Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010182521> ?p ?o ?g. }
- W2010182521 endingPage "e84671" @default.
- W2010182521 startingPage "e84671" @default.
- W2010182521 abstract "Diabetic retinopathy (DR) is the leading cause of blindness in working-age adults. Early stage DR involves inflammation, vascular leakage, apoptosis of vascular cells and neurodegeneration. In this study, we hypothesized that cells derived from the stromal fraction of adipose tissue (ASC) could therapeutically rescue early stage DR features. Streptozotocin (STZ) induced diabetic athymic nude rats received single intravitreal injection of human ASC into one eye and saline into the other eye. Two months post onset of diabetes, administration of ASC significantly improved b wave amplitude (as measured by electroretinogram) within 1-3 weeks of injection compared to saline treated diabetic eyes. Subsequently, retinal histopathological evaluation revealed a significant decrease in vascular leakage and apoptotic cells around the retinal vessels in the diabetic eyes that received ASC compared to the eyes that received saline injection. In addition, molecular analyses have shown down-regulation in inflammatory gene expression in diabetic retina that received ASC compared to eyes that received saline. Interestingly, ASC were found to be localized near retinal vessels at higher densities than seen in age matched non-diabetic retina that received ASC. In vitro, ASC displayed sustained proliferation and decreased apoptosis under hyperglycemic stress. In addition, ASC in co-culture with retinal endothelial cells enhance endothelial survival and collaborate to form vascular networks. Taken together, our findings suggest that ASC are able to rescue the neural retina from hyperglycemia-induced degeneration, resulting in importantly improved visual function. Our pre-clinical studies support the translational development of adipose stem cell-based therapy for DR to address both retinal capillary and neurodegeneration." @default.
- W2010182521 created "2016-06-24" @default.
- W2010182521 creator A5003935246 @default.
- W2010182521 creator A5031736885 @default.
- W2010182521 creator A5038049390 @default.
- W2010182521 creator A5038864277 @default.
- W2010182521 creator A5046104318 @default.
- W2010182521 creator A5047069519 @default.
- W2010182521 creator A5063131669 @default.
- W2010182521 creator A5078690525 @default.
- W2010182521 creator A5082755018 @default.
- W2010182521 creator A5090900363 @default.
- W2010182521 date "2014-01-09" @default.
- W2010182521 modified "2023-10-07" @default.
- W2010182521 title "Regenerative Therapeutic Potential of Adipose Stromal Cells in Early Stage Diabetic Retinopathy" @default.
- W2010182521 cites W1480061376 @default.
- W2010182521 cites W1605777639 @default.
- W2010182521 cites W1675723454 @default.
- W2010182521 cites W1965131222 @default.
- W2010182521 cites W1966433278 @default.
- W2010182521 cites W1969554973 @default.
- W2010182521 cites W1971881510 @default.
- W2010182521 cites W1980636357 @default.
- W2010182521 cites W1983444416 @default.
- W2010182521 cites W1992159395 @default.
- W2010182521 cites W1995830850 @default.
- W2010182521 cites W1996901522 @default.
- W2010182521 cites W2007057348 @default.
- W2010182521 cites W2009027924 @default.
- W2010182521 cites W2015436684 @default.
- W2010182521 cites W2018016372 @default.
- W2010182521 cites W2020690823 @default.
- W2010182521 cites W2021634519 @default.
- W2010182521 cites W2025213053 @default.
- W2010182521 cites W2026846810 @default.
- W2010182521 cites W2027111051 @default.
- W2010182521 cites W2027605832 @default.
- W2010182521 cites W2028702444 @default.
- W2010182521 cites W2037662471 @default.
- W2010182521 cites W2039092880 @default.
- W2010182521 cites W2039792549 @default.
- W2010182521 cites W2047502426 @default.
- W2010182521 cites W2048157928 @default.
- W2010182521 cites W2049655446 @default.
- W2010182521 cites W2050752490 @default.
- W2010182521 cites W2057530373 @default.
- W2010182521 cites W2059831241 @default.
- W2010182521 cites W2065937657 @default.
- W2010182521 cites W2069590633 @default.
- W2010182521 cites W2071019778 @default.
- W2010182521 cites W2073939513 @default.
- W2010182521 cites W2074832091 @default.
- W2010182521 cites W2076491580 @default.
- W2010182521 cites W2076792879 @default.
- W2010182521 cites W2080694397 @default.
- W2010182521 cites W2081939329 @default.
- W2010182521 cites W2083156208 @default.
- W2010182521 cites W2084949203 @default.
- W2010182521 cites W2089183158 @default.
- W2010182521 cites W2089851064 @default.
- W2010182521 cites W2092579092 @default.
- W2010182521 cites W2094960653 @default.
- W2010182521 cites W2095189946 @default.
- W2010182521 cites W2098701890 @default.
- W2010182521 cites W2107342323 @default.
- W2010182521 cites W2109879260 @default.
- W2010182521 cites W2114222046 @default.
- W2010182521 cites W2116500923 @default.
- W2010182521 cites W2122045163 @default.
- W2010182521 cites W2124521298 @default.
- W2010182521 cites W2132161893 @default.
- W2010182521 cites W2133234260 @default.
- W2010182521 cites W2137906256 @default.
- W2010182521 cites W2138811791 @default.
- W2010182521 cites W2138846538 @default.
- W2010182521 cites W2149528201 @default.
- W2010182521 cites W2151487984 @default.
- W2010182521 cites W2153983785 @default.
- W2010182521 cites W2155580843 @default.
- W2010182521 cites W2158404092 @default.
- W2010182521 cites W2163591961 @default.
- W2010182521 cites W2167747754 @default.
- W2010182521 cites W2170729810 @default.
- W2010182521 cites W2173497140 @default.
- W2010182521 cites W2320308628 @default.
- W2010182521 cites W2329865516 @default.
- W2010182521 cites W2769264260 @default.
- W2010182521 cites W4238498163 @default.
- W2010182521 cites W4253337782 @default.
- W2010182521 doi "https://doi.org/10.1371/journal.pone.0084671" @default.
- W2010182521 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3886987" @default.
- W2010182521 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24416262" @default.
- W2010182521 hasPublicationYear "2014" @default.
- W2010182521 type Work @default.
- W2010182521 sameAs 2010182521 @default.
- W2010182521 citedByCount "84" @default.
- W2010182521 countsByYear W20101825212014 @default.
- W2010182521 countsByYear W20101825212015 @default.