Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010183971> ?p ?o ?g. }
- W2010183971 endingPage "100" @default.
- W2010183971 startingPage "93" @default.
- W2010183971 abstract "Chemoprevention through dietary intervention is an emerging option to reduce colon cancer mortality. β-catenin plays an important role in the Wnt signaling cascade that is most commonly dysregulated in colorectal cancer. Our aim was to explore the modulatory effect of silibinin on β-catenin expression employing 1,2-dimethylhydrazine (DMH) induced colon cancer in male Wistar rats as an experimental model during the different stages of carcinogenesis. Colon tissues were analyzed for the expression of β-catenin, proliferating cell nuclear antigen (PCNA) and argyrophilic nucleolar organizer regions by using immunohistochemistry and silver staining. Immunoblotting was employed to study cyclin D1 expression. Glutathione (GSH) and glutathione related enzymes were assayed by spectrophotometric analysis. Silibinin inhibited DMH-induced colon cancer by decreasing tumor incidence and multiplicity. Silibinin supplementation to DMH-treated rats restored the levels of GSH-dependent enzymes and decreased the levels of β-catenin, PCNA, argyrophilic nucleolar organizer regions and cyclin D1. Mechanistically silibinin inhibits DMH-induced colon carcinogenesis by modulating the Wnt/β-catenin pathway and glutathione redox system. Since colon cancer is highly sensitive to dietary intervention adults who may have preneoplastic lesions in their colon may be benefited by silibinin." @default.
- W2010183971 created "2016-06-24" @default.
- W2010183971 creator A5019633973 @default.
- W2010183971 creator A5036175177 @default.
- W2010183971 creator A5040169898 @default.
- W2010183971 creator A5044097220 @default.
- W2010183971 creator A5058839066 @default.
- W2010183971 creator A5063801470 @default.
- W2010183971 date "2010-09-01" @default.
- W2010183971 modified "2023-09-27" @default.
- W2010183971 title "Oral supplementation of silibinin prevents colon carcinogenesis in a long term preclinical model" @default.
- W2010183971 cites W1496143836 @default.
- W2010183971 cites W183984069 @default.
- W2010183971 cites W185117244 @default.
- W2010183971 cites W1967211691 @default.
- W2010183971 cites W1968218903 @default.
- W2010183971 cites W1970295158 @default.
- W2010183971 cites W1975232859 @default.
- W2010183971 cites W1981049076 @default.
- W2010183971 cites W1986093151 @default.
- W2010183971 cites W1989815639 @default.
- W2010183971 cites W1990669165 @default.
- W2010183971 cites W1991109718 @default.
- W2010183971 cites W2000782756 @default.
- W2010183971 cites W2001943317 @default.
- W2010183971 cites W2005508694 @default.
- W2010183971 cites W2009857926 @default.
- W2010183971 cites W2021133687 @default.
- W2010183971 cites W2024184602 @default.
- W2010183971 cites W2033295911 @default.
- W2010183971 cites W2033585269 @default.
- W2010183971 cites W2039685885 @default.
- W2010183971 cites W2040585298 @default.
- W2010183971 cites W2043600259 @default.
- W2010183971 cites W2052690509 @default.
- W2010183971 cites W2063108011 @default.
- W2010183971 cites W2065906773 @default.
- W2010183971 cites W2066434912 @default.
- W2010183971 cites W2072573412 @default.
- W2010183971 cites W2076785040 @default.
- W2010183971 cites W2080372560 @default.
- W2010183971 cites W2088220740 @default.
- W2010183971 cites W2089071918 @default.
- W2010183971 cites W2093263809 @default.
- W2010183971 cites W2094546720 @default.
- W2010183971 cites W2101108802 @default.
- W2010183971 cites W2105080125 @default.
- W2010183971 cites W2123947468 @default.
- W2010183971 cites W2125652675 @default.
- W2010183971 cites W2133699432 @default.
- W2010183971 cites W2135469933 @default.
- W2010183971 cites W2142779171 @default.
- W2010183971 cites W2165535625 @default.
- W2010183971 cites W4238448376 @default.
- W2010183971 doi "https://doi.org/10.1016/j.ejphar.2010.05.060" @default.
- W2010183971 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20537993" @default.
- W2010183971 hasPublicationYear "2010" @default.
- W2010183971 type Work @default.
- W2010183971 sameAs 2010183971 @default.
- W2010183971 citedByCount "35" @default.
- W2010183971 countsByYear W20101839712012 @default.
- W2010183971 countsByYear W20101839712013 @default.
- W2010183971 countsByYear W20101839712014 @default.
- W2010183971 countsByYear W20101839712015 @default.
- W2010183971 countsByYear W20101839712016 @default.
- W2010183971 countsByYear W20101839712017 @default.
- W2010183971 countsByYear W20101839712019 @default.
- W2010183971 countsByYear W20101839712020 @default.
- W2010183971 countsByYear W20101839712021 @default.
- W2010183971 countsByYear W20101839712022 @default.
- W2010183971 countsByYear W20101839712023 @default.
- W2010183971 crossrefType "journal-article" @default.
- W2010183971 hasAuthorship W2010183971A5019633973 @default.
- W2010183971 hasAuthorship W2010183971A5036175177 @default.
- W2010183971 hasAuthorship W2010183971A5040169898 @default.
- W2010183971 hasAuthorship W2010183971A5044097220 @default.
- W2010183971 hasAuthorship W2010183971A5058839066 @default.
- W2010183971 hasAuthorship W2010183971A5063801470 @default.
- W2010183971 hasConcept C121608353 @default.
- W2010183971 hasConcept C126322002 @default.
- W2010183971 hasConcept C137620995 @default.
- W2010183971 hasConcept C185592680 @default.
- W2010183971 hasConcept C199835354 @default.
- W2010183971 hasConcept C204232928 @default.
- W2010183971 hasConcept C2777130413 @default.
- W2010183971 hasConcept C29537977 @default.
- W2010183971 hasConcept C34688535 @default.
- W2010183971 hasConcept C502942594 @default.
- W2010183971 hasConcept C526805850 @default.
- W2010183971 hasConcept C55493867 @default.
- W2010183971 hasConcept C555283112 @default.
- W2010183971 hasConcept C62478195 @default.
- W2010183971 hasConcept C71924100 @default.
- W2010183971 hasConcept C86803240 @default.
- W2010183971 hasConceptScore W2010183971C121608353 @default.
- W2010183971 hasConceptScore W2010183971C126322002 @default.
- W2010183971 hasConceptScore W2010183971C137620995 @default.
- W2010183971 hasConceptScore W2010183971C185592680 @default.