FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010217177> ?p ?o ?g. }

• W2010217177 endingPage "489" @default.
• W2010217177 startingPage "479" @default.
• W2010217177 abstract "Previous rodent studies have demonstrated the capacity of cerebellar transplants to organize into trilaminar cell layers typically observed in the normal cerebellum. In Purkinje Cell (PC)-deficient animals, PCs will migrate into the host and form synaptic connections. Recently, fetal cerebellar grafts transplanted into the Purkinje cell degeneration (pcd) mutant mouse were shown to result in an improvement of motor behaviors. These studies indicate the potential therapeutic use of neural transplantation in patients with cerebellar degeneration. In the present study, human fetal cerebellar tissue (8.5 wk postconception) was dissociated and transplanted into the normal cerebellum of nude mice. Six months following transplantation, histological analysis revealed donor cells in recipient mice. Immunostaining for the 28 kDa calcium-binding protein (calbindin) revealed the presence of donor PCs that were organized in discrete cellular layers within the transplant neuropil. In most cases the dendritic processes were oriented in a planar fashion perpendicular to the transplant cell layer. Human neurofilament immunostaining revealed bundles of donor fibers within the core of the transplant and/or at the periphery. These bundles were found to be calbindin positive (PC fibers). Three animals provided evidence of donor PC axon growth ventrally into host white matter, and in one case, this ventral migration reached the deep cerebellar nuclei. Most notable was the development of a pronounced folia-like organization by the implanted cell suspensions. Glial processes within the grafts were aligned perpendicular to the long axis of the transplant folia. These results demonstrate the capacity of human fetal cerebellar cell suspension to reorganize into cell layers typical of the normal cerebellum following transplantation into the rodent cerebellum, and develop an organotypic folia-like organization." @default.
• W2010217177 created "2016-06-24" @default.
• W2010217177 creator A5066771029 @default.
• W2010217177 date "1997-09-01" @default.
• W2010217177 modified "2023-10-18" @default.
• W2010217177 title "Organization and histochemical phenotype of human fetal cerebellar cells following transplantation into the cerebellum of nude mice" @default.
• W2010217177 cites W13893899 @default.
• W2010217177 cites W1487147159 @default.
• W2010217177 cites W1519107183 @default.
• W2010217177 cites W1965607470 @default.
• W2010217177 cites W1967436035 @default.
• W2010217177 cites W1968353095 @default.
• W2010217177 cites W1971764977 @default.
• W2010217177 cites W1974528931 @default.
• W2010217177 cites W1974559976 @default.
• W2010217177 cites W1976911841 @default.
• W2010217177 cites W1981132843 @default.
• W2010217177 cites W1991794728 @default.
• W2010217177 cites W1995964050 @default.
• W2010217177 cites W1996247222 @default.
• W2010217177 cites W2000302801 @default.
• W2010217177 cites W2003226751 @default.
• W2010217177 cites W2003708260 @default.
• W2010217177 cites W2004619199 @default.
• W2010217177 cites W2015856949 @default.
• W2010217177 cites W2017689311 @default.
• W2010217177 cites W2028518963 @default.
• W2010217177 cites W2030062966 @default.
• W2010217177 cites W2034191611 @default.
• W2010217177 cites W2034743776 @default.
• W2010217177 cites W2040196647 @default.
• W2010217177 cites W2047755130 @default.
• W2010217177 cites W2052086914 @default.
• W2010217177 cites W2054364273 @default.
• W2010217177 cites W2057121260 @default.
• W2010217177 cites W2057756015 @default.
• W2010217177 cites W2067622798 @default.
• W2010217177 cites W2071080651 @default.
• W2010217177 cites W2073618869 @default.
• W2010217177 cites W2075199998 @default.
• W2010217177 cites W2087690085 @default.
• W2010217177 cites W2093839169 @default.
• W2010217177 cites W2104429436 @default.
• W2010217177 cites W2105349736 @default.
• W2010217177 cites W2118330183 @default.
• W2010217177 cites W2227608832 @default.
• W2010217177 cites W2291663432 @default.
• W2010217177 cites W2399955537 @default.
• W2010217177 cites W2460838793 @default.
• W2010217177 cites W358726194 @default.
• W2010217177 cites W563232987 @default.
• W2010217177 doi "https://doi.org/10.1016/s0963-6897(97)00048-1" @default.
• W2010217177 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9331499" @default.
• W2010217177 hasPublicationYear "1997" @default.
• W2010217177 type Work @default.
• W2010217177 sameAs 2010217177 @default.
• W2010217177 citedByCount "4" @default.
• W2010217177 crossrefType "journal-article" @default.
• W2010217177 hasAuthorship W2010217177A5066771029 @default.
• W2010217177 hasConcept C104317684 @default.
• W2010217177 hasConcept C126322002 @default.
• W2010217177 hasConcept C127716648 @default.
• W2010217177 hasConcept C142724271 @default.
• W2010217177 hasConcept C169760540 @default.
• W2010217177 hasConcept C172680121 @default.
• W2010217177 hasConcept C2779234561 @default.
• W2010217177 hasConcept C2779652256 @default.
• W2010217177 hasConcept C2908667503 @default.
• W2010217177 hasConcept C2911091166 @default.
• W2010217177 hasConcept C54355233 @default.
• W2010217177 hasConcept C71924100 @default.
• W2010217177 hasConcept C86803240 @default.
• W2010217177 hasConceptScore W2010217177C104317684 @default.
• W2010217177 hasConceptScore W2010217177C126322002 @default.
• W2010217177 hasConceptScore W2010217177C127716648 @default.
• W2010217177 hasConceptScore W2010217177C142724271 @default.
• W2010217177 hasConceptScore W2010217177C169760540 @default.
• W2010217177 hasConceptScore W2010217177C172680121 @default.
• W2010217177 hasConceptScore W2010217177C2779234561 @default.
• W2010217177 hasConceptScore W2010217177C2779652256 @default.
• W2010217177 hasConceptScore W2010217177C2908667503 @default.
• W2010217177 hasConceptScore W2010217177C2911091166 @default.
• W2010217177 hasConceptScore W2010217177C54355233 @default.
• W2010217177 hasConceptScore W2010217177C71924100 @default.
• W2010217177 hasConceptScore W2010217177C86803240 @default.
• W2010217177 hasIssue "5" @default.
• W2010217177 hasLocation W20102171771 @default.
• W2010217177 hasOpenAccess W2010217177 @default.
• W2010217177 hasPrimaryLocation W20102171771 @default.
• W2010217177 hasRelatedWork W1930056436 @default.
• W2010217177 hasRelatedWork W1971548818 @default.
• W2010217177 hasRelatedWork W2026940730 @default.
• W2010217177 hasRelatedWork W2054592168 @default.
• W2010217177 hasRelatedWork W2278952946 @default.
• W2010217177 hasRelatedWork W2376074409 @default.
• W2010217177 hasRelatedWork W2419210127 @default.
• W2010217177 hasRelatedWork W2795290394 @default.
• W2010217177 hasRelatedWork W42647268 @default.

• next