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• W2010120124 abstract "Rats placed on a purified diet deficient in pantothenic acid from the day of birth showed the following changes in the oral epithelium 1. Early hyperkeratosis of enamel and mouth epithelium, noted in several rats as young as 21 to 48 days of age. 2. Necrosis of epithelium, first seen at 48 days, advancing deeper and appearing with greater frequency in older rats. 3. In several rats surviving more than 72 days, the necrotic process had advanced deeply, destroying all epithelial cells of the interdental papilla and the underlying connective tissue down to the crest of the alveolar bone. 4. Resorption of the alveolar crest had occurred in the advanced stages of tissue destruction in a few rats. 5. At all stages up to the complete destruction of the epithelium the vital cells of the basal layer had proliferated, thus protecting the underlying tissues from exposure to the oral cavity. 6. An unusual absence of inflammatory response was noted, notwithstanding the presence of marked destruction of tissue. 7. The changes in pantothenic acid deficiency differ markedly from those in dogs resulting from lack of niacin; which, although it is also a member of the B group of vitamins, results in a severe inflammatory response with hyperemia and edema. Rats placed on the deficient diet from weaning showed: 1. The typical necrosis of epithelium, confirming the pathologic picture observed in the rats deficient from birth. 2. These changes occurred on superior basal diets high in either carbohydrate (64 per cent sucrose) or fat (48 per cent fat, 24 per cent sucrose) and in spite of deferring the start of the deficiency, thus enabling the animal to mature further. 3. Epithelial spurs from the surface and enlargements of Malassez's rests were observed. The outstanding characteristic changes in pantothenic acid deficient rats, which confirm the earlier findings on the older filtrate fraction deficient dogs and emphasize the constancy of the pathologic changes, are: progressive necrosis of the oral epithelium and subsequent destruction of the underlying connective tissues with an extraordinary absence of inflammatory response." @default.
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• W2010120124 date "1945-07-01" @default.
• W2010120124 modified "2023-09-23" @default.
• W2010120124 title "Changes in the oral mucosa accompanying acute pantothenic acid deficiency in young rats" @default.
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• W2010120124 doi "https://doi.org/10.1016/0096-6347(45)90223-7" @default.
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