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• W2010170013 abstract "In our in vitro model, rasagiline a selective irreversible monoamine oxidase-B (MAO-B) inhibitor, protected nerve growth factor (NGF)-differentiated PC12 cells from cell death under oxygen and glucose deprivation (OGD). The severity of the OGD insult, as expressed by cell death, was time-dependent. Exposure of the cells to OGD for 3 hr followed by 18 hr of reoxygenation caused about 30–40% cell death. Under these conditions, the neuroprotective effect of rasagiline was dose-dependent: rasagiline reducing OGD-induced cell death by 68% and 80% at 100 nM and 1 μM, respectively. The neuroprotective effect of rasagiline was also observed when added after the OGD insult (55% reduction in cell death). Under rasagiline treatment, there was a lesser decrease in ATP content in cultures exposed to OGD compared with that in untreated cultures. OGD followed by reoxygenation resulted in a several fold increase in PGE2 release into the extracellular medium. Rasagiline (100 nM–1 μM) markedly inhibited OGD-induced PGE2 release. Clorgyline, a monoamine oxidase-A (MAO-A) inhibitor, did not protect NGF-differentiated PC12 cells against OGD-induced cell death. As NGF-differentiated PC12 cells contain exclusively MAO type A, these data suggest that the neuroprotective effect of rasagiline under OGD conditions is independent of MAO inhibition. J. Neurosci. Res. 58:456–463, 1999. © 1999 Wiley-Liss, Inc." @default.
• W2010170013 created "2016-06-24" @default.
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• W2010170013 date "1999-10-11" @default.
• W2010170013 modified "2023-10-01" @default.
• W2010170013 title "Rasagiline, a monoamine oxidase-B inhibitor, protects NGF-differentiated PC12 cells against oxygen-glucose deprivation" @default.
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• W2010170013 doi "https://doi.org/10.1002/(sici)1097-4547(19991101)58:3<456::aid-jnr12>3.0.co;2-s" @default.
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