FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010102541> ?p ?o ?g. }

• W2010102541 abstract "The discovery of the tissue-protective activities of erythropoietin (EPO) has underlined the importance of some cytokines in tissue protection, repair and remodeling. As such activities have been reported for other cytokines, we asked whether we could define a class of tissue-protective cytokines. We therefore explored a novel approach based on functional clustering. In this pilot study, we started by analyzing a small number of cytokines (30). We functionally classified the 30 cytokines according to their interactions by using the bioinformatics tool STRING (Search Tool for the Retrieval of Interacting Genes), followed by hierarchical cluster analysis. The results of this functional clustering were different from those obtained by clustering cytokines simply according to their sequence. We previously reported that the protective activity of EPO in a model of cerebral ischemia was paralleled by an upregulation of synaptic plasticity genes, particularly early growth response 2 (EGR2). To assess the predictivity of functional clustering, we tested some of the cytokines clustering close to EPO (interleukin-11, IL-11; kit ligand, KITLG; leukemia inhibitory factor, LIF; thrombopoietin, THPO) in an in vitro model of human neuronal cells for their ability to induce EGR2. Two of these, LIF and IL-11, induced EGR2 expression. Although these data would need to be extended to a larger number of cytokines and the biological validation should be done using more robust in vivo models, rather then just one cell line, this study shows the feasibility of this approach. This type of functional cluster analysis could be extended to other fields of cytokine research and help design biological experiments." @default.
• W2010102541 created "2016-06-24" @default.
• W2010102541 creator A5006512036 @default.
• W2010102541 creator A5026488314 @default.
• W2010102541 creator A5049977155 @default.
• W2010102541 creator A5068280856 @default.
• W2010102541 creator A5085283148 @default.
• W2010102541 date "2014-03-17" @default.
• W2010102541 modified "2023-09-26" @default.
• W2010102541 title "Definition of a Family of Tissue-Protective Cytokines Using Functional Cluster Analysis: A Proof-of-Concept Study" @default.
• W2010102541 cites W152340129 @default.
• W2010102541 cites W1603632991 @default.
• W2010102541 cites W18558867 @default.
• W2010102541 cites W1926103424 @default.
• W2010102541 cites W1967334494 @default.
• W2010102541 cites W1967342482 @default.
• W2010102541 cites W1996131506 @default.
• W2010102541 cites W1998581885 @default.
• W2010102541 cites W2001668845 @default.
• W2010102541 cites W2010475095 @default.
• W2010102541 cites W2031070508 @default.
• W2010102541 cites W2037155998 @default.
• W2010102541 cites W2047342629 @default.
• W2010102541 cites W2057545775 @default.
• W2010102541 cites W2087633509 @default.
• W2010102541 cites W2087877138 @default.
• W2010102541 cites W2094196490 @default.
• W2010102541 cites W2109723592 @default.
• W2010102541 cites W2110788486 @default.
• W2010102541 cites W2121188367 @default.
• W2010102541 cites W2142463112 @default.
• W2010102541 cites W2158217645 @default.
• W2010102541 cites W2164812741 @default.
• W2010102541 cites W2316067769 @default.
• W2010102541 cites W4242930333 @default.
• W2010102541 doi "https://doi.org/10.3389/fimmu.2014.00115" @default.
• W2010102541 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3955874" @default.
• W2010102541 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24672526" @default.
• W2010102541 hasPublicationYear "2014" @default.
• W2010102541 type Work @default.
• W2010102541 sameAs 2010102541 @default.
• W2010102541 citedByCount "7" @default.
• W2010102541 countsByYear W20101025412014 @default.
• W2010102541 countsByYear W20101025412015 @default.
• W2010102541 countsByYear W20101025412016 @default.
• W2010102541 countsByYear W20101025412017 @default.
• W2010102541 countsByYear W20101025412018 @default.
• W2010102541 crossrefType "journal-article" @default.
• W2010102541 hasAuthorship W2010102541A5006512036 @default.
• W2010102541 hasAuthorship W2010102541A5026488314 @default.
• W2010102541 hasAuthorship W2010102541A5049977155 @default.
• W2010102541 hasAuthorship W2010102541A5068280856 @default.
• W2010102541 hasAuthorship W2010102541A5085283148 @default.
• W2010102541 hasBestOaLocation W20101025411 @default.
• W2010102541 hasConcept C104317684 @default.
• W2010102541 hasConcept C11988809 @default.
• W2010102541 hasConcept C127561419 @default.
• W2010102541 hasConcept C154945302 @default.
• W2010102541 hasConcept C164027704 @default.
• W2010102541 hasConcept C169760540 @default.
• W2010102541 hasConcept C203014093 @default.
• W2010102541 hasConcept C27284151 @default.
• W2010102541 hasConcept C2776914184 @default.
• W2010102541 hasConcept C2778534260 @default.
• W2010102541 hasConcept C2778690821 @default.
• W2010102541 hasConcept C41008148 @default.
• W2010102541 hasConcept C54355233 @default.
• W2010102541 hasConcept C60644358 @default.
• W2010102541 hasConcept C70721500 @default.
• W2010102541 hasConcept C73555534 @default.
• W2010102541 hasConcept C86803240 @default.
• W2010102541 hasConcept C92835128 @default.
• W2010102541 hasConceptScore W2010102541C104317684 @default.
• W2010102541 hasConceptScore W2010102541C11988809 @default.
• W2010102541 hasConceptScore W2010102541C127561419 @default.
• W2010102541 hasConceptScore W2010102541C154945302 @default.
• W2010102541 hasConceptScore W2010102541C164027704 @default.
• W2010102541 hasConceptScore W2010102541C169760540 @default.
• W2010102541 hasConceptScore W2010102541C203014093 @default.
• W2010102541 hasConceptScore W2010102541C27284151 @default.
• W2010102541 hasConceptScore W2010102541C2776914184 @default.
• W2010102541 hasConceptScore W2010102541C2778534260 @default.
• W2010102541 hasConceptScore W2010102541C2778690821 @default.
• W2010102541 hasConceptScore W2010102541C41008148 @default.
• W2010102541 hasConceptScore W2010102541C54355233 @default.
• W2010102541 hasConceptScore W2010102541C60644358 @default.
• W2010102541 hasConceptScore W2010102541C70721500 @default.
• W2010102541 hasConceptScore W2010102541C73555534 @default.
• W2010102541 hasConceptScore W2010102541C86803240 @default.
• W2010102541 hasConceptScore W2010102541C92835128 @default.
• W2010102541 hasLocation W20101025411 @default.
• W2010102541 hasLocation W20101025412 @default.
• W2010102541 hasLocation W20101025413 @default.
• W2010102541 hasLocation W20101025414 @default.
• W2010102541 hasLocation W20101025415 @default.
• W2010102541 hasOpenAccess W2010102541 @default.
• W2010102541 hasPrimaryLocation W20101025411 @default.
• W2010102541 hasRelatedWork W1822915860 @default.
• W2010102541 hasRelatedWork W1984501713 @default.
• W2010102541 hasRelatedWork W2011513035 @default.

• next