FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010192504> ?p ?o ?g. }

• W2010192504 endingPage "809" @default.
• W2010192504 startingPage "799" @default.
• W2010192504 abstract "Abstract Adaptive responses to low oxygen (O2) tension (hypoxia) are mediated by the heterodimeric transcription factor hypoxia inducible factor (HIF). When stabilized by hypoxia, bHLH-PAS α- and β- (HIF-1β or ARNT) HIF complex regulate the expression of multiple genes, including vascular endothelial growth factor (VEGF). To investigate the mechanism(s) through which hypoxia contributes to blood vessel development, we used embryonic stem cell (ESC) differentiation cultures that develop into embryoid bodies (EBs) mimicking early embryonic development. Significantly, low O2 levels promote vascular development and maturation in wild-type (WT) ESC cultures measured by an increase in the numbers of CD31+ endothelial cells (ECs) and sprouting angiogenic EBs, but refractory in Arnt−/− and Vegf−/− ESC cultures. Thus, we propose that hypoxia promotes the production of ECs and contributes to the development and maturation of vessels. Our findings further demonstrate that hypoxia alters the temporal expression of VEGF receptors Flk-1 (VEGFR-2) and the membrane and soluble forms of the antagonistic receptor Flt-1 (VEGFR-1). Moreover, these receptors are distinctly expressed in differentiating Arnt−/− and Vegf−/− EBs. These results support existing models in which VEGF signaling is tightly regulated during specific biologic events, but also provide important novel evidence that, in response to physiologic hypoxia, HIF mediates a distinct stoichiometric pattern of VEGF receptors throughout EB differentiation analogous to the formation of vascular networks during embryogenesis." @default.
• W2010192504 created "2016-06-24" @default.
• W2010192504 creator A5040520126 @default.
• W2010192504 creator A5071079343 @default.
• W2010192504 creator A5084021698 @default.
• W2010192504 creator A5086302566 @default.
• W2010192504 date "2010-02-04" @default.
• W2010192504 modified "2023-10-03" @default.
• W2010192504 title "Hypoxia Influences the Vascular Expansion and Differentiation of Embryonic Stem Cell Cultures Through the Temporal Expression of Vascular Endothelial Growth Factor Receptors in an ARNT-Dependent Manner" @default.
• W2010192504 cites W1576487484 @default.
• W2010192504 cites W1581761562 @default.
• W2010192504 cites W1679229092 @default.
• W2010192504 cites W1972320565 @default.
• W2010192504 cites W1984604224 @default.
• W2010192504 cites W1986538872 @default.
• W2010192504 cites W1988155075 @default.
• W2010192504 cites W2003468428 @default.
• W2010192504 cites W2005277043 @default.
• W2010192504 cites W2005577087 @default.
• W2010192504 cites W2011995063 @default.
• W2010192504 cites W2014077602 @default.
• W2010192504 cites W2019165748 @default.
• W2010192504 cites W2025265682 @default.
• W2010192504 cites W2025665677 @default.
• W2010192504 cites W2033995616 @default.
• W2010192504 cites W2036326354 @default.
• W2010192504 cites W2039409357 @default.
• W2010192504 cites W2045247659 @default.
• W2010192504 cites W2050637668 @default.
• W2010192504 cites W2052238247 @default.
• W2010192504 cites W2055849146 @default.
• W2010192504 cites W2067295745 @default.
• W2010192504 cites W2070081704 @default.
• W2010192504 cites W2073131598 @default.
• W2010192504 cites W2073903637 @default.
• W2010192504 cites W2082481083 @default.
• W2010192504 cites W2100152476 @default.
• W2010192504 cites W2100203743 @default.
• W2010192504 cites W2110753523 @default.
• W2010192504 cites W2112832471 @default.
• W2010192504 cites W2117779825 @default.
• W2010192504 cites W2119607030 @default.
• W2010192504 cites W2122978965 @default.
• W2010192504 cites W2125765532 @default.
• W2010192504 cites W2127432537 @default.
• W2010192504 cites W2127878160 @default.
• W2010192504 cites W2128446133 @default.
• W2010192504 cites W2136023563 @default.
• W2010192504 cites W2171715330 @default.
• W2010192504 cites W4232309949 @default.
• W2010192504 cites W4376595584 @default.
• W2010192504 doi "https://doi.org/10.1002/stem.316" @default.
• W2010192504 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2989499" @default.
• W2010192504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20135683" @default.
• W2010192504 hasPublicationYear "2010" @default.
• W2010192504 type Work @default.
• W2010192504 sameAs 2010192504 @default.
• W2010192504 citedByCount "44" @default.
• W2010192504 countsByYear W20101925042012 @default.
• W2010192504 countsByYear W20101925042013 @default.
• W2010192504 countsByYear W20101925042014 @default.
• W2010192504 countsByYear W20101925042016 @default.
• W2010192504 countsByYear W20101925042018 @default.
• W2010192504 countsByYear W20101925042019 @default.
• W2010192504 countsByYear W20101925042020 @default.
• W2010192504 countsByYear W20101925042021 @default.
• W2010192504 countsByYear W20101925042022 @default.
• W2010192504 crossrefType "journal-article" @default.
• W2010192504 hasAuthorship W2010192504A5040520126 @default.
• W2010192504 hasAuthorship W2010192504A5071079343 @default.
• W2010192504 hasAuthorship W2010192504A5084021698 @default.
• W2010192504 hasAuthorship W2010192504A5086302566 @default.
• W2010192504 hasBestOaLocation W20101925042 @default.
• W2010192504 hasConcept C104317684 @default.
• W2010192504 hasConcept C143948831 @default.
• W2010192504 hasConcept C145103041 @default.
• W2010192504 hasConcept C146285616 @default.
• W2010192504 hasConcept C160450060 @default.
• W2010192504 hasConcept C167734588 @default.
• W2010192504 hasConcept C170493617 @default.
• W2010192504 hasConcept C178790620 @default.
• W2010192504 hasConcept C185592680 @default.
• W2010192504 hasConcept C20875687 @default.
• W2010192504 hasConcept C2777025900 @default.
• W2010192504 hasConcept C2778271429 @default.
• W2010192504 hasConcept C2778939058 @default.
• W2010192504 hasConcept C2780394083 @default.
• W2010192504 hasConcept C2910429298 @default.
• W2010192504 hasConcept C33594762 @default.
• W2010192504 hasConcept C45815257 @default.
• W2010192504 hasConcept C502942594 @default.
• W2010192504 hasConcept C540031477 @default.
• W2010192504 hasConcept C54355233 @default.
• W2010192504 hasConcept C7836513 @default.
• W2010192504 hasConcept C86339819 @default.
• W2010192504 hasConcept C86803240 @default.
• W2010192504 hasConcept C95444343 @default.
• W2010192504 hasConceptScore W2010192504C104317684 @default.

• next