FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010192972> ?p ?o ?g. }

• W2010192972 endingPage "1848" @default.
• W2010192972 startingPage "1843" @default.
• W2010192972 abstract "Objectives . A double-blind randomised trial was designed to determine the efficacy of intravenous and oral disopyramide phosphate in preventing neurally syncope induced by a head-up tilt test. Background . Neurally mediated syncope is a frequent cause of syncope and may be induced by head-up tilt, testing. Recent uncontrolled trials have suggested that disopyramide may be an effective therapy in patients with neurally mediated syncope. Methods . Twenty-two consecutive patients with recurrent neurally mediated syncope and two or successive positive head-up tilt test responses were randomly allocated to receive either intravenous disopyramide or placebo. Head-up tilt testing at 60 ° was performed for 15 min. If presyncope or syncope was not provoked, isoproterenol infusion was started at a rate of 1 μg/min and the rate gradually increased until a 25% increase in heart rate was achieved. Eleven patients were subsequently randomised in crossover fashion to receive oral disepyramide (800 mg/day) or placebo during 1 week. The primary end point was prevention of syncope or presyncope provoked by head-up tilt testing. Results . Head-up tilt test results were positive for syncope in 12 (75%) of 16 patients receiving intravenous placebo and in 12 (60%) of 20 patients receiving disopyramide (p = 0.55 Fisher exact test, 95% confidence interval [CI] −14% to 40%). In the intravenous phase, complete crossover was achieved in 15 patients. Head-up tilt test results during this were positive in 13 patients (87%) receiving placebo and in 12 patients (80%) receiving disopyramide (p = 0.50 Fisher exact test, 95% CI −19% to 32%) and were positive in all patients receiving their initially randomized drug or placebo. In the oral phase, head-up tilt results were positive in only two patients (18%) assigned to placebo and in three patients (27%) receiving disopyramide (p = 0.54 Fisher exact test, 95% CI −42% to 24%). A mean follow-up time of 29 ± 8 months was obtained in 21 of the 22 patients. Syncope recurred in 3 (27%) of the 11 patients receiving disopyramide and 3 (30%) of the 10 patients not treated pharmacologically (p > 0.05). Conclusions . Intravenous disopyramide was ineffective for the prevention of neurally mediated syncope provoked by head-up tilt testing. No significant effect was observed after oral therapy with disopyramide. There was a striking decrease in the incidence of positive tilt test results over time regardless of intervention, thus discouraging the use of head-up tilt as the single method of assessing therapeutic efficacy. Recurrence of syncope after the investigative protocol was infrequent over long-term follow-up regardless of treatment group." @default.
• W2010192972 created "2016-06-24" @default.
• W2010192972 creator A5013471410 @default.
• W2010192972 creator A5042749455 @default.
• W2010192972 creator A5061020443 @default.
• W2010192972 creator A5088254871 @default.
• W2010192972 date "1993-12-01" @default.
• W2010192972 modified "2023-10-04" @default.
• W2010192972 title "A placebo-controlled trial of intravenous and oral disopyramide for prevention of neurally mediated syncope induced by heap-up tilt" @default.
• W2010192972 cites W1565165145 @default.
• W2010192972 cites W1959237090 @default.
• W2010192972 cites W1967300763 @default.
• W2010192972 cites W1968436504 @default.
• W2010192972 cites W1985102309 @default.
• W2010192972 cites W1988058143 @default.
• W2010192972 cites W1990684611 @default.
• W2010192972 cites W1998260257 @default.
• W2010192972 cites W1999962309 @default.
• W2010192972 cites W2008170185 @default.
• W2010192972 cites W2019569528 @default.
• W2010192972 cites W2020762911 @default.
• W2010192972 cites W2026511161 @default.
• W2010192972 cites W2026721906 @default.
• W2010192972 cites W2031597144 @default.
• W2010192972 cites W2054298073 @default.
• W2010192972 cites W2055150565 @default.
• W2010192972 cites W2056019754 @default.
• W2010192972 cites W2058565111 @default.
• W2010192972 cites W2072510862 @default.
