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- W2010180222 abstract "Skin contributes to the first line of defense against foreign materials outside of our body. In inflammatory skin disease, the pathogenesis is due to an immune reaction in the keratinocytes, immune cells and soluble mediators. Spa therapy is widely used for the treatment of inflammatory skin disease but the mechanisms are only partly understood by immune regulation. Spa therapy or balneotherapy in dermatologic disease can affect the secretion of pro-inflammatory cytokines, IL-1alpha and tumor-necrosis factor (TNF) from keratinocytes and possibly affect T cell differentiation. In this study, we evaluated the effect of spa spring water from Yong-Goong-Oun-Chun on cells and investigated the skin immune reaction. The treatment of spa spring water from Yong-Goong-Oun-Chun decreased the expression of pro-inflammatory cytokines under TLR stimulation to HaCaT cells and APCs. In addition, spa spring water attenuated the differentiation process of subsets of CD4+ T cells, i.e., Th1, Th2 and Th17 cells. All these immune parameters can be used to evaluate the efficacy of spa spring water in Korea in terms of immune modulatory effect." @default.
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- W2010180222 title "Tonic, phasic and cortical arousal in Gilles de la Tourette's syndrome." @default.
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- W2010180222 doi "https://doi.org/10.1136/jnnp.48.6.535" @default.
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