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- W2010168302 abstract "Transmissible spongiform encephalopathies display long incubation periods at the beginning of which the titer of infectious agents (prions) increases in peripheral lymphoid organs. This replication leads to a progressive invasion of the CNS. Follicular dendritic cells appear to support prion replication in lymphoid follicles. However, the subsequent steps of neuroinvasion remain obscure. CD11c(+) dendritic cells, an unrelated cell type, are candidate vectors for prion propagation. We found a high infectivity titer in splenic dendritic cells from prion-infected mice, suggesting that dendritic cells carry infection. To test this hypothesis, we injected RAG-1(0/0) mice intravenously with live spleen cell subsets from scrapie-infected donors. Injection of infected dendritic cells induced scrapie without accumulation of prions in the spleen. These results suggest that CD11c(+) dendritic cells can propagate prions from the periphery to the CNS in the absence of any additional lymphoid element." @default.
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- W2010168302 date "2001-09-01" @default.
- W2010168302 modified "2023-10-11" @default.
- W2010168302 title "Infected splenic dendritic cells are sufficient for prion transmission to the CNS in mouse scrapie" @default.
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- W2010168302 doi "https://doi.org/10.1172/jci13155" @default.
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