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• W2010188573 abstract "Nitric oxide (NO) and tumor necrosis factor-alpha (TNF-alpha) have been suggested to play an important role in endotoxin-mediated shock and inflammation. In this study, we investigated the effect of aqueous extract of Dichroa febrifuga Lour. (Saxifragaceae) roots, a traditional antimalarial drug, on the production of NO and TNF-alpha. The aqueous extract of D. febrifuga roots (AEDF) inhibited the secretion of NO and TNF-alpha in lipopolysaccharide (LPS) and/or interferon-gamma (IFN-gamma)-stimulated mouse peritoneal macrophages, without affecting cell viability. The protein level of inducible nitric oxide synthase (iNOS) in peritoneal macrophages was also decreased by AEDF. In addition, the serum level of NO was reduced by i.p. administration of AEDF. These results suggest that AEDF suppresses the endotoxin-induced inflammatory responses through inhibiting the production of NO and TNF-alpha, and could be used as an anti-inflammatory drug." @default.
• W2010188573 created "2016-06-24" @default.
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• W2010188573 date "2000-01-01" @default.
• W2010188573 modified "2023-10-14" @default.
• W2010188573 title "The production of nitric oxide and TNF-α in peritoneal macrophages is inhibited by Dichroa febrifuga Lour" @default.
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• W2010188573 doi "https://doi.org/10.1016/s0378-8741(99)00143-9" @default.
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