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• W2010163869 abstract "In order to maintain in vivo anti-tumor efficacy of antigen (Ag)-specific T cells in adoptive immunotherapy for a prolonged period, we constructed a fusion protein (OVA/IL-2) containing ovalbumin (OVA) as a model tumor Ag, co-valently linked to murine interleukin-2 (IL-2). The OVA/IL-2 protein produced in a baculovirus expression system displayed potent IL-2 bio-activity. Immunization with the OVA/IL-2 protein after adoptive transfer of OVA-specific T cells maintained the OVA-specific cytotoxicity and cell number of adoptively transferred T cells long term in vivo, while a simple mixture of recombinant OVA (rOVA) and rIL-2 did not. The response was dependent on the injection doses and times of the OVA/IL-2 protein. Furthermore, weekly re-stimulation of adoptively transferred OVA-specific T cells with the OVA/IL-2 protein cured 70% of tumor-bearing mice. In contrast, re-stimulation with a mixture of rOVA and rIL-2 could not significantly prolong the survival period of tumor-bearing mice. These studies suggest that the co-valent linkage between IL-2 and antigen confines the effect of IL-2 to antigen-specific T cells, leading to efficient maintenance of the anti-tumor activity of adoptively transferred T cells." @default.
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• W2010163869 date "1999-08-12" @default.
• W2010163869 modified "2023-09-26" @default.
• W2010163869 title "Antigen-specific cytotoxicity and cell number of adoptively transferred T cells are efficiently maintainedin vivo by re-stimulation with an antigen/interleukin-2 fusion protein" @default.
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• W2010163869 doi "https://doi.org/10.1002/(sici)1097-0215(19990812)82:4<569::aid-ijc16>3.0.co;2-m" @default.
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