FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010129213> ?p ?o ?g. }

• W2010129213 endingPage "488" @default.
• W2010129213 startingPage "477" @default.
• W2010129213 abstract "The main transplantation strategy in Parkinson's disease has been to place dopaminergic grafts not in their ontogenic site, the substantia nigra, but in their target area, the striatum with contrasting results. Here we have used green fluorescent protein transgenic mouse embryos as donors of ventral mesencephalic cells for transplantation into the pre-lesioned substantia nigra of an adult wild-type host. This allows distinguishing the transplanted cells and their projections from those of the host. Grafted cells integrated within the host mesencephalon and expressed the dopaminergic markers tyrosine hydroxylase, vesicular monoamine transporter 2 and dopamine transporter. Most of the dopaminergic cells within the transplant expressed the substantia nigra marker Girk2 while a lesser proportion expressed the ventral tegmental area marker calbindin. Mesencephalic transplants developed projections through the medial forebrain bundle to the striatum, increased striatal dopamine levels and restored normal behavior. Interestingly, only mesencephalic transplants were able to restore the nigrostriatal projections as dopamine neurons originating from embryonic olfactory bulb transplants send projections only in the close vicinity of the transplantation site that did not reach the striatum. Our results show for the first time the ability of intranigral foetal dopaminergic neurons grafts to restore the damaged nigrostriatal pathway in adult mice. Together with our previous findings of efficient embryonic transplantation within the pre-lesioned adult motor cortex, these results demonstrate that the adult brain is permissive to specific and long distance axonal growth. They further open new avenues in cell transplantation therapies applied for the treatment of neurodegenerative disorders such as Parkinson's disease." @default.
• W2010129213 created "2016-06-24" @default.
• W2010129213 creator A5030715609 @default.
• W2010129213 creator A5052137323 @default.
• W2010129213 creator A5057021809 @default.
• W2010129213 creator A5058715703 @default.
• W2010129213 creator A5061597136 @default.
• W2010129213 creator A5063328073 @default.
• W2010129213 creator A5084744256 @default.
• W2010129213 date "2009-09-01" @default.
• W2010129213 modified "2023-10-18" @default.
• W2010129213 title "Anatomical and functional reconstruction of the nigrostriatal pathway by intranigral transplants" @default.
• W2010129213 cites W1488674536 @default.
• W2010129213 cites W1533708729 @default.
• W2010129213 cites W1534688029 @default.
• W2010129213 cites W1555203554 @default.
• W2010129213 cites W1675455120 @default.
• W2010129213 cites W1772016182 @default.
• W2010129213 cites W1817961777 @default.
• W2010129213 cites W1970074941 @default.
• W2010129213 cites W1970979709 @default.
• W2010129213 cites W1973897139 @default.
• W2010129213 cites W1977524150 @default.
• W2010129213 cites W1977776486 @default.
• W2010129213 cites W1978318953 @default.
• W2010129213 cites W1981236607 @default.
• W2010129213 cites W1983779076 @default.
• W2010129213 cites W1985351922 @default.
• W2010129213 cites W1985561353 @default.
• W2010129213 cites W2000156766 @default.
• W2010129213 cites W2025469506 @default.
• W2010129213 cites W2033850774 @default.
• W2010129213 cites W2036754472 @default.
• W2010129213 cites W2036848292 @default.
• W2010129213 cites W2044407202 @default.
• W2010129213 cites W2046047050 @default.
• W2010129213 cites W2046302119 @default.
• W2010129213 cites W2049397888 @default.
• W2010129213 cites W2050647292 @default.
• W2010129213 cites W2052029809 @default.
• W2010129213 cites W2065601975 @default.
• W2010129213 cites W2066113689 @default.
• W2010129213 cites W2076397245 @default.
• W2010129213 cites W2080199879 @default.
• W2010129213 cites W2082139619 @default.
• W2010129213 cites W2085285204 @default.
• W2010129213 cites W2107486301 @default.
• W2010129213 cites W2107499423 @default.
• W2010129213 cites W2108851964 @default.
• W2010129213 cites W2111405228 @default.
• W2010129213 cites W2116246431 @default.
• W2010129213 cites W2149246998 @default.
• W2010129213 cites W2159884201 @default.
• W2010129213 cites W2162679852 @default.
• W2010129213 cites W2166496419 @default.
• W2010129213 cites W2168341415 @default.
• W2010129213 cites W2171298950 @default.
• W2010129213 cites W4231677736 @default.
• W2010129213 cites W4376633690 @default.
• W2010129213 cites W62603772 @default.
• W2010129213 doi "https://doi.org/10.1016/j.nbd.2009.07.003" @default.
• W2010129213 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19616502" @default.
• W2010129213 hasPublicationYear "2009" @default.
• W2010129213 type Work @default.
• W2010129213 sameAs 2010129213 @default.
• W2010129213 citedByCount "65" @default.
• W2010129213 countsByYear W20101292132012 @default.
• W2010129213 countsByYear W20101292132013 @default.
• W2010129213 countsByYear W20101292132014 @default.
• W2010129213 countsByYear W20101292132015 @default.
• W2010129213 countsByYear W20101292132016 @default.
• W2010129213 countsByYear W20101292132017 @default.
• W2010129213 countsByYear W20101292132018 @default.
• W2010129213 countsByYear W20101292132019 @default.
• W2010129213 countsByYear W20101292132020 @default.
• W2010129213 countsByYear W20101292132021 @default.
• W2010129213 countsByYear W20101292132022 @default.
• W2010129213 countsByYear W20101292132023 @default.
• W2010129213 crossrefType "journal-article" @default.
• W2010129213 hasAuthorship W2010129213A5030715609 @default.
• W2010129213 hasAuthorship W2010129213A5052137323 @default.
• W2010129213 hasAuthorship W2010129213A5057021809 @default.
• W2010129213 hasAuthorship W2010129213A5058715703 @default.
• W2010129213 hasAuthorship W2010129213A5061597136 @default.
• W2010129213 hasAuthorship W2010129213A5063328073 @default.
• W2010129213 hasAuthorship W2010129213A5084744256 @default.
• W2010129213 hasConcept C126322002 @default.
• W2010129213 hasConcept C137183658 @default.
• W2010129213 hasConcept C169760540 @default.
• W2010129213 hasConcept C2776355744 @default.
• W2010129213 hasConcept C2776669363 @default.
• W2010129213 hasConcept C2776755682 @default.
• W2010129213 hasConcept C2780062018 @default.
• W2010129213 hasConcept C2780938664 @default.
• W2010129213 hasConcept C2780948874 @default.
• W2010129213 hasConcept C2911091166 @default.
• W2010129213 hasConcept C513476851 @default.
• W2010129213 hasConcept C71924100 @default.

• next