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- W2010191696 abstract "In a placebo-controlled, randomized, double-blind study the efficacy of a Vitex agnus castus extract-containing solution* (VACS) was investigated in patients suffering from cyclical mastalgia. Patients had mastalgia on at least 5 days in the pre-treatment cycle. During this cycle and during treatment (3 cycles; 2 × 30 drops/day), the intensity of mastalgia was recorded once per cycle using a visual analogue scale (VAS).After one/two treatment cycles, the mean decrease in pain intensity (mm, VAS) was 21.4 mm /33.7 mm in women taking VACS (n= 48) and 10.6 mm/20.3 mm with placebo (n=49). The differences of the VAS-values for VACS were significantly greater than those with placebo (p= 0.018;p= 0.006). After three cycles, the mean VAS-score reduction for women taking VACS was 34.3 mm, a reduction of ‘borderline significance’ (p= 0.064) on statistical testing compared with placebo (25.7 mm). There was no difference in the frequency of adverse events between both groups (VACS:n = 5; placebo: n= 4). VACS appears effective and was well tolerated and further evaluation of this agent in the treatment of cyclical mastalgia is warranted." @default.
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- W2010191696 date "2011-08-01" @default.
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- W2010191696 title "Comparison of surgical and medical treatment methods for women with recurrent miscarriages" @default.
- W2010191696 doi "https://doi.org/10.1016/j.jri.2011.06.089" @default.
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