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• W2010186735 abstract "Dopaminergic neurotoxicities of 6-hydroxydopamine (6-OHDA) and the lipopolysaccharide (LPS) were compared in rat mesencephalic cultures plated on poly-l-lysine or on glial monolayers. In the neuron-enriched cultures plated on polylysine, 6-OHDA killed 89% of the tyrosine hydroxylase (TH)-immunopositive neurons, but LPS was not neurotoxic. Conversely, in mixed neuron/glial cultures, 6-OHDA killed only 27% of the TH-immunopositive neurons while LPS killed 70%. The mixed neuronal/glial mesencephalic culture offers a better in vitro model for studying possible mechanisms involved in Parkinson's disease." @default.
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• W2010186735 date "1995-12-01" @default.
• W2010186735 modified "2023-10-18" @default.
• W2010186735 title "Glia-dependent neurotoxicity and neuroprotection in mesencephalic cultures" @default.
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• W2010186735 doi "https://doi.org/10.1016/0006-8993(95)01189-7" @default.
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