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• W2010180596 endingPage "734" @default.
• W2010180596 startingPage "719" @default.
• W2010180596 abstract "Carbohydrate signatures on tumor cells have functional implications in tumor growth and metastasis and constitute valuable tools in cancer diagnosis and immunotherapy. Increasing data regarding the mechanisms by which they are recognized by the immune system are facilitating the design of more efficient immunotherapeutic protocols based on cancer-associated glycan structures. Recent molecular and proteomic studies revealed that carbohydrates are recognized, not only by B cells and antibodies, but also by cells from the innate arm of immunity, as well as by T cells, and are able to induce specific T-cell immunity and cytotoxicity. In this review, we discuss and update the different strategies targeting tumor-associated carbohydrate antigens that are being evaluated for antitumor immunotherapy, an approach that will be highly relevant, especially when combined with other strategies, in the future fight against cancer." @default.
• W2010180596 created "2016-06-24" @default.
• W2010180596 creator A5067174466 @default.
• W2010180596 creator A5090545095 @default.
• W2010180596 date "2012-07-01" @default.
• W2010180596 modified "2023-09-23" @default.
• W2010180596 title "The sweet side of tumor immunotherapy" @default.
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