Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010177488> ?p ?o ?g. }
- W2010177488 endingPage "180" @default.
- W2010177488 startingPage "163" @default.
- W2010177488 abstract "The aim was to optimize norfloxacin niosomes for enhanced antibacterial activity and reduced bacterial resistance.Pseudomonas aeruginosa, a biofilm forming bacterium, was used as the test organism. Different norfloxacin niosomes were evaluated in vitro and in vivo, respectively, for antibacterial activity compared with aqueous drug solution. The influence of norfloxacin niosomes on biofilm formation was investigated. The interaction of niosomes with bacterial cells was also monitored using the scanning electron microscopy (SEM).The efficacy of niosomes depended on their composition. Standard niosomes of Span 60 and cholesterol were similar to drug solution. Incorporation of Tween 80, oleic acid (OA), OA/propylene glycol or lecithin produced fluid niosomes which reduced the MIC and inhibited biofilm formation compared with drug solution. Incorporation of a positively charged agent into fluid niosomes enhanced the antibacterial activity and reduced biofilm formation significantly. SEM showed evidence of vesicle adsorption to the bacteria with possible adhesion or fusion with the cell membrane. The in vivo skin model confirmed the in vitro results with optimum niosomes being more efficient than drug solution.Niosomes are promising for enhanced antibacterial activity and reduced resistance to antibiotics. The later can be achieved by inhibition of biofilm formation." @default.
- W2010177488 created "2016-06-24" @default.
- W2010177488 creator A5015719140 @default.
- W2010177488 creator A5059412486 @default.
- W2010177488 creator A5067984438 @default.
- W2010177488 creator A5075223712 @default.
- W2010177488 creator A5087362532 @default.
- W2010177488 date "2014-08-18" @default.
- W2010177488 modified "2023-10-01" @default.
- W2010177488 title "Optimization of niosomes for enhanced antibacterial activity and reduced bacterial resistance:<i>in vitro</i>and<i>in vivo</i>evaluation" @default.
- W2010177488 cites W12119413 @default.
- W2010177488 cites W1526743142 @default.
- W2010177488 cites W1579604458 @default.
- W2010177488 cites W1601951089 @default.
- W2010177488 cites W1843008176 @default.
- W2010177488 cites W1967287759 @default.
- W2010177488 cites W1972723441 @default.
- W2010177488 cites W1972896384 @default.
- W2010177488 cites W1973628884 @default.
- W2010177488 cites W1973706034 @default.
- W2010177488 cites W1979848820 @default.
- W2010177488 cites W1981891468 @default.
- W2010177488 cites W1985581069 @default.
- W2010177488 cites W1990183004 @default.
- W2010177488 cites W1994799867 @default.
- W2010177488 cites W1999792163 @default.
- W2010177488 cites W2000653962 @default.
- W2010177488 cites W2000753279 @default.
- W2010177488 cites W2007331931 @default.
- W2010177488 cites W2010685611 @default.
- W2010177488 cites W2015178572 @default.
- W2010177488 cites W2017466143 @default.
- W2010177488 cites W2019878257 @default.
- W2010177488 cites W2028080874 @default.
- W2010177488 cites W2028861639 @default.
- W2010177488 cites W2034202443 @default.
- W2010177488 cites W2034792024 @default.
- W2010177488 cites W2036652890 @default.
- W2010177488 cites W2038225831 @default.
- W2010177488 cites W2038864652 @default.
- W2010177488 cites W2043346930 @default.
- W2010177488 cites W2044020341 @default.
- W2010177488 cites W2044303752 @default.
- W2010177488 cites W2046097911 @default.
- W2010177488 cites W2048627375 @default.
- W2010177488 cites W2052129346 @default.
- W2010177488 cites W2054017840 @default.
- W2010177488 cites W2055117699 @default.
- W2010177488 cites W2062374558 @default.
- W2010177488 cites W2064805272 @default.
- W2010177488 cites W2066172704 @default.
- W2010177488 cites W2070330380 @default.
- W2010177488 cites W2076233570 @default.
- W2010177488 cites W2076491038 @default.
- W2010177488 cites W2081534467 @default.
- W2010177488 cites W2089155556 @default.
- W2010177488 cites W2090651792 @default.
- W2010177488 cites W2094677265 @default.
- W2010177488 cites W2105095634 @default.
- W2010177488 cites W2107372863 @default.
- W2010177488 cites W2110802387 @default.
- W2010177488 cites W2111943190 @default.
- W2010177488 cites W2112487751 @default.
- W2010177488 cites W2134709133 @default.
- W2010177488 cites W2138718575 @default.
- W2010177488 cites W2139663729 @default.
- W2010177488 cites W2146136320 @default.
- W2010177488 cites W2147013877 @default.
- W2010177488 cites W2147043487 @default.
- W2010177488 cites W2148311328 @default.
- W2010177488 cites W2154016364 @default.
- W2010177488 cites W2157042087 @default.
- W2010177488 cites W2170882399 @default.
- W2010177488 cites W2342213528 @default.
- W2010177488 cites W4240020391 @default.
- W2010177488 doi "https://doi.org/10.1517/17425247.2014.942639" @default.
- W2010177488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25135453" @default.
- W2010177488 hasPublicationYear "2014" @default.
- W2010177488 type Work @default.
- W2010177488 sameAs 2010177488 @default.
- W2010177488 citedByCount "48" @default.
- W2010177488 countsByYear W20101774882015 @default.
- W2010177488 countsByYear W20101774882016 @default.
- W2010177488 countsByYear W20101774882017 @default.
- W2010177488 countsByYear W20101774882018 @default.
- W2010177488 countsByYear W20101774882019 @default.
- W2010177488 countsByYear W20101774882020 @default.
- W2010177488 countsByYear W20101774882021 @default.
- W2010177488 countsByYear W20101774882022 @default.
- W2010177488 countsByYear W20101774882023 @default.
- W2010177488 crossrefType "journal-article" @default.
- W2010177488 hasAuthorship W2010177488A5015719140 @default.
- W2010177488 hasAuthorship W2010177488A5059412486 @default.
- W2010177488 hasAuthorship W2010177488A5067984438 @default.
- W2010177488 hasAuthorship W2010177488A5075223712 @default.
- W2010177488 hasAuthorship W2010177488A5087362532 @default.
- W2010177488 hasConcept C130316041 @default.
- W2010177488 hasConcept C150903083 @default.