FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010214706> ?p ?o ?g. }

• W2010214706 endingPage "198" @default.
• W2010214706 startingPage "191" @default.
• W2010214706 abstract "Cadmium (Cd) is a widespread environmental contaminant. Cd affects the cellular homeostasis and generates damage via complex mechanisms involving interactions with other metals, induction of oxidative stress and apoptotic or necrotic cell death, depending on the cell type and the concentration. The goal of the present study was to investigate the effect of exposure to CdCl(2) on the intracellular trace elements levels, the antioxidant enzyme activities and on DNA damage in the Jurkat T cell line. Cells were exposed to 5, 25 and 50 μM of CdCl(2) for 24 h. Cd significantly reduced the viability of Jurkat T cells and induced a dose-dependent increase in DNA damage with statistically significant differences relative to controls (p<0.001); the superoxide dismutase and glutathione peroxidase activities were significantly decreased. Lipid peroxidation and protein carbonyl levels were significantly increased while glutathione and the total intracellular sulfhydryl groups were decreased showing clearly that an oxidative stress was generated by Cd. Surprisingly the treatment with Cd induced a significant increase in the intracellular levels of all the trace elements measured. The results indicate that cellular pro-oxidative stress induced by Cd is most likely mediated by disruption of redox homeostasis associated to a mishandling of redox-active transition metals and causes lipid and protein oxidation and oxidative DNA damage in Jurkat T cells." @default.
• W2010214706 created "2016-06-24" @default.
• W2010214706 creator A5053170164 @default.
• W2010214706 creator A5063664081 @default.
• W2010214706 creator A5068549684 @default.
• W2010214706 creator A5074149204 @default.
• W2010214706 date "2011-02-01" @default.
• W2010214706 modified "2023-10-01" @default.
• W2010214706 title "Cadmium chloride-induced oxidative stress and DNA damage in the human Jurkat T cell line is not linked to intracellular trace elements depletion" @default.
• W2010214706 cites W1498636565 @default.
• W2010214706 cites W1546592314 @default.
• W2010214706 cites W1567614586 @default.
• W2010214706 cites W1768247331 @default.
• W2010214706 cites W1970568250 @default.
• W2010214706 cites W1971200376 @default.
• W2010214706 cites W1972046435 @default.
• W2010214706 cites W1972271647 @default.
• W2010214706 cites W1977446960 @default.
• W2010214706 cites W1981312416 @default.
• W2010214706 cites W1982870743 @default.
• W2010214706 cites W1983461753 @default.
• W2010214706 cites W1984872094 @default.
• W2010214706 cites W1990790739 @default.
• W2010214706 cites W1991535520 @default.
• W2010214706 cites W1993369608 @default.
• W2010214706 cites W1995966908 @default.
• W2010214706 cites W1998019063 @default.
• W2010214706 cites W2001367811 @default.
• W2010214706 cites W2002821159 @default.
• W2010214706 cites W2006342727 @default.
• W2010214706 cites W2024170505 @default.
• W2010214706 cites W2027756656 @default.
• W2010214706 cites W2028482993 @default.
• W2010214706 cites W2033968745 @default.
• W2010214706 cites W2034574233 @default.
• W2010214706 cites W2035594105 @default.
• W2010214706 cites W2036366834 @default.
• W2010214706 cites W2039306991 @default.
• W2010214706 cites W2039787604 @default.
• W2010214706 cites W2040765343 @default.
• W2010214706 cites W2045034340 @default.
• W2010214706 cites W2047943139 @default.
• W2010214706 cites W2052433291 @default.
• W2010214706 cites W2057945409 @default.
• W2010214706 cites W2061508611 @default.
• W2010214706 cites W2063728947 @default.
• W2010214706 cites W2065847176 @default.
• W2010214706 cites W2067351147 @default.
• W2010214706 cites W2068951579 @default.
• W2010214706 cites W2072508481 @default.
• W2010214706 cites W2073841855 @default.
• W2010214706 cites W2074010373 @default.
• W2010214706 cites W2074356401 @default.
• W2010214706 cites W2080817987 @default.
• W2010214706 cites W2085300901 @default.
• W2010214706 cites W2088866343 @default.
• W2010214706 cites W2093684823 @default.
• W2010214706 cites W2094864349 @default.
• W2010214706 cites W2119775467 @default.
• W2010214706 cites W2127895812 @default.
• W2010214706 cites W2130122826 @default.
• W2010214706 cites W2130385250 @default.
• W2010214706 cites W2137996875 @default.
• W2010214706 cites W2146684483 @default.
• W2010214706 cites W2197332903 @default.
• W2010214706 doi "https://doi.org/10.1016/j.tiv.2010.10.018" @default.
• W2010214706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21040778" @default.
• W2010214706 hasPublicationYear "2011" @default.
• W2010214706 type Work @default.
• W2010214706 sameAs 2010214706 @default.
• W2010214706 citedByCount "66" @default.
• W2010214706 countsByYear W20102147062012 @default.
• W2010214706 countsByYear W20102147062013 @default.
• W2010214706 countsByYear W20102147062014 @default.
• W2010214706 countsByYear W20102147062015 @default.
• W2010214706 countsByYear W20102147062016 @default.
• W2010214706 countsByYear W20102147062017 @default.
• W2010214706 countsByYear W20102147062018 @default.
• W2010214706 countsByYear W20102147062019 @default.
• W2010214706 countsByYear W20102147062020 @default.
• W2010214706 countsByYear W20102147062021 @default.
• W2010214706 countsByYear W20102147062022 @default.
• W2010214706 countsByYear W20102147062023 @default.
• W2010214706 crossrefType "journal-article" @default.
• W2010214706 hasAuthorship W2010214706A5053170164 @default.
• W2010214706 hasAuthorship W2010214706A5063664081 @default.
• W2010214706 hasAuthorship W2010214706A5068549684 @default.
• W2010214706 hasAuthorship W2010214706A5074149204 @default.
• W2010214706 hasConcept C143425029 @default.
• W2010214706 hasConcept C153911025 @default.
• W2010214706 hasConcept C178790620 @default.
• W2010214706 hasConcept C179464577 @default.
• W2010214706 hasConcept C181199279 @default.
• W2010214706 hasConcept C185592680 @default.
• W2010214706 hasConcept C203014093 @default.
• W2010214706 hasConcept C2775838275 @default.
• W2010214706 hasConcept C2776090121 @default.
• W2010214706 hasConcept C2776151105 @default.

• next