FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010131312> ?p ?o ?g. }

• W2010131312 endingPage "376" @default.
• W2010131312 startingPage "372" @default.
• W2010131312 abstract "Studies have shown that the acute administration of venlafaxine elicits an antidepressant-like effect in the mouse forced swim test (FST) by a mechanism dependent on the l-arginine–nitric oxide (NO)–cyclic guanosine monophosphate (cGMP) pathway. Because it has been reported that NO activates different types of potassium (K+) channels in the brain, this study investigated the involvement of K+ channels in the antidepressant-like effect of venlafaxine in the mouse FST. Male adult Swiss mice were pretreated with different K+ channel inhibitors or openers 15 min before venlafaxine administration. After 30 min, the open-field test (OFT) and FST were carried out. Intracerebroventricular (i.c.v.) pretreatment of mice with subeffective doses of tetraethylammonium (TEA, a non-specific inhibitor of K+ channels, 25 pg/site), glibenclamide (an ATP-sensitive K+ channel inhibitor, 0.5 pg/site), charybdotoxin (a large- and intermediate-conductance calcium-activated K+ channel inhibitor, 25 pg/site) or apamin (a small-conductance calcium-activated K+ channel inhibitor, 10 pg/site) was able to potentiate the action of a subeffective dose of venlafaxine (2 mg/kg, i.p.). Moreover, the reduction in the immobility time elicited by an effective dose of venlafaxine (8 mg/kg, i.p.) in the FST was prevented by the pretreatment of mice with the K+ channel openers cromakalim (10 µg/site, i.c.v.) and minoxidil (10 µg/site, i.c.v.). The drugs used in this study did not produce any change in locomotor activity. The results demonstrate that the neuromodulatory effects of venlafaxine, via the inhibition of K+ channels, are possibly involved in its anti-immobility activity in the mouse FST." @default.
• W2010131312 created "2016-06-24" @default.
• W2010131312 creator A5001474047 @default.
• W2010131312 creator A5038329537 @default.
• W2010131312 creator A5057944622 @default.
• W2010131312 creator A5079224102 @default.
• W2010131312 date "2010-02-01" @default.
• W2010131312 modified "2023-09-23" @default.
• W2010131312 title "Involvement of potassium channels in the antidepressant-like effect of venlafaxine in mice" @default.
• W2010131312 cites W1965171169 @default.
• W2010131312 cites W1979420282 @default.
• W2010131312 cites W1979459872 @default.
• W2010131312 cites W1980446425 @default.
• W2010131312 cites W1980825603 @default.
• W2010131312 cites W1983899648 @default.
• W2010131312 cites W1989724927 @default.
• W2010131312 cites W1990366821 @default.
• W2010131312 cites W1991412103 @default.
• W2010131312 cites W2006957979 @default.
• W2010131312 cites W2022200963 @default.
• W2010131312 cites W2026040538 @default.
• W2010131312 cites W2029574067 @default.
• W2010131312 cites W2041565530 @default.
• W2010131312 cites W2047905951 @default.
• W2010131312 cites W2049329288 @default.
• W2010131312 cites W2050677124 @default.
• W2010131312 cites W2061118607 @default.
• W2010131312 cites W2063503589 @default.
• W2010131312 cites W2067577695 @default.
• W2010131312 cites W2075150149 @default.
• W2010131312 cites W2075873613 @default.
• W2010131312 cites W2076177667 @default.
• W2010131312 cites W2081884263 @default.
• W2010131312 cites W2083048709 @default.
• W2010131312 cites W2084175980 @default.
• W2010131312 cites W2089299823 @default.
• W2010131312 cites W2093839167 @default.
• W2010131312 cites W2094286646 @default.
• W2010131312 cites W2112217983 @default.
• W2010131312 cites W2112706629 @default.
• W2010131312 cites W2127872798 @default.
• W2010131312 cites W2151482983 @default.
• W2010131312 cites W2153003059 @default.
• W2010131312 cites W2403635862 @default.
• W2010131312 cites W4238542215 @default.
• W2010131312 doi "https://doi.org/10.1016/j.lfs.2010.01.013" @default.
• W2010131312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20102723" @default.
• W2010131312 hasPublicationYear "2010" @default.
• W2010131312 type Work @default.
• W2010131312 sameAs 2010131312 @default.
• W2010131312 citedByCount "16" @default.
• W2010131312 countsByYear W20101313122012 @default.
• W2010131312 countsByYear W20101313122015 @default.
• W2010131312 countsByYear W20101313122016 @default.
• W2010131312 countsByYear W20101313122017 @default.
• W2010131312 countsByYear W20101313122018 @default.
• W2010131312 countsByYear W20101313122019 @default.
• W2010131312 countsByYear W20101313122020 @default.
• W2010131312 countsByYear W20101313122022 @default.
• W2010131312 countsByYear W20101313122023 @default.
• W2010131312 crossrefType "journal-article" @default.
• W2010131312 hasAuthorship W2010131312A5001474047 @default.
• W2010131312 hasAuthorship W2010131312A5038329537 @default.
• W2010131312 hasAuthorship W2010131312A5057944622 @default.
• W2010131312 hasAuthorship W2010131312A5079224102 @default.
• W2010131312 hasConcept C134018914 @default.
• W2010131312 hasConcept C136569192 @default.
• W2010131312 hasConcept C178790620 @default.
• W2010131312 hasConcept C185592680 @default.
• W2010131312 hasConcept C2776466888 @default.
• W2010131312 hasConcept C2776919887 @default.
• W2010131312 hasConcept C2778457506 @default.
• W2010131312 hasConcept C2779177272 @default.
• W2010131312 hasConcept C2779768347 @default.
• W2010131312 hasConcept C2780419564 @default.
• W2010131312 hasConcept C2780561956 @default.
• W2010131312 hasConcept C2781161787 @default.
• W2010131312 hasConcept C2781295685 @default.
• W2010131312 hasConcept C517785266 @default.
• W2010131312 hasConcept C555293320 @default.
• W2010131312 hasConcept C71924100 @default.
• W2010131312 hasConcept C83743174 @default.
• W2010131312 hasConcept C98274493 @default.
• W2010131312 hasConceptScore W2010131312C134018914 @default.
• W2010131312 hasConceptScore W2010131312C136569192 @default.
• W2010131312 hasConceptScore W2010131312C178790620 @default.
• W2010131312 hasConceptScore W2010131312C185592680 @default.
• W2010131312 hasConceptScore W2010131312C2776466888 @default.
• W2010131312 hasConceptScore W2010131312C2776919887 @default.
• W2010131312 hasConceptScore W2010131312C2778457506 @default.
• W2010131312 hasConceptScore W2010131312C2779177272 @default.
• W2010131312 hasConceptScore W2010131312C2779768347 @default.
• W2010131312 hasConceptScore W2010131312C2780419564 @default.
• W2010131312 hasConceptScore W2010131312C2780561956 @default.
• W2010131312 hasConceptScore W2010131312C2781161787 @default.
• W2010131312 hasConceptScore W2010131312C2781295685 @default.
• W2010131312 hasConceptScore W2010131312C517785266 @default.
• W2010131312 hasConceptScore W2010131312C555293320 @default.

• next