FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010166345> ?p ?o ?g. }

• W2010166345 endingPage "656" @default.
• W2010166345 startingPage "650" @default.
• W2010166345 abstract "To determine whether histamine2-receptor antagonist (H2RA) dose modified for renal impairment affects gastrointestinal (GI) disease control.Concurrent medical record review.One hundred forty-six nursing facilities throughout the United States.Three hundred thirty-six patients aged 65 and older receiving H2RAs for GI disorders.H2RA dose modified for renal impairment or no dose change.Disease control (no H2RA dose increase for 6 months or longer, additional GI medication, hospitalizations, emergency room visits, and unscheduled physician visits for GI symptoms) was evaluated using chart review at 3, 6, 9, and 12 months in nursing home patients aged 65 and older with H2RA dose modified for decreased creatinine clearance (ClCr) according to manufacturer.Three hundred thirty-six patients, mean age +/- standard deviation 85.9 +/- 7.9, with mean ClCr of 33.6 +/- 10.4 mL/min, were recommended to receive lower H2RA doses based upon estimated renal function. Patients were analyzed in two groups: H2RA dose reduced (Group 1) and dose reduction not adopted or implemented (Group 2). There was no difference in baseline characteristics (age, weight, ClCr, or starting H2RA dose and indication) between the two groups. One hundred ninety-eight patients in Group 1 were taking 195.5 +/- 71.0 mg per day of nizatidine or equivalent, compared with 183.7 +/- 66.6 mg for 138 patients in Group 2. For patients with 90 days of follow-up, the mean H2RA dose in Group 1 was 100.2 +/- 44.3 mg, compared with 187.8 +/- 69.9 for Group 2 (P <.0001) The mean decrease in daily dose for Groups 1 and 2 after 365 days were 98.9 +/- 72.9 mg and 22.2 +/- 68.2 mg, respectively (P <.0001). Except for more physician visits in Group 2, disease control was similar for all groups. Major and minor GI bleeding events were similar across both groups and over time. The 12-month mortality rate was 12.1% and 21.7% for Groups 1 and 2, respectively. This difference was statistically significant (P =.02).The findings suggest that the dose of H2RAs may be decreased based upon renal function in frail elderly patients without compromising GI disease control." @default.
• W2010166345 created "2016-06-24" @default.
• W2010166345 creator A5000097835 @default.
• W2010166345 creator A5029701445 @default.
• W2010166345 creator A5031786981 @default.
• W2010166345 creator A5067710734 @default.
• W2010166345 creator A5069996216 @default.
• W2010166345 creator A5090645848 @default.
• W2010166345 date "2003-05-01" @default.
• W2010166345 modified "2023-09-26" @default.
• W2010166345 title "Gastrointestinal Disease Control After Histamine2-Receptor Antagonist Dose Modification for Renal Impairment in Frail Chronically Ill Elderly Patients" @default.
• W2010166345 cites W126052903 @default.
• W2010166345 cites W1967326205 @default.
• W2010166345 cites W1969842929 @default.
• W2010166345 cites W1987766910 @default.
• W2010166345 cites W1989183712 @default.
• W2010166345 cites W1990125864 @default.
• W2010166345 cites W1991630564 @default.
• W2010166345 cites W1995673197 @default.
• W2010166345 cites W2013981808 @default.
• W2010166345 cites W2019327551 @default.
• W2010166345 cites W2022607863 @default.
• W2010166345 cites W2027972598 @default.
• W2010166345 cites W2045999561 @default.
• W2010166345 cites W2061745965 @default.
• W2010166345 cites W2061755289 @default.
• W2010166345 cites W2063560184 @default.
• W2010166345 cites W2067978628 @default.
• W2010166345 cites W2075463212 @default.
• W2010166345 cites W2101887269 @default.
• W2010166345 cites W2140578325 @default.
• W2010166345 cites W2313046836 @default.
• W2010166345 cites W2955831827 @default.
• W2010166345 cites W4255312626 @default.
• W2010166345 cites W4300540465 @default.
• W2010166345 doi "https://doi.org/10.1034/j.1600-0579.2003.00209.x" @default.
• W2010166345 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12752840" @default.
• W2010166345 hasPublicationYear "2003" @default.
• W2010166345 type Work @default.
• W2010166345 sameAs 2010166345 @default.
• W2010166345 citedByCount "7" @default.
• W2010166345 countsByYear W20101663452012 @default.
• W2010166345 countsByYear W20101663452017 @default.
• W2010166345 countsByYear W20101663452018 @default.
• W2010166345 crossrefType "journal-article" @default.
• W2010166345 hasAuthorship W2010166345A5000097835 @default.
• W2010166345 hasAuthorship W2010166345A5029701445 @default.
• W2010166345 hasAuthorship W2010166345A5031786981 @default.
• W2010166345 hasAuthorship W2010166345A5067710734 @default.
• W2010166345 hasAuthorship W2010166345A5069996216 @default.
• W2010166345 hasAuthorship W2010166345A5090645848 @default.
• W2010166345 hasConcept C126322002 @default.
• W2010166345 hasConcept C141071460 @default.
• W2010166345 hasConcept C159641895 @default.
• W2010166345 hasConcept C170493617 @default.
• W2010166345 hasConcept C2776885963 @default.
• W2010166345 hasConcept C2778653478 @default.
• W2010166345 hasConcept C71924100 @default.
• W2010166345 hasConcept C90924648 @default.
• W2010166345 hasConceptScore W2010166345C126322002 @default.
• W2010166345 hasConceptScore W2010166345C141071460 @default.
• W2010166345 hasConceptScore W2010166345C159641895 @default.
• W2010166345 hasConceptScore W2010166345C170493617 @default.
• W2010166345 hasConceptScore W2010166345C2776885963 @default.
• W2010166345 hasConceptScore W2010166345C2778653478 @default.
• W2010166345 hasConceptScore W2010166345C71924100 @default.
• W2010166345 hasConceptScore W2010166345C90924648 @default.
• W2010166345 hasIssue "5" @default.
• W2010166345 hasLocation W20101663451 @default.
• W2010166345 hasLocation W20101663452 @default.
• W2010166345 hasOpenAccess W2010166345 @default.
• W2010166345 hasPrimaryLocation W20101663451 @default.
• W2010166345 hasRelatedWork W2002120878 @default.
• W2010166345 hasRelatedWork W2003938723 @default.
• W2010166345 hasRelatedWork W2047967234 @default.
• W2010166345 hasRelatedWork W2118496982 @default.
• W2010166345 hasRelatedWork W2364998975 @default.
• W2010166345 hasRelatedWork W2369162477 @default.
• W2010166345 hasRelatedWork W2439875401 @default.
• W2010166345 hasRelatedWork W4238867864 @default.
• W2010166345 hasRelatedWork W2519357708 @default.
• W2010166345 hasRelatedWork W2525756941 @default.
• W2010166345 hasVolume "51" @default.
• W2010166345 isParatext "false" @default.
• W2010166345 isRetracted "false" @default.
• W2010166345 magId "2010166345" @default.
• W2010166345 workType "article" @default.