FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010166612> ?p ?o ?g. }

• W2010166612 endingPage "237" @default.
• W2010166612 startingPage "231" @default.
• W2010166612 abstract "Estrogens have been shown to be protective agents against neurodegeneration and associated cognitive decline in aging females. However, clinical data have been equivocal as to the benefits to the brain and cognition of estrogen therapy in postmenopausal women. One factor that is proposed to be critical in determining the efficacy of hormone therapy is the timing of its initiation. The critical period or window of opportunity hypothesis proposes that following long-term ovarian hormone deprivation, the brain and cognition become insensitive to exogenously administered estrogens. In contrast, if estrogens are administered during a critical period near the time of cessation of ovarian function, they will exert beneficial effects. The focus of the current review is the examination of evidence from rodent models investigating the critical period hypothesis. A growing body of experimental data indicates that beneficial effects of 17β-estradiol (estradiol) on cognition and on cholinergic function and hippocampal plasticity, both of which have been linked to the ability of estradiol to exert beneficial effects on cognition, are attenuated if estradiol is administered following a period of long-term ovarian hormone deprivation. Further, emerging data implicate loss of estrogen receptor alpha (ERα) in the brain resulting from long-term hormone deprivation as a basis for the existence of the critical period. A unifying model is proposed by which the presence or absence of estrogens during a critical period following the cessation of ovarian function permanently alters the system resulting in decreased or increased risk, respectively, of neurodegeneration and cognitive decline." @default.
• W2010166612 created "2016-06-24" @default.
• W2010166612 creator A5068046669 @default.
• W2010166612 date "2013-02-01" @default.
• W2010166612 modified "2023-10-12" @default.
• W2010166612 title "Estrogens, estrogen receptors, and female cognitive aging: The impact of timing" @default.
• W2010166612 cites W1488634403 @default.
• W2010166612 cites W1837310873 @default.
• W2010166612 cites W1899274055 @default.
• W2010166612 cites W1970017598 @default.
• W2010166612 cites W1970227809 @default.
• W2010166612 cites W1977230392 @default.
• W2010166612 cites W1977598790 @default.
• W2010166612 cites W1983776621 @default.
• W2010166612 cites W1988633109 @default.
• W2010166612 cites W1992956438 @default.
• W2010166612 cites W1993176591 @default.
• W2010166612 cites W1999766015 @default.
• W2010166612 cites W1999771234 @default.
• W2010166612 cites W2001840421 @default.
• W2010166612 cites W2004411275 @default.
• W2010166612 cites W2005016581 @default.
• W2010166612 cites W2005415249 @default.
• W2010166612 cites W2006377495 @default.
• W2010166612 cites W2007151209 @default.
• W2010166612 cites W2009343153 @default.
• W2010166612 cites W2012094333 @default.
• W2010166612 cites W2013980291 @default.
• W2010166612 cites W2024630005 @default.
• W2010166612 cites W2029817026 @default.
• W2010166612 cites W2030997633 @default.
• W2010166612 cites W2034639126 @default.
• W2010166612 cites W2037611373 @default.
• W2010166612 cites W2039908660 @default.
• W2010166612 cites W2048182526 @default.
• W2010166612 cites W2049932034 @default.
• W2010166612 cites W2053673707 @default.
• W2010166612 cites W2054091180 @default.
• W2010166612 cites W2055456545 @default.
• W2010166612 cites W2056735634 @default.
• W2010166612 cites W2058183801 @default.
• W2010166612 cites W2060261367 @default.
• W2010166612 cites W2061754135 @default.
• W2010166612 cites W2063197495 @default.
• W2010166612 cites W2064016146 @default.
• W2010166612 cites W2065875615 @default.
• W2010166612 cites W2067872627 @default.
• W2010166612 cites W2067905106 @default.
• W2010166612 cites W2068492591 @default.
• W2010166612 cites W2070218253 @default.
• W2010166612 cites W2071350862 @default.
• W2010166612 cites W2072787342 @default.
• W2010166612 cites W2073102858 @default.
• W2010166612 cites W2073576669 @default.
• W2010166612 cites W2074585021 @default.
• W2010166612 cites W2083752668 @default.
• W2010166612 cites W2090058810 @default.
• W2010166612 cites W2092338494 @default.
• W2010166612 cites W2093676604 @default.
• W2010166612 cites W2097075649 @default.
• W2010166612 cites W2108630749 @default.
• W2010166612 cites W2110457784 @default.
• W2010166612 cites W2110550793 @default.
• W2010166612 cites W2110887671 @default.
• W2010166612 cites W2118733200 @default.
• W2010166612 cites W2119691301 @default.
• W2010166612 cites W2121403142 @default.
• W2010166612 cites W2123652060 @default.
• W2010166612 cites W2123816408 @default.
• W2010166612 cites W2131266318 @default.
• W2010166612 cites W2135910109 @default.
• W2010166612 cites W2136011008 @default.
• W2010166612 cites W2137482825 @default.
• W2010166612 cites W2143756844 @default.
• W2010166612 cites W2144657436 @default.
• W2010166612 cites W2148944193 @default.
• W2010166612 cites W2157544511 @default.
• W2010166612 cites W2161695527 @default.
• W2010166612 cites W2164589456 @default.
• W2010166612 cites W2169175207 @default.
• W2010166612 cites W2209257886 @default.
• W2010166612 cites W4293872195 @default.
• W2010166612 doi "https://doi.org/10.1016/j.yhbeh.2012.05.003" @default.
• W2010166612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22587940" @default.
• W2010166612 hasPublicationYear "2013" @default.
• W2010166612 type Work @default.
• W2010166612 sameAs 2010166612 @default.
• W2010166612 citedByCount "106" @default.
• W2010166612 countsByYear W20101666122012 @default.
• W2010166612 countsByYear W20101666122013 @default.
• W2010166612 countsByYear W20101666122014 @default.
• W2010166612 countsByYear W20101666122015 @default.
• W2010166612 countsByYear W20101666122016 @default.
• W2010166612 countsByYear W20101666122017 @default.
• W2010166612 countsByYear W20101666122018 @default.
• W2010166612 countsByYear W20101666122019 @default.
• W2010166612 countsByYear W20101666122020 @default.
• W2010166612 countsByYear W20101666122021 @default.

• next