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- W2010166807 abstract "Abstract Although 20,25-diazacholesterol (20,25-D) administration in rats causes myotonia, little is known of the effects of this drug on smooth muscle in this animal model of moytonic dystrophy. Female rats were treated weekly with 300 mg/kg 20,25-D and killed after periods as long as 144 days. Samples of aorta, portal vein, carotid artery, trachea, lower esophagus, ileal longitudinal muscle, and uterus were removed, extracted, and analyzed for sterols in a gas-liquid chromatograph. Massive replacement of cholesterol by desmosterol occurred in all these tissues within 3 to 8 weeks, together with decreases in total sterols; these changes were similar to those seen also in cardiac and skeletal muscle. Muscarinic receptor parameters were determined in ileal longitudinal muscle by assaying the specific binding of the muscarinic antagonist, [ 3 H]quinuclidinyl benzilate (QNB). After chronic 20,25-D treatment a small but statistically significant increase in the dissociation constant for QNB was found, suggesting that receptor conformation had been altered resulting in a decreased affinity for QNB. Receptor density, measured as picomoles receptor per milligram protein, was significantly increased by 20,25-D. These experiments established that 20,25-D causes desmosterol accumulation in smooth muscle at rates and magnitudes comparable to those seen in skeletal muscle, and suggest that modification of muscarinic receptors may be a contributing factor to any altered functional characteristics of smooth muscle in this animal model." @default.
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- W2010166807 title "Smooth muscle in an animal model of myotonic dystrophy" @default.
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- W2010166807 doi "https://doi.org/10.1016/0014-4886(78)90157-7" @default.
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