921 hasAuthorship W2010097921A5086098622 @default.
• W2010097921 hasAuthorship W2010097921A5090303708 @default.
• W2010097921 hasBestOaLocation W20100979211 @default.
• W2010097921 hasConcept C126322002 @default.
• W2010097921 hasConcept C127413603 @default.
• W2010097921 hasConcept C146978453 @default.
• W2010097921 hasConcept C19269812 @default.
• W2010097921 hasConcept C203014093 @default.
• W2010097921 hasConcept C2776694085 @default.
• W2010097921 hasConcept C2777063308 @default.
• W2010097921 hasConcept C2777761686 @default.
• W2010097921 hasConcept C2779171977 @default.
• W2010097921 hasConcept C3017910909 @default.
• W2010097921 hasConcept C553184892 @default.
• W2010097921 hasConcept C71924100 @default.
• W2010097921 hasConcept C74133956 @default.
• W2010097921 hasConcept C88575799 @default.
• W2010097921 hasConcept C90924648 @default.
• W2010097921 hasConceptScore W2010097921C126322002 @default.
• W2010097921 hasConceptScore W2010097921C127413603 @default.
• W2010097921 hasConceptScore W2010097921C146978453 @default.
• W2010097921 hasConceptScore W2010097921C19269812 @default.
• W2010097921 hasConceptScore W2010097921C203014093 @default.
• W2010097921 hasConceptScore W2010097921C2776694085 @default.
• W2010097921 hasConceptScore W2010097921C2777063308 @default.
• W2010097921 hasConceptScore W2010097921C2777761686 @default.
• W2010097921 hasConceptScore W2010097921C2779171977 @default.
• W2010097921 hasConceptScore W2010097921C3017910909 @default.
• W2010097921 hasConceptScore W2010097921C553184892 @default.
• W2010097921 hasConceptScore W2010097921C71924100 @default.
• W2010097921 hasConceptScore W2010097921C74133956 @default.

• next