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- W2010172191 abstract "We investigated the possible negative regulation of the cell cycle by protein kinase C (PKC) isoforms in synchronously grown BALB/MK-2 mouse keratinocytes, in which PKC isoforms were overexpressed by using the adenovirus vector Ax. Cells at the G1/S boundary of the cell cycle were the most sensitive to the inhibitory effect of 12-O-tetradecanoylphorbol-13-acetate (TPA), a PKC agonist, resulting in G1 arrest. TPA-induced inhibition of DNA synthesis was augmented by overexpression of the η and δ isoforms, but rescued by the dominant-negative and antisense η isoforms. In contrast, the α and ζ isoforms showed no effect on DNA synthesis with or without TPA treatment. Immunoblotting indicated cell cycle-dependent expression of the η isoform, being highest in cells at the G1/S boundary. The present study provides evidence that the η and δ isoforms of PKC are involved in negative regulation of cell cycle at the G1/S boundary in mouse keratinocytes." @default.
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- W2010172191 date "1998-11-01" @default.
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- W2010172191 title "Phorbol Ester-induced G1 Arrest in BALB/MK-2 Mouse Keratinocytes Is Mediated by δ and η Isoforms of Protein Kinase C" @default.
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- W2010172191 doi "https://doi.org/10.1111/j.1349-7006.1998.tb00507.x" @default.
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