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- W2010193886 abstract "Although sickle cell disease (SCD) has a variable clinical course, many patients develop end-organ complications that are associated with significant morbidity and early mortality. Myeloablative allogeneic HSCT (allo-HSCT) is curative but has been historically performed only in children younger than 16 years of age. Modest modifications in the conditioning regimen and supportive care have improved outcome such that the majority of children with a suitable HLA-matched sibling donor can expect a cure from this approach. However, adult patients have been excluded from myeloablative allo-HSCT because of anticipated excess toxicity resulting from accumulated disease burden. Efforts to use nonmyeloablative transplantation strategies in adults logically followed but were initially met with largely disappointing results. Recent results, however, indicate that nonmyeloablative allo-HSCT in adult patients with SCD allows for stable mixed hematopoietic chimerism with associated full-donor erythroid engraftment and normalization of blood counts, and persistence in some without continued immunosuppression suggests immunologic tolerance. The attainment of tolerance should allow extension of these potentially curative approaches to alternative donor sources. Efforts to build on these experiences should increase the use of allo-HSCT in patients with SCD while minimizing morbidity and mortality." @default.
- W2010193886 created "2016-06-24" @default.
- W2010193886 creator A5001134935 @default.
- W2010193886 creator A5063279617 @default.
- W2010193886 creator A5087536541 @default.
- W2010193886 date "2011-08-04" @default.
- W2010193886 modified "2023-10-14" @default.
- W2010193886 title "Allogeneic hematopoietic stem cell transplantation for sickle cell disease: the time is now" @default.
- W2010193886 cites W1547120987 @default.
- W2010193886 cites W1550825447 @default.
- W2010193886 cites W1552494879 @default.
- W2010193886 cites W1616716935 @default.
- W2010193886 cites W1719867626 @default.
- W2010193886 cites W1964441462 @default.
- W2010193886 cites W1966530560 @default.
- W2010193886 cites W1969849446 @default.
- W2010193886 cites W1978242664 @default.
- W2010193886 cites W1979483940 @default.
- W2010193886 cites W1989516517 @default.
- W2010193886 cites W1991680384 @default.
- W2010193886 cites W1997170085 @default.
- W2010193886 cites W1998647856 @default.
- W2010193886 cites W2009398387 @default.
- W2010193886 cites W2009680674 @default.
- W2010193886 cites W2011508091 @default.
- W2010193886 cites W2011543427 @default.
- W2010193886 cites W2016597477 @default.
- W2010193886 cites W2017875875 @default.
- W2010193886 cites W2023031066 @default.
- W2010193886 cites W2024725095 @default.
- W2010193886 cites W2024999114 @default.
- W2010193886 cites W2025690693 @default.
- W2010193886 cites W2032459177 @default.
- W2010193886 cites W2032487385 @default.
- W2010193886 cites W2032566171 @default.
- W2010193886 cites W2032742509 @default.
- W2010193886 cites W2037256495 @default.
- W2010193886 cites W2037731315 @default.
- W2010193886 cites W2038025545 @default.
- W2010193886 cites W2039334806 @default.
- W2010193886 cites W2042416746 @default.
- W2010193886 cites W2042559457 @default.
- W2010193886 cites W2042997234 @default.
- W2010193886 cites W2045234878 @default.
- W2010193886 cites W2045690184 @default.
- W2010193886 cites W2048215072 @default.
- W2010193886 cites W2049224577 @default.
- W2010193886 cites W2049661833 @default.
- W2010193886 cites W2050007196 @default.
- W2010193886 cites W2055232789 @default.
- W2010193886 cites W2060076356 @default.
- W2010193886 cites W2060136712 @default.
- W2010193886 cites W2060745772 @default.
- W2010193886 cites W2063625476 @default.
- W2010193886 cites W2065697585 @default.
- W2010193886 cites W2070223505 @default.
- W2010193886 cites W2076789303 @default.
- W2010193886 cites W2076949422 @default.
- W2010193886 cites W2077174747 @default.
- W2010193886 cites W2079110478 @default.
- W2010193886 cites W2086900076 @default.
- W2010193886 cites W2092627970 @default.
- W2010193886 cites W2093626328 @default.
- W2010193886 cites W2093750771 @default.
- W2010193886 cites W2104662701 @default.
- W2010193886 cites W2107278930 @default.
- W2010193886 cites W2109135798 @default.
- W2010193886 cites W2109537389 @default.
- W2010193886 cites W2111444354 @default.
- W2010193886 cites W2119324304 @default.
- W2010193886 cites W2120119492 @default.
- W2010193886 cites W2121444412 @default.
- W2010193886 cites W2127432854 @default.
- W2010193886 cites W2133971325 @default.
- W2010193886 cites W2134623864 @default.
- W2010193886 cites W2135689851 @default.
- W2010193886 cites W2137879252 @default.
- W2010193886 cites W2139028184 @default.
- W2010193886 cites W2143729842 @default.
- W2010193886 cites W2144729122 @default.
- W2010193886 cites W2148547093 @default.
- W2010193886 cites W2149010831 @default.
- W2010193886 cites W2151452421 @default.
- W2010193886 cites W2152197116 @default.
- W2010193886 cites W2152954197 @default.
- W2010193886 cites W2155462891 @default.
- W2010193886 cites W2170851632 @default.
- W2010193886 cites W2171960908 @default.
- W2010193886 cites W2313541759 @default.
- W2010193886 cites W2323938126 @default.
- W2010193886 cites W2324143840 @default.
- W2010193886 cites W2335701371 @default.
- W2010193886 cites W2585300045 @default.
- W2010193886 cites W2612358036 @default.
- W2010193886 doi "https://doi.org/10.1182/blood-2011-01-332510" @default.
- W2010193886 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3152491" @default.
- W2010193886 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21628400" @default.
- W2010193886 hasPublicationYear "2011" @default.