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- W2010136044 abstract "Summary This article attempts to assemble theoretical‐teleological argument to explore possible answers to the question of why class I MHC molecules bind smaller peptides than class II MHC molecules and the associated question of why the size of peptides binding to class I molecules is approaching the limit of the self‐non‐self discrimination. I propose that the small size of most class I‐binding peptides precludes the production of ‘MHC‐restricted’ antibodies. Such a strategy avoids the possibility of antibodies binding to the epitopes recognized by CD8 + T cells, thus blocking effector function required for clearance of potentially lethal infections." @default.
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- W2010136044 date "1995-02-01" @default.
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- W2010136044 title "Why do class I MHC molecules bind smaller peptides than class II MHC molecules?" @default.
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- W2010136044 doi "https://doi.org/10.1038/icb.1995.15" @default.
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