• W2010192972 cites W2075840662 @default.
• W2010192972 cites W2075977613 @default.
• W2010192972 cites W2076772189 @default.
• W2010192972 cites W2083909219 @default.
• W2010192972 cites W2086345063 @default.
• W2010192972 cites W2126339544 @default.
• W2010192972 cites W2145980947 @default.
• W2010192972 cites W2147167561 @default.
• W2010192972 cites W2321726344 @default.
• W2010192972 doi "https://doi.org/10.1016/0735-1097(93)90767-u" @default.
• W2010192972 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8245337" @default.
• W2010192972 hasPublicationYear "1993" @default.
• W2010192972 type Work @default.
• W2010192972 sameAs 2010192972 @default.
• W2010192972 citedByCount "191" @default.
• W2010192972 countsByYear W20101929722012 @default.
• W2010192972 countsByYear W20101929722013 @default.
• W2010192972 countsByYear W20101929722014 @default.
• W2010192972 countsByYear W20101929722015 @default.
• W2010192972 countsByYear W20101929722016 @default.
• W2010192972 countsByYear W20101929722017 @default.
• W2010192972 countsByYear W20101929722019 @default.
• W2010192972 countsByYear W20101929722020 @default.
• W2010192972 countsByYear W20101929722021 @default.
• W2010192972 countsByYear W20101929722022 @default.
• W2010192972 countsByYear W20101929722023 @default.
• W2010192972 crossrefType "journal-article" @default.
• W2010192972 hasAuthorship W2010192972A5013471410 @default.
• W2010192972 hasAuthorship W2010192972A5042749455 @default.
• W2010192972 hasAuthorship W2010192972A5061020443 @default.
• W2010192972 hasAuthorship W2010192972A5088254871 @default.
• W2010192972 hasConcept C126322002 @default.
• W2010192972 hasConcept C142724271 @default.
• W2010192972 hasConcept C164705383 @default.
• W2010192972 hasConcept C204787440 @default.
• W2010192972 hasConcept C27081682 @default.
• W2010192972 hasConcept C2776146683 @default.
• W2010192972 hasConcept C2777953023 @default.
• W2010192972 hasConcept C2778122182 @default.
• W2010192972 hasConcept C2779831137 @default.
• W2010192972 hasConcept C2780703726 @default.
• W2010192972 hasConcept C2781312747 @default.
• W2010192972 hasConcept C42219234 @default.
• W2010192972 hasConcept C44249647 @default.
• W2010192972 hasConcept C71924100 @default.
• W2010192972 hasConcept C84393581 @default.
• W2010192972 hasConcept C87813604 @default.
• W2010192972 hasConceptScore W2010192972C126322002 @default.
• W2010192972 hasConceptScore W2010192972C142724271 @default.
• W2010192972 hasConceptScore W2010192972C164705383 @default.
• W2010192972 hasConceptScore W2010192972C204787440 @default.
• W2010192972 hasConceptScore W2010192972C27081682 @default.
• W2010192972 hasConceptScore W2010192972C2776146683 @default.
• W2010192972 hasConceptScore W2010192972C2777953023 @default.
• W2010192972 hasConceptScore W2010192972C2778122182 @default.
• W2010192972 hasConceptScore W2010192972C2779831137 @default.
• W2010192972 hasConceptScore W2010192972C2780703726 @default.
• W2010192972 hasConceptScore W2010192972C2781312747 @default.
• W2010192972 hasConceptScore W2010192972C42219234 @default.
• W2010192972 hasConceptScore W2010192972C44249647 @default.
• W2010192972 hasConceptScore W2010192972C71924100 @default.
• W2010192972 hasConceptScore W2010192972C84393581 @default.
• W2010192972 hasConceptScore W2010192972C87813604 @default.
• W2010192972 hasIssue "7" @default.
• W2010192972 hasLocation W20101929721 @default.
• W2010192972 hasLocation W20101929722 @default.
• W2010192972 hasOpenAccess W2010192972 @default.
• W2010192972 hasPrimaryLocation W20101929721 @default.
• W2010192972 hasRelatedWork W1502460338 @default.

• next