Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010210717> ?p ?o ?g. }
- W2010210717 endingPage "307" @default.
- W2010210717 startingPage "299" @default.
- W2010210717 abstract "Activation of excitatory amino acid (EAA) receptors can induce neurodegeneration by two major mechanisms of excitotoxicity, one related to the influx of Na(+), Cl(-) and water, and the other to the increase in intracellular calcium concentration ([Ca(2+)](i)). Thus, acute microinjection of EAAs in several areas of the central nervous system (CNS) has been used to produce neurodegenerative models. We studied the excitotoxic pattern associated with acute microinjection of AMPA in rat hippocampus, medial septum-diagonal band of Broca (MS-DBB), prefrontal cortex and retina. In all cases progressive neuronal loss, glial reaction and development of intra- and extracellular calcium concretions were observed. However, a CNS-area differential vulnerability was revealed, as shown by the specific atrophy of MS-DBB and its limited calcification. Whether calcium deposits are a defensive mechanism against the massive increment of free cytoplasmatic calcium is discussed on the basis of ultrastructural data and previous results." @default.
- W2010210717 created "2016-06-24" @default.
- W2010210717 creator A5031239152 @default.
- W2010210717 creator A5033642848 @default.
- W2010210717 creator A5045840439 @default.
- W2010210717 creator A5062766708 @default.
- W2010210717 creator A5075771817 @default.
- W2010210717 date "2000-03-09" @default.
- W2010210717 modified "2023-10-06" @default.
- W2010210717 title "Excitatory amino acids and neurodegeneration: a hypothetical role of calcium precipitation" @default.
- W2010210717 cites W1564601025 @default.
- W2010210717 cites W1897205131 @default.
- W2010210717 cites W1963852341 @default.
- W2010210717 cites W1966014062 @default.
- W2010210717 cites W1966634044 @default.
- W2010210717 cites W1968923413 @default.
- W2010210717 cites W1970986406 @default.
- W2010210717 cites W1976289522 @default.
- W2010210717 cites W1977134349 @default.
- W2010210717 cites W1979406476 @default.
- W2010210717 cites W1986719092 @default.
- W2010210717 cites W1991658908 @default.
- W2010210717 cites W2009822720 @default.
- W2010210717 cites W2011262365 @default.
- W2010210717 cites W2024945446 @default.
- W2010210717 cites W2032665701 @default.
- W2010210717 cites W2037001268 @default.
- W2010210717 cites W2046196975 @default.
- W2010210717 cites W2053268711 @default.
- W2010210717 cites W2053828674 @default.
- W2010210717 cites W2054660729 @default.
- W2010210717 cites W2054683291 @default.
- W2010210717 cites W2054829715 @default.
- W2010210717 cites W2058533626 @default.
- W2010210717 cites W2065662813 @default.
- W2010210717 cites W2070008559 @default.
- W2010210717 cites W2077033698 @default.
- W2010210717 cites W2077065264 @default.
- W2010210717 cites W2082103608 @default.
- W2010210717 cites W2096508436 @default.
- W2010210717 cites W2101535275 @default.
- W2010210717 cites W2111636333 @default.
- W2010210717 cites W2147457356 @default.
- W2010210717 cites W2171584675 @default.
- W2010210717 cites W2246678623 @default.
- W2010210717 cites W2314455263 @default.
- W2010210717 cites W2398392813 @default.
- W2010210717 cites W274428266 @default.
- W2010210717 doi "https://doi.org/10.1016/s0736-5748(99)00098-2" @default.
- W2010210717 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10715584" @default.
- W2010210717 hasPublicationYear "2000" @default.
- W2010210717 type Work @default.
- W2010210717 sameAs 2010210717 @default.
- W2010210717 citedByCount "44" @default.
- W2010210717 countsByYear W20102107172012 @default.
- W2010210717 countsByYear W20102107172013 @default.
- W2010210717 countsByYear W20102107172014 @default.
- W2010210717 countsByYear W20102107172015 @default.
- W2010210717 countsByYear W20102107172016 @default.
- W2010210717 countsByYear W20102107172017 @default.
- W2010210717 countsByYear W20102107172021 @default.
- W2010210717 countsByYear W20102107172022 @default.
- W2010210717 crossrefType "journal-article" @default.
- W2010210717 hasAuthorship W2010210717A5031239152 @default.
- W2010210717 hasAuthorship W2010210717A5033642848 @default.
- W2010210717 hasAuthorship W2010210717A5045840439 @default.
- W2010210717 hasAuthorship W2010210717A5062766708 @default.
- W2010210717 hasAuthorship W2010210717A5075771817 @default.
- W2010210717 hasConcept C112592302 @default.
- W2010210717 hasConcept C126322002 @default.
- W2010210717 hasConcept C160268369 @default.
- W2010210717 hasConcept C169760540 @default.
- W2010210717 hasConcept C170493617 @default.
- W2010210717 hasConcept C17077164 @default.
- W2010210717 hasConcept C178790620 @default.
- W2010210717 hasConcept C181080969 @default.
- W2010210717 hasConcept C185592680 @default.
- W2010210717 hasConcept C2776108384 @default.
- W2010210717 hasConcept C2776925932 @default.
- W2010210717 hasConcept C2779134260 @default.
- W2010210717 hasConcept C2780648746 @default.
- W2010210717 hasConcept C2781012912 @default.
- W2010210717 hasConcept C2781161787 @default.
- W2010210717 hasConcept C519063684 @default.
- W2010210717 hasConcept C55493867 @default.
- W2010210717 hasConcept C61174792 @default.
- W2010210717 hasConcept C62525196 @default.
- W2010210717 hasConcept C67018056 @default.
- W2010210717 hasConcept C71924100 @default.
- W2010210717 hasConcept C86803240 @default.
- W2010210717 hasConcept C95444343 @default.
- W2010210717 hasConceptScore W2010210717C112592302 @default.
- W2010210717 hasConceptScore W2010210717C126322002 @default.
- W2010210717 hasConceptScore W2010210717C160268369 @default.
- W2010210717 hasConceptScore W2010210717C169760540 @default.
- W2010210717 hasConceptScore W2010210717C170493617 @default.
- W2010210717 hasConceptScore W2010210717C17077164 @default.
- W2010210717 hasConceptScore W2010210717C178790620 @default.