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- W2010182567 endingPage "454" @default.
- W2010182567 startingPage "443" @default.
- W2010182567 abstract "Molecular chaperones and their associated cofactors form a group of highly specialized proteins that orchestrate the folding and unfolding of other proteins and the assembly and disassembly of protein complexes. Chaperones are found in all cell types and organisms, and their activity must be tightly regulated to maintain normal cell function. Indeed, deregulation of protein folding and protein complex assembly is the cause of various human diseases. Here, we present the results of an extensive review of the literature revealing that the post-translational modification (PTM) of chaperones has been selected during evolution as an efficient mean to regulate the activity and specificity of these key proteins. Because the addition and reciprocal removal of chemical groups can be triggered very rapidly, this mechanism provides an efficient switch to precisely regulate the activity of chaperones on specific substrates. The large number of PTMs detected in chaperones suggests that a combinatory code is at play to regulate function, activity, localization, and substrate specificity for this group of biologically important proteins. This review surveys the core information currently available as a starting point toward the more ambitious endeavor of deciphering the chaperone code." @default.
- W2010182567 created "2016-06-24" @default.
- W2010182567 creator A5024724276 @default.
- W2010182567 creator A5089889248 @default.
- W2010182567 date "2013-05-01" @default.
- W2010182567 modified "2023-10-02" @default.
- W2010182567 title "Regulation of molecular chaperones through post-translational modifications: Decrypting the chaperone code" @default.
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