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- W2010152893 abstract "Over the last decade, epidermal growth factor (EGF) signaling has been used repeatedly as a testbed for pioneering computational systems biology. Recent breakthroughs in our molecular understanding of EGF signaling pose new challenges for mathematical modeling strategies. Three key areas emerge as particularly relevant: the pervasive importance of compartmentalization and endosomal trafficking; the complexity of signalosome complexes; and the regulatory influence of diffusion and spatiality. Each one of them demands a drastic change in current computational approaches. We discuss recent developments in the field that address these emerging aspects in a new generation of more realistic – and potential more useful – models of EGF signaling." @default.
- W2010152893 created "2016-06-24" @default.
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- W2010152893 date "2005-11-02" @default.
- W2010152893 modified "2023-10-13" @default.
- W2010152893 title "Current challenges in quantitative modeling of epidermal growth factor signaling" @default.
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- W2010152893 doi "https://doi.org/10.1016/j.febslet.2005.10.034" @default.
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