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• W2010108246 endingPage "2826" @default.
• W2010108246 startingPage "2822" @default.
• W2010108246 abstract "Specific DNA binding to the core consensus site GAGAGAG has been shown with an 82-residue peptide (residues 310-391) taken from the Drosophila transcription factor GAGA. Using a series of deletion mutants, it was demonstrated that the minimal domain required for specific binding (residues 310-372) includes a single zinc finger of the Cys2-His2 family and a stretch of basic amino acids located on the N-terminal end of the zinc finger. In gel retardation assays, the specific binding seen with either the peptide or the whole protein is zinc dependent and corresponds to a dissociation constant of approximately 5 x 10(-9) M for the purified peptide. It has previously been thought that a single zinc finger of the Cys2-His2 family is incapable of specific, high-affinity binding to DNA. The combination of an N-terminal basic region with a single Cys2-His2 zinc finger in the GAGA protein can thus be viewed as a novel DNA binding domain. This raises the possibility that other proteins carrying only one Cys2-His2 finger are also capable of high-affinity specific binding to DNA." @default.
• W2010108246 created "2016-06-24" @default.
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• W2010108246 date "1996-04-02" @default.
• W2010108246 modified "2023-10-16" @default.
• W2010108246 title "The single Cys2-His2 zinc finger domain of the GAGA protein flanked by basic residues is sufficient for high-affinity specific DNA binding." @default.
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• W2010108246 doi "https://doi.org/10.1073/pnas.93.7.2822" @default.
• W2010108246 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/39717" @default.
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