Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010201220> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2010201220 endingPage "1607" @default.
- W2010201220 startingPage "1600" @default.
- W2010201220 abstract "The myc family of transcriptional regulators carries out critical roles in the control of cellular proliferation, differentiation, apoptosis, and tumorigenesis. The B-myc gene is a recently identified myc family member that has not been well characterized. Previously, we have shown that B-Myc inhibits the ability of c-Myc to transform cells and can inhibit cellular proliferation. Because B-myc is primarily expressed in hormonally regulated tissues with predominant expression in the epididymis, we examined in greater detail B-myc expression in the epididymis to ultimately understand potential roles B-myc may play in this and other hormonally regulated tissues. Herein we demonstrate that, in contrast to c-myc, B-myc mRNA and protein expression are highly regionalized with expression predominantly in the proximal caput epididymal region. Furthermore, in situ and immunohistochemical analyses show that within the epididymis B-myc mRNA and protein are specifically expressed by the epithelial cells and that B-Myc protein is localized to both the nuclear and cytosolic compartments. Castration and hormone replacement studies further show that expression of the B-myc mRNA is highly dependent on the presence of androgens and testicular factors. Finally, mRNA turnover studies demonstrate that the B-myc mRNA is relatively unstable with a half-life of 3.5 h. Taken together, the highly restricted and regulated expression of the B-myc gene suggests it may play important regulatory roles in the epididymis and perhaps other hormonally regulated tissues." @default.
- W2010201220 created "2016-06-24" @default.
- W2010201220 creator A5014552634 @default.
- W2010201220 creator A5015735297 @default.
- W2010201220 creator A5018000202 @default.
- W2010201220 creator A5033281579 @default.
- W2010201220 creator A5045525886 @default.
- W2010201220 date "2001-06-01" @default.
- W2010201220 modified "2023-10-18" @default.
- W2010201220 title "B-Myc, A Proximal Caput Epididymal Protein, Is Dependent on Androgens and Testicular Factors for Expression1" @default.
- W2010201220 cites W1953035097 @default.
- W2010201220 cites W1979341492 @default.
- W2010201220 cites W2007021266 @default.
- W2010201220 cites W2015441541 @default.
- W2010201220 cites W2051970761 @default.
- W2010201220 cites W2085856258 @default.
- W2010201220 cites W2086866261 @default.
- W2010201220 cites W2088741551 @default.
- W2010201220 cites W2098943333 @default.
- W2010201220 cites W2110888947 @default.
- W2010201220 cites W2128965225 @default.
- W2010201220 cites W2144503384 @default.
- W2010201220 cites W2169032405 @default.
- W2010201220 cites W2315713692 @default.
- W2010201220 cites W2328777842 @default.
- W2010201220 doi "https://doi.org/10.1095/biolreprod64.6.1600" @default.
- W2010201220 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11369584" @default.
- W2010201220 hasPublicationYear "2001" @default.
- W2010201220 type Work @default.
- W2010201220 sameAs 2010201220 @default.
- W2010201220 citedByCount "27" @default.
- W2010201220 countsByYear W20102012202012 @default.
- W2010201220 countsByYear W20102012202015 @default.
- W2010201220 countsByYear W20102012202016 @default.
- W2010201220 countsByYear W20102012202020 @default.
- W2010201220 countsByYear W20102012202021 @default.
- W2010201220 crossrefType "journal-article" @default.
- W2010201220 hasAuthorship W2010201220A5014552634 @default.
- W2010201220 hasAuthorship W2010201220A5015735297 @default.
- W2010201220 hasAuthorship W2010201220A5018000202 @default.
- W2010201220 hasAuthorship W2010201220A5033281579 @default.
- W2010201220 hasAuthorship W2010201220A5045525886 @default.
- W2010201220 hasBestOaLocation W20102012201 @default.
- W2010201220 hasConcept C104317684 @default.
- W2010201220 hasConcept C105580179 @default.
- W2010201220 hasConcept C150194340 @default.
- W2010201220 hasConcept C153911025 @default.
- W2010201220 hasConcept C165864922 @default.
- W2010201220 hasConcept C203014093 @default.
- W2010201220 hasConcept C204232928 @default.
- W2010201220 hasConcept C2781087480 @default.
- W2010201220 hasConcept C2781254305 @default.
- W2010201220 hasConcept C54355233 @default.
- W2010201220 hasConcept C555283112 @default.
- W2010201220 hasConcept C81439078 @default.
- W2010201220 hasConcept C86803240 @default.
- W2010201220 hasConcept C95444343 @default.
- W2010201220 hasConceptScore W2010201220C104317684 @default.
- W2010201220 hasConceptScore W2010201220C105580179 @default.
- W2010201220 hasConceptScore W2010201220C150194340 @default.
- W2010201220 hasConceptScore W2010201220C153911025 @default.
- W2010201220 hasConceptScore W2010201220C165864922 @default.
- W2010201220 hasConceptScore W2010201220C203014093 @default.
- W2010201220 hasConceptScore W2010201220C204232928 @default.
- W2010201220 hasConceptScore W2010201220C2781087480 @default.
- W2010201220 hasConceptScore W2010201220C2781254305 @default.
- W2010201220 hasConceptScore W2010201220C54355233 @default.
- W2010201220 hasConceptScore W2010201220C555283112 @default.
- W2010201220 hasConceptScore W2010201220C81439078 @default.
- W2010201220 hasConceptScore W2010201220C86803240 @default.
- W2010201220 hasConceptScore W2010201220C95444343 @default.
- W2010201220 hasIssue "6" @default.
- W2010201220 hasLocation W20102012201 @default.
- W2010201220 hasLocation W20102012202 @default.
- W2010201220 hasOpenAccess W2010201220 @default.
- W2010201220 hasPrimaryLocation W20102012201 @default.
- W2010201220 hasRelatedWork W1564102146 @default.
- W2010201220 hasRelatedWork W2009966535 @default.
- W2010201220 hasRelatedWork W2040216558 @default.
- W2010201220 hasRelatedWork W2088905849 @default.
- W2010201220 hasRelatedWork W2090547086 @default.
- W2010201220 hasRelatedWork W2131897044 @default.
- W2010201220 hasRelatedWork W2320912723 @default.
- W2010201220 hasRelatedWork W2359352629 @default.
- W2010201220 hasRelatedWork W2361002130 @default.
- W2010201220 hasRelatedWork W2392386717 @default.
- W2010201220 hasVolume "64" @default.
- W2010201220 isParatext "false" @default.
- W2010201220 isRetracted "false" @default.
- W2010201220 magId "2010201220" @default.
- W2010201220 workType "article" @default.