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• W2010201750 abstract "Differences in the gut microbiota have been reported between individuals with autism spectrum disorders (ASD) and neurotypical controls, although direct evidence that changes in the microbiome contribute to causing ASD has been scarce to date. Here we summarize some considerations of experimental design that can help untangle causality in this complex system. In particular, large cross-sectional studies that can factor out important variables such as diet, prospective longitudinal studies that remove some of the influence of interpersonal variation in the microbiome (which is generally high, especially in children), and studies transferring microbial communities into germ-free mice may be especially useful. Controlling for the effects of technical variables, which have complicated efforts to combine existing studies, is critical when biological effect sizes are small. Large citizen-science studies with thousands of participants such as the American Gut Project have been effective at uncovering subtle microbiome effects in self-collected samples and with self-reported diet and behavior data, and may provide a useful complement to other types of traditionally funded and conducted studies in the case of ASD, especially in the hypothesis generation phase." @default.
• W2010201750 created "2016-06-24" @default.
• W2010201750 creator A5004663363 @default.
• W2010201750 creator A5057060580 @default.
• W2010201750 creator A5066577130 @default.
• W2010201750 creator A5066906380 @default.
• W2010201750 creator A5086938254 @default.
• W2010201750 creator A5087710431 @default.
• W2010201750 date "2015-03-09" @default.
• W2010201750 modified "2023-10-14" @default.
• W2010201750 title "Towards large-cohort comparative studies to define the factors influencing the gut microbial community structure of ASD patients" @default.
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