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- W2010142723 abstract "Recent studies suggest that the KIBRA SNP rs17070145 minor allele (T) is associated with better episodic memory and biologically-consistent fMRI activation patterns during episodic memory tasks. KIBRA mRNA expression is also higher in memory-related brain regions. Several studies also reported decreased risk of AD associated with the minor allele of rs1707145. These findings need further replication in independent series, including non-Caucasian populations. Twenty-five variants within and flanking KIBRA were genotyped in 1 African-American (n>200 AD cases vs. n>400 controls) and 7 Caucasian (n>4500 AD vs. n>5000 controls) series composed of subjects with age at diagnosis/entry of ≥60. KIBRA mRNA expression levels were measured in the human post-mortem temporal cortex and cerebellum. AD risk/SNP association was tested in logistic regression models using age, gender, and ApoE as covariates. Episodic memory (delayed scores from the Auditory Verbal Learning Test) was also tested for association in the African-American and 4 Caucasian series. Among Caucasians, KIBRA SNP rs17070145 minor T allele showed marginal association with AD risk that was in the same direction as in prior studies (OR, 95% confidence interval (CI) = 0.98, 0.89-1.07). This association appeared to be age-dependent and stronger in subjects with age at diagnosis/entry of ≥80 (OR, 95% CI = 0.87, 0.76-1.01). Among African Americans, the T allele also showed a protective trend (OR, 95% = 0.76, 0.53-1.09) in all subjects, and had a significant effect in subjects age ≥80 (OR, 95% = 0.47, 0.23-0.99). Association with episodic memory was significant only in one Caucasian series composed of subjects with age ≥80 (p = 0.03). KIBRA mRNA expression levels were significantly higher in the temporal cortex of 87 ADs vs. 85 non-ADs (p = 0.002), and showed the same trend in the cerebella (87 ADs vs. 73 non-ADs, p = 0.06). Although modest, KIBRA variant rs17070145 demonstrates association with AD risk and episodic memory, with stronger effects among older subjects. Furthermore, we demonstrate differential expression of KIBRA mRNA between ADs and non-ADs particularly in memory-related brain regions. Overall, the current results provide additional evidence suggesting a role for KIBRA as a gene that influences both memory and risk of AD." @default.
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- W2010142723 date "2010-07-01" @default.
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- W2010142723 title "P1-098: Association of common KIBRA variants with episodic memory and Alzheimer risk" @default.
- W2010142723 doi "https://doi.org/10.1016/j.jalz.2010.05.646" @default.
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