FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010204002> ?p ?o ?g. }

• W2010204002 endingPage "e31950" @default.
• W2010204002 startingPage "e31950" @default.
• W2010204002 abstract "Long-chain polyunsaturated fatty acids (LC-PUFAs) such as arachidonic (ARA), eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids are essential components of biomembranes, particularly in neural tissues. Endogenous synthesis of ARA, EPA and DHA occurs from precursor dietary essential fatty acids such as linoleic and α-linolenic acid through elongation and Δ5 and Δ6 desaturations. With respect to desaturation activities some noteworthy differences have been noted in vertebrate classes. In mammals, the Δ5 activity is allocated to the Fads1 gene, while Fads2 is a Δ6 desaturase. In contrast, teleosts show distinct combinations of desaturase activities (e.g. bifunctional or separate Δ5 and Δ6 desaturases) apparently allocated to Fads2-type genes. To determine the timing of Fads1-Δ5 and Fads2-Δ6 evolution in vertebrates we used a combination of comparative and functional genomics with the analysis of key phylogenetic species. Our data show that Fads1 and Fads2 genes with Δ5 and Δ6 activities respectively, evolved before gnathostome radiation, since the catshark Scyliorhinus canicula has functional orthologues of both gene families. Consequently, the loss of Fads1 in teleosts is a secondary episode, while the existence of Δ5 activities in the same group most likely occurred through independent mutations into Fads2 type genes. Unexpectedly, we also establish that events of Fads1 gene expansion have taken place in birds and reptiles. Finally, a fourth Fads gene (Fads4) was found with an exclusive occurrence in mammalian genomes. Our findings enlighten the history of a crucially important gene family in vertebrate fatty acid metabolism and physiology and provide an explanation of how observed lineage-specific gene duplications, losses and diversifications might be linked to habitat-specific food web structures in different environments and over geological timescales." @default.
• W2010204002 created "2016-06-24" @default.
• W2010204002 creator A5027950362 @default.
• W2010204002 creator A5055137150 @default.
• W2010204002 creator A5056242605 @default.
• W2010204002 creator A5080287620 @default.
• W2010204002 creator A5084223106 @default.
• W2010204002 creator A5087372555 @default.
• W2010204002 date "2012-02-22" @default.
• W2010204002 modified "2023-10-08" @default.
• W2010204002 title "Functional Desaturase Fads1 (Δ5) and Fads2 (Δ6) Orthologues Evolved before the Origin of Jawed Vertebrates" @default.
• W2010204002 cites W125800115 @default.
• W2010204002 cites W1662088905 @default.
• W2010204002 cites W1966151581 @default.
• W2010204002 cites W1967497739 @default.
• W2010204002 cites W1967629384 @default.
• W2010204002 cites W1972549325 @default.
• W2010204002 cites W1974172717 @default.
• W2010204002 cites W1981713807 @default.
• W2010204002 cites W1983438527 @default.
• W2010204002 cites W1995813003 @default.
• W2010204002 cites W1998066116 @default.
• W2010204002 cites W2007711401 @default.
• W2010204002 cites W2011692785 @default.
• W2010204002 cites W2029598860 @default.
• W2010204002 cites W2049464845 @default.
• W2010204002 cites W2051745134 @default.
• W2010204002 cites W2055908840 @default.
• W2010204002 cites W2057081312 @default.
• W2010204002 cites W2062092298 @default.
• W2010204002 cites W2069536606 @default.
• W2010204002 cites W2070266571 @default.
• W2010204002 cites W2070961413 @default.
• W2010204002 cites W2071616533 @default.
• W2010204002 cites W2074765204 @default.
• W2010204002 cites W2078740418 @default.
• W2010204002 cites W2081175604 @default.
• W2010204002 cites W2081230107 @default.
• W2010204002 cites W2083617787 @default.
• W2010204002 cites W2086430840 @default.
• W2010204002 cites W2089928956 @default.
• W2010204002 cites W2097284850 @default.
• W2010204002 cites W2098448352 @default.
• W2010204002 cites W2111211467 @default.
• W2010204002 cites W2119362018 @default.
• W2010204002 cites W2127107334 @default.
• W2010204002 cites W2131871062 @default.
• W2010204002 cites W2144654387 @default.
• W2010204002 cites W2149790545 @default.
• W2010204002 cites W2158369256 @default.
• W2010204002 cites W2331207187 @default.
• W2010204002 doi "https://doi.org/10.1371/journal.pone.0031950" @default.
• W2010204002 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3285190" @default.
• W2010204002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22384110" @default.
• W2010204002 hasPublicationYear "2012" @default.
• W2010204002 type Work @default.
• W2010204002 sameAs 2010204002 @default.
• W2010204002 citedByCount "118" @default.
• W2010204002 countsByYear W20102040022012 @default.
• W2010204002 countsByYear W20102040022013 @default.
• W2010204002 countsByYear W20102040022014 @default.
• W2010204002 countsByYear W20102040022015 @default.
• W2010204002 countsByYear W20102040022016 @default.
• W2010204002 countsByYear W20102040022017 @default.
• W2010204002 countsByYear W20102040022018 @default.
• W2010204002 countsByYear W20102040022019 @default.
• W2010204002 countsByYear W20102040022020 @default.
• W2010204002 countsByYear W20102040022021 @default.
• W2010204002 countsByYear W20102040022022 @default.
• W2010204002 countsByYear W20102040022023 @default.
• W2010204002 crossrefType "journal-article" @default.
• W2010204002 hasAuthorship W2010204002A5027950362 @default.
• W2010204002 hasAuthorship W2010204002A5055137150 @default.
• W2010204002 hasAuthorship W2010204002A5056242605 @default.
• W2010204002 hasAuthorship W2010204002A5080287620 @default.
• W2010204002 hasAuthorship W2010204002A5084223106 @default.
• W2010204002 hasAuthorship W2010204002A5087372555 @default.
• W2010204002 hasBestOaLocation W20102040021 @default.
• W2010204002 hasConcept C104317684 @default.
• W2010204002 hasConcept C19038510 @default.
• W2010204002 hasConcept C2776091944 @default.
• W2010204002 hasConcept C2777129432 @default.
• W2010204002 hasConcept C2777171753 @default.
• W2010204002 hasConcept C2778915593 @default.
• W2010204002 hasConcept C2778961482 @default.
• W2010204002 hasConcept C543025807 @default.
• W2010204002 hasConcept C54355233 @default.
• W2010204002 hasConcept C55493867 @default.
• W2010204002 hasConcept C86803240 @default.
• W2010204002 hasConceptScore W2010204002C104317684 @default.
• W2010204002 hasConceptScore W2010204002C19038510 @default.
• W2010204002 hasConceptScore W2010204002C2776091944 @default.
• W2010204002 hasConceptScore W2010204002C2777129432 @default.
• W2010204002 hasConceptScore W2010204002C2777171753 @default.
• W2010204002 hasConceptScore W2010204002C2778915593 @default.
• W2010204002 hasConceptScore W2010204002C2778961482 @default.
• W2010204002 hasConceptScore W2010204002C543025807 @default.
• W2010204002 hasConceptScore W2010204002C54355233 @default.

• next