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- W2010143989 abstract "To reduce the number of patients needed in a clinical trial, a sequential plan is sometimes used. This paper deals with the truncation of a sequential two sample Wilcoxon test which was originally an open plan (SKOVLUND and WALLOE, 1988). The truncated boundaries have been developed by stochastic simulation. These boundaries form a triangular continuation region. The simulated constants of the boundaries are presented in a table which may be used directly. Boundaries for truncation at 50, 100, 150 and 200 patients are developed. The chosen significance level may be 0.01, 0.025 or 0.05, and the power 0.95. To extend the applicability to other treatment differences than those tabulated, smooth curves are fitted to the simulated points. These make the test applicable to any treatment difference within the simulated range." @default.
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- W2010143989 date "1991-01-01" @default.
- W2010143989 modified "2023-09-27" @default.
- W2010143989 title "Truncation of a Two Sample Sequential Wilcoxon Test" @default.
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- W2010143989 doi "https://doi.org/10.1002/bimj.4710330303" @default.
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