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- W2010179507 abstract "Three, 12- and 20-month-old C57BL6/J mice, reared in standard conditions or in enriched environments, were administered subcutaneously either scopolamine hydrobromide, 0.6 or 1.2 mg kg− 1, or physiological saline (control mice) 15 min before testing their abilities to find an invisible platform in a modified version of the Morris water maze, the starting point being kept unchanged throughout the experiment to allow the aged animals to solve the task. The results demonstrated that: 1) All control mice, whatever their age, were able to learn the platform location, but the number of trials needed to reach the learning criterion (3 consecutive trials in less than 8 s) increased with age; 2) All the scopolamine-treated mice, whatever their age, were also able to learn the platform location. However, compared to age-matched controls, the number of trials needed to reach the learning criterion was greater; 3) Rearing the animals in an enriched environment antagonized the effect of scopolamine, but only in the youngest (3 month-old) mice. All control and scopolamine-treated mice, whatever their age and their rearing environment, remembered, 7 days later, the platform location." @default.
- W2010179507 created "2016-06-24" @default.
- W2010179507 creator A5017366585 @default.
- W2010179507 creator A5035136561 @default.
- W2010179507 creator A5067388729 @default.
- W2010179507 date "2007-01-01" @default.
- W2010179507 modified "2023-09-25" @default.
- W2010179507 title "Cholinergic system, rearing environment and trajectory learning during aging in mice" @default.
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- W2010179507 doi "https://doi.org/10.1016/j.physbeh.2006.09.024" @default.
- W2010179507 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17074375" @default.
- W2010179507 hasPublicationYear "2007" @default.
